AR053578A1 - DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX - Google Patents
DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEXInfo
- Publication number
- AR053578A1 AR053578A1 ARP060101465A ARP060101465A AR053578A1 AR 053578 A1 AR053578 A1 AR 053578A1 AR P060101465 A ARP060101465 A AR P060101465A AR P060101465 A ARP060101465 A AR P060101465A AR 053578 A1 AR053578 A1 AR 053578A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- modulation
- receptor complex
- gabaa receptor
- rön
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la presente son utiles en el tratamiento de enfermedades y trastornos del sistema nervioso central, los cuales responden a la modulacion del complejo receptor GABAA, y en articular para combatir la ansiedad y enfermedades relacionadas. Reivindicacion 1: Un compuesto de la formula general (1), o un N-oxido del mismo, o cualquiera de sus isomeros o cualquier mezcla de sus isomeros, o una sal farmacéuticamente aceptable de los mismos, en donde Ra, Rb y Rc independientes entre sí representan H, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo, alquinilo, hidroxi, alcoxi, alcoxialquilo, arilalquilo, formilo, alquilcarbonilo o alcoxialquilcarbonilo; Rd representa un grupo heteroarilo; cuyo grupo heteroarilo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados a partir del grupo consistente en: halo, hidroxi, R'RöN-, R'RöN-alquilo, ciano, nitro, trifluormetilo, trifluormetoxi, hidrazino, alcoxi, cicloalcoxi, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo y alquinilo, en donde R' y Rö independientes entre sí son H o alquilo.The compounds herein are useful in the treatment of diseases and disorders of the central nervous system, which respond to the modulation of the GABAA receptor complex, and in articulation to combat anxiety and related diseases. Claim 1: A compound of the general formula (1), or an N-oxide thereof, or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof, wherein independent Ra, Rb and Rc they represent H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, alkoxyalkyl, arylalkyl, formyl, alkylcarbonyl or alkoxyalkylcarbonyl; Rd represents a heteroaryl group; whose heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, hydroxy, R'RöN-, R'RöN-alkyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, hydrazino, alkoxy, cycloalkoxy, alkyl , cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl, wherein R 'and Rö independent of each other are H or alkyl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200500530 | 2005-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053578A1 true AR053578A1 (en) | 2007-05-09 |
Family
ID=38048147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101465A AR053578A1 (en) | 2005-04-13 | 2006-04-12 | DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN101141958A (en) |
AR (1) | AR053578A1 (en) |
BR (1) | BRPI0609417A2 (en) |
TW (1) | TW200716602A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107445845A (en) * | 2017-08-24 | 2017-12-08 | 重庆沃肯精细化工有限公司 | The method of one kind synthesis Clofazimine key intermediate N (4 chlorphenyl) 1,2 phenylenediamine |
-
2006
- 2006-04-07 BR BRPI0609417-1A patent/BRPI0609417A2/en not_active IP Right Cessation
- 2006-04-07 CN CNA2006800082378A patent/CN101141958A/en active Pending
- 2006-04-10 TW TW095112595A patent/TW200716602A/en unknown
- 2006-04-12 AR ARP060101465A patent/AR053578A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101141958A (en) | 2008-03-12 |
TW200716602A (en) | 2007-05-01 |
BRPI0609417A2 (en) | 2011-10-18 |
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