AR053578A1 - DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX - Google Patents

DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX

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Publication number
AR053578A1
AR053578A1 ARP060101465A ARP060101465A AR053578A1 AR 053578 A1 AR053578 A1 AR 053578A1 AR P060101465 A ARP060101465 A AR P060101465A AR P060101465 A ARP060101465 A AR P060101465A AR 053578 A1 AR053578 A1 AR 053578A1
Authority
AR
Argentina
Prior art keywords
alkyl
modulation
receptor complex
gabaa receptor
rön
Prior art date
Application number
ARP060101465A
Other languages
Spanish (es)
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of AR053578A1 publication Critical patent/AR053578A1/en

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Abstract

Los compuestos de la presente son utiles en el tratamiento de enfermedades y trastornos del sistema nervioso central, los cuales responden a la modulacion del complejo receptor GABAA, y en articular para combatir la ansiedad y enfermedades relacionadas. Reivindicacion 1: Un compuesto de la formula general (1), o un N-oxido del mismo, o cualquiera de sus isomeros o cualquier mezcla de sus isomeros, o una sal farmacéuticamente aceptable de los mismos, en donde Ra, Rb y Rc independientes entre sí representan H, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo, alquinilo, hidroxi, alcoxi, alcoxialquilo, arilalquilo, formilo, alquilcarbonilo o alcoxialquilcarbonilo; Rd representa un grupo heteroarilo; cuyo grupo heteroarilo está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados a partir del grupo consistente en: halo, hidroxi, R'RöN-, R'RöN-alquilo, ciano, nitro, trifluormetilo, trifluormetoxi, hidrazino, alcoxi, cicloalcoxi, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo y alquinilo, en donde R' y Rö independientes entre sí son H o alquilo.The compounds herein are useful in the treatment of diseases and disorders of the central nervous system, which respond to the modulation of the GABAA receptor complex, and in articulation to combat anxiety and related diseases. Claim 1: A compound of the general formula (1), or an N-oxide thereof, or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof, wherein independent Ra, Rb and Rc they represent H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, alkoxyalkyl, arylalkyl, formyl, alkylcarbonyl or alkoxyalkylcarbonyl; Rd represents a heteroaryl group; whose heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, hydroxy, R'RöN-, R'RöN-alkyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, hydrazino, alkoxy, cycloalkoxy, alkyl , cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl, wherein R 'and Rö independent of each other are H or alkyl.

ARP060101465A 2005-04-13 2006-04-12 DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX AR053578A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200500530 2005-04-13

Publications (1)

Publication Number Publication Date
AR053578A1 true AR053578A1 (en) 2007-05-09

Family

ID=38048147

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060101465A AR053578A1 (en) 2005-04-13 2006-04-12 DERIVATIVES OF BENZIMIDAZOL AND ITS USE FOR THE MODULATION OF THE GABAA RECEPTOR COMPLEX

Country Status (4)

Country Link
CN (1) CN101141958A (en)
AR (1) AR053578A1 (en)
BR (1) BRPI0609417A2 (en)
TW (1) TW200716602A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107445845A (en) * 2017-08-24 2017-12-08 重庆沃肯精细化工有限公司 The method of one kind synthesis Clofazimine key intermediate N (4 chlorphenyl) 1,2 phenylenediamine

Also Published As

Publication number Publication date
TW200716602A (en) 2007-05-01
BRPI0609417A2 (en) 2011-10-18
CN101141958A (en) 2008-03-12

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