AR054219A1 - FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS - Google Patents

FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS

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Publication number
AR054219A1
AR054219A1 ARP060100302A AR054219A1 AR 054219 A1 AR054219 A1 AR 054219A1 AR P060100302 A ARP060100302 A AR P060100302A AR 054219 A1 AR054219 A1 AR 054219A1
Authority
AR
Argentina
Prior art keywords
aztreonam lysinate
treatment
aztreonam
infections caused
gram
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Alan Bruce Montgomery
Manfred Kelller
Frank-Christophe Lintz
Original Assignee
Corus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corus Pharma Inc filed Critical Corus Pharma Inc
Priority to ARP060100302 priority Critical patent/AR054219A1/en
Publication of AR054219A1 publication Critical patent/AR054219A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un método y una composicion para el tratamiento de infecciones pulmonares bacteriales causadas por la bacteria gram-negativa para el tratamiento de infecciones causadas por Escherichia coli, Klebsiella Pneumoniae, K. Oxytoca, Haaemophilus influenzae, Proteus Mirabilis, Pseudomonas aeruginosa, Enterobacter Species, Serratia marcescens, así como también todas aquellas causadas por Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans y Pseudomonas aeruginosas resistentes a multi-drogas, utilizando una formulacion concentrada de lisinato de aztreonam liberada como un aerosol o como un polvo seco inhalable. Un proceso para la fabricacion de lisinato de aztreonam. Reivindicacion 1: Un método para el tratamiento de infecciones pulmonares causadas por bacterias gramnegativas, dicho método comprendiendo los siguientes pasos: a) preparar una formulacion de lisinato de aztreonam inhalable concentrado que comprende alrededor de 1 a 250mg de lisinato de aztreonam, dicho lisinato de aztreonam en forma de polvo seco inhalable, o de aproximadamente 1 a aproximadamente 250 mg de lisinato de aztreonam o una sal farmacéuticamente aceptable del mismo, disuelta en aproximadamente 1 a aproximadamente 5 ml de una solucion en aerosol que contiene aproximadamente 0,1 a aproximadamente 0,9 % de cloruro o un equivalente del mismo; y b) liberar dicho polvo seco o la solucion en aerosol del lisinato de aztreonam al espacio endobronquial de las vías respiratorias de los pulmones de un paciente que lo necesita mediante una nebulizacion en aerosol que tiene diámetro promedio medio masivo de entre aproximadamente 1 y aproximadamente 5 micrones. Reivindicacion 11: Una composicion farmacéuticamente aceptable inhalable que comprende aproximadamente 1 a 250 mg de lisinato de aztreonam por una dosis, dicha composicion adecuada para el tratamiento de infecciones bacterianas pulmonares causadas por bacteria gramnegativa en donde dicho lisinato de aztreonam comprende cantidades equimolares de aztreonam y lisinato preparado como un polvo seco inhalable. Reivindicacion 34: Un lisinato de alfa-aztreonam purificado para el tratamiento de infecciones pulmonares causados por bacterias gramnegativas.A method and composition for the treatment of bacterial lung infections caused by gram-negative bacteria for the treatment of infections caused by Escherichia coli, Klebsiella Pneumoniae, K. Oxytoca, Haaemophilus influenzae, Proteus Mirabilis, Pseudomonas aeruginosa, Enterobacter Species, Serratia marcescens , as well as all those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans and Pseudomonas aeruginosas multi-drug resistant, using a concentrated formulation of aztreonam lysinate released as an aerosol or as an inhaled dry powder. A process for the manufacture of aztreonam lysinate. Claim 1: A method for the treatment of lung infections caused by gram-negative bacteria, said method comprising the following steps: a) preparing a formulation of concentrated inhalable aztreonam lysinate, comprising about 1 to 250 mg of aztreonam lysinate, said aztreonam lysinate in the form of an inhalable dry powder, or about 1 to about 250 mg of aztreonam lysinate or a pharmaceutically acceptable salt thereof, dissolved in about 1 to about 5 ml of an aerosol solution containing about 0.1 to about 0, 9% chloride or an equivalent thereof; and b) releasing said dry powder or the aerosol solution of aztreonam lysinate to the endobronchial space of the airways of the lungs of a patient in need by means of an aerosol spray that has a mean mass average diameter between about 1 and about 5 microns. . Claim 11: An inhalable pharmaceutically acceptable composition comprising approximately 1 to 250 mg of aztreonam lysinate for one dose, said composition suitable for the treatment of pulmonary bacterial infections caused by gram-negative bacteria wherein said aztreonam lysinate includes equimolar amounts of aztreonam and lisinate prepared as an inhalable dry powder. Claim 34: A purified alpha-aztreonam lisinate for the treatment of lung infections caused by gram-negative bacteria.

ARP060100302 2006-01-27 2006-01-27 FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS AR054219A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP060100302 AR054219A1 (en) 2006-01-27 2006-01-27 FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP060100302 AR054219A1 (en) 2006-01-27 2006-01-27 FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS

Publications (1)

Publication Number Publication Date
AR054219A1 true AR054219A1 (en) 2007-06-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100302 AR054219A1 (en) 2006-01-27 2006-01-27 FORMULATION OF INHALABLE AZTREONAM LISINATE FOR THE TREATMENT AND PREVENTION OF BACTERIAL PULMONARY INFECTIONS

Country Status (1)

Country Link
AR (1) AR054219A1 (en)

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