AR052818A1 - DERIVATIVES OF 6- (1H-PIRAZOL-5-IL) -1,3,5-TRIAZINE, PROCEDURES FOR THE PREPARATION AND USE AS PROTECTIVE AGENTS AGAINST UV RADIATION - Google Patents
DERIVATIVES OF 6- (1H-PIRAZOL-5-IL) -1,3,5-TRIAZINE, PROCEDURES FOR THE PREPARATION AND USE AS PROTECTIVE AGENTS AGAINST UV RADIATIONInfo
- Publication number
- AR052818A1 AR052818A1 ARP050105267A ARP050105267A AR052818A1 AR 052818 A1 AR052818 A1 AR 052818A1 AR P050105267 A ARP050105267 A AR P050105267A AR P050105267 A ARP050105267 A AR P050105267A AR 052818 A1 AR052818 A1 AR 052818A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- optionally substituted
- alkyl
- group
- branched
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 239000003223 protective agent Substances 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
- -1 C3-7 cycloalkyl radical Chemical class 0.000 abstract 14
- 150000003254 radicals Chemical class 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 150000003918 triazines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Reivindicacion 1: Derivado de triazina de formula general (1), en donde: R1 representa un átomo de hidrogeno; un radical cicloalquilo C3-7 opcionalmente sustituido; un radical arilo opcionalmente sustituido con un grupo que se selecciona de entre arilo, halogeno, un grupo alcoxi C1-6 y un grupo alquilo C1-6; un radical arilalquilo en el cual el grupo alquilo es una cadena C1-6 opcionalmente sustituido; un radical alquilo lineal o ramificado, C1-18 opcionalmente sustituido con un grupo seleccionado de entre -SO3M, -N(R4)3+ y un grupo de formula (2), en el que: n = 0 o 1; m = 0, 1, 2, 3, o 4; R5, R6, R7, R8 y R9 son iguales o diferentes entre sí y se seleccionan de entre un radical alquilo C1-6 opcionalmente sustituido, un radical alcoxi C1-6, un radical arilo opcionalmente sustituido y un radical -OSi(R10)3; R10 representa un radical alquilo C1-6, un radical alcoxi C1-6 o un radical arilo opcionalmente sustituido; M es H, Na o K; R4 es un grupo alquilo opcionalmente sustituido; R2 y R3 son iguales o diferentes entre sí y se seleccionan de entre hidrogeno; radical alquilo opcionalmente sustituido, lineal o ramificado, C1-4; y radical arilo opcionalmente sustituido; o bien R2 y R3 están condensados con un sistema anular mono- o policíclico opcionalmente heterosustituido; A1 es un radical de formula general (3) o (4); A2 es un radical de formula general (3), (5) o (6); R11 representa un átomo de hidrogeno; un radical alquilo opcionalmente sustituido, lineal o ramificado, saturado o insaturado, C1-6; un radical -OH; R12 representa un átomo de hidrogeno; un radical hidroxilo; un radical -COOR15; un radical -CONR16R17; un radical alcoxi C1-18 opcionalmente sustituido; un radical fenoxi; un radical cicloalquilo C3-7; un radical fenilo o naftilo; un radical fenilo o naftilo que lleve 1 o 2 sustituyentes idénticos o diferentes, tales como fenilo, cloro, alcoxi C1-6, alquilo conteniendo C1-6; un radical alquilo, lineal o ramificado, saturado o insaturado, C1-18, opcionalmente sustituido con al menos un radical -OH, fenilo u opcionalmente sustituido por un grupo de formula general (2), segun se ha definido más arriba; R15, R16 y R17 son iguales o diferentes entre sí y se seleccionan de entre hidrogeno, un radical alquilo, lineal o ramificado C1-18 opcionalmente sustituido; R14 es H o -SO3M, siendo M segun se define más arriba; R13 y R13' pueden ser iguales o diferentes entre sí y se seleccionan de entre hidrogeno; radical acilo opcionalmente sustituido C1-18; radical alquilo, lineal o ramificado, saturado o insaturado, C1-18, opcionalmente sustituido con al menos un radical -OH, un grupo -SO3M, un grupo -N(R4)3+, siendo M y R4 segun se definen más arriba o por un grupo de formula general (2), segun se define más arriba.Claim 1: Triazine derivative of general formula (1), wherein: R 1 represents a hydrogen atom; an optionally substituted C3-7 cycloalkyl radical; an aryl radical optionally substituted with a group selected from aryl, halogen, a C1-6 alkoxy group and a C1-6 alkyl group; an arylalkyl radical in which the alkyl group is an optionally substituted C1-6 chain; a linear or branched C1-18 alkyl radical optionally substituted with a group selected from -SO3M, -N (R4) 3+ and a group of formula (2), in which: n = 0 or 1; m = 0, 1, 2, 3, or 4; R5, R6, R7, R8 and R9 are the same or different from each other and are selected from an optionally substituted C1-6 alkyl radical, a C1-6 alkoxy radical, an optionally substituted aryl radical and a -OSi (R10) 3 radical ; R10 represents a C1-6 alkyl radical, a C1-6 alkoxy radical or an optionally substituted aryl radical; M is H, Na or K; R4 is an optionally substituted alkyl group; R2 and R3 are the same or different from each other and are selected from hydrogen; optionally substituted, linear or branched alkyl radical, C1-4; and optionally substituted aryl radical; or R2 and R3 are condensed with an optionally heterosubstituted mono- or polycyclic ring system; A1 is a radical of general formula (3) or (4); A2 is a radical of general formula (3), (5) or (6); R11 represents a hydrogen atom; an optionally substituted, linear or branched, saturated or unsaturated alkyl radical, C1-6; a radical -OH; R12 represents a hydrogen atom; a hydroxyl radical; a radical -COOR15; a radical -CONR16R17; an optionally substituted C1-18 alkoxy radical; a phenoxy radical; a C3-7 cycloalkyl radical; a phenyl or naphthyl radical; a phenyl or naphthyl radical bearing 1 or 2 identical or different substituents, such as phenyl, chlorine, C 1-6 alkoxy, C 1-6 alkyl; an alkyl radical, linear or branched, saturated or unsaturated, C1-18, optionally substituted with at least one radical -OH, phenyl or optionally substituted by a group of general formula (2), as defined above; R15, R16 and R17 are the same or different from each other and are selected from hydrogen, an optionally substituted C1-18 alkyl, linear or branched radical; R14 is H or -SO3M, with M as defined above; R13 and R13 'may be the same or different from each other and are selected from hydrogen; optionally substituted C1-18 acyl radical; alkyl radical, linear or branched, saturated or unsaturated, C1-18, optionally substituted with at least one radical -OH, a group -SO3M, a group -N (R4) 3+, where M and R4 as defined above or by a group of general formula (2), as defined above.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200402986A ES2264624B1 (en) | 2004-12-16 | 2004-12-16 | NEW DERIVATIVES OF TRIAZINE, AS WELL AS PROCEDURES FOR THEIR OBTAINING AND ITS USE AS PROTECTIVE AGENTS AGAINST UV RADIATION. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052818A1 true AR052818A1 (en) | 2007-04-04 |
Family
ID=36077586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105267A AR052818A1 (en) | 2004-12-16 | 2005-12-15 | DERIVATIVES OF 6- (1H-PIRAZOL-5-IL) -1,3,5-TRIAZINE, PROCEDURES FOR THE PREPARATION AND USE AS PROTECTIVE AGENTS AGAINST UV RADIATION |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1833818A1 (en) |
| AR (1) | AR052818A1 (en) |
| ES (1) | ES2264624B1 (en) |
| PE (1) | PE20060744A1 (en) |
| TW (1) | TW200637848A (en) |
| UY (1) | UY29280A1 (en) |
| WO (1) | WO2006064366A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008067928A1 (en) * | 2006-12-04 | 2008-06-12 | Isdin S.A. | Uv absorbing compositions containing a pyrrolyltriazine |
| CN101081847B (en) * | 2007-06-15 | 2010-06-09 | 北京大学 | Method for synthesizing N,N-dialkylamine phenyl-dipyrazole triazine structural light-sensitive molecule |
| EP2210887A1 (en) * | 2009-01-14 | 2010-07-28 | Isdin, S.A. | Bis resorcinyl triazine derivatives as protecting agents against UV radiation |
| CN115109466B (en) * | 2022-07-28 | 2023-03-21 | 佛山市帆思科材料技术有限公司 | Anti-aging water-based color ink-jet printing ink product and manufacturing method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3581002D1 (en) * | 1984-06-22 | 1991-02-07 | Ilford Ag | HYDROXYPHENYLTRIAZINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A UV ABSORBER. |
| DE19543730A1 (en) * | 1995-11-23 | 1997-05-28 | Ciba Geigy Ag | Until resorcinyl-triazines |
| EP1482904B1 (en) * | 2002-03-12 | 2008-04-02 | Ciba SC Holding AG | Uv absorber compositions comprising a hydroxyphenyltriazine compound |
| JP4671953B2 (en) * | 2003-01-20 | 2011-04-20 | チバ ホールディング インコーポレーテッド | Triazine derivatives as UV absorbers |
-
2004
- 2004-12-16 ES ES200402986A patent/ES2264624B1/en not_active Withdrawn - After Issue
-
2005
- 2005-12-14 EP EP05823239A patent/EP1833818A1/en not_active Withdrawn
- 2005-12-14 TW TW094144256A patent/TW200637848A/en unknown
- 2005-12-14 PE PE2005001456A patent/PE20060744A1/en not_active Application Discontinuation
- 2005-12-14 WO PCT/IB2005/003931 patent/WO2006064366A1/en active Application Filing
- 2005-12-15 AR ARP050105267A patent/AR052818A1/en not_active Application Discontinuation
- 2005-12-20 UY UY29280A patent/UY29280A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2264624B1 (en) | 2007-11-01 |
| ES2264624A1 (en) | 2007-01-01 |
| PE20060744A1 (en) | 2006-09-10 |
| TW200637848A (en) | 2006-11-01 |
| EP1833818A1 (en) | 2007-09-19 |
| UY29280A1 (en) | 2006-04-28 |
| WO2006064366A1 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |