AR050949A1 - DERIVATIVES OF 5,7-DIHIDRO-1H-IMIDAZOL [4,5-F] INDOL OR [4,5-G] QUINOLIN-6-ONA; ITS DEVELOPMENT AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER - Google Patents

DERIVATIVES OF 5,7-DIHIDRO-1H-IMIDAZOL [4,5-F] INDOL OR [4,5-G] QUINOLIN-6-ONA; ITS DEVELOPMENT AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER

Info

Publication number
AR050949A1
AR050949A1 ARP050103957A ARP050103957A AR050949A1 AR 050949 A1 AR050949 A1 AR 050949A1 AR P050103957 A ARP050103957 A AR P050103957A AR P050103957 A ARP050103957 A AR P050103957A AR 050949 A1 AR050949 A1 AR 050949A1
Authority
AR
Argentina
Prior art keywords
alkyl
formula
preparation
cancer
hydrogen
Prior art date
Application number
ARP050103957A
Other languages
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR050949A1 publication Critical patent/AR050949A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Preparacion de los compuestos mencionados, los medicamentos que los contienen y su elaboracion, así como el uso de los compuestos mencionados para el control o prevencion de enfermedades tales como el cáncer. Reivindicacion 1: El uso de un compuesto de formula (1), donde R1 es hidrogeno, alquilo, o -C(O)-alquilo; R2 es hidrogeno, alquilo, ciano o halogeno; R3 es hidrogeno, alquilo, C3-6-cicloalquilo, alcoxi o alquilsulfanilo; X es -C(O)- o -CH2-; Y es -NH-, -CH2-CR4R5-, -CR4R5-CH2- o - CR4R5-; donde R4 es hidrogeno o alquilo; y R5 es hidrogeno o alquilo; o alternativamente R4 y R5 forman, junto al átomo de carbono al que están unidos, un anillo cicloalquilo; y todas las sales farmacéuticamente aceptables de los mismos; para la elaboracion de un medicamento para el tratamiento del cáncer. Reivindicacion 8: Un proceso para la preparacion de los compuestos de formula (1), donde R1 es un alquilo o -C(O)-alquilo; mediante a) la reaccion de un compuesto de formula (2), donde R1 es un alquilo - C(O)-alquilo y X e Y poseen el significado antes descrito para la formula (1); con un compuesto de formula (3), donde A es -OH, -Cl, -H o -Ome, y R2 y R3 poseen el significado antes descrito para la formula (1); para proporcionar los compuestos de formula (1), donde R1 es un alquilo o -C(O)-alquilo y R2, R3 X e Y poseen el significado antes descrito para la formula (1), b) aislando dicho compuesto de formula (1) a partir de la mezcla de reaccion, y si así se desea, convirtiéndolo en una sal farmacéuticamente aceptable.Preparation of the aforementioned compounds, the medications that contain them and their preparation, as well as the use of the aforementioned compounds for the control or prevention of diseases such as cancer. Claim 1: The use of a compound of formula (1), wherein R 1 is hydrogen, alkyl, or -C (O) -alkyl; R2 is hydrogen, alkyl, cyano or halogen; R3 is hydrogen, alkyl, C3-6-cycloalkyl, alkoxy or alkylsulfanyl; X is -C (O) - or -CH2-; Y is -NH-, -CH2-CR4R5-, -CR4R5-CH2- or - CR4R5-; where R4 is hydrogen or alkyl; and R5 is hydrogen or alkyl; or alternatively R4 and R5 form, together with the carbon atom to which they are attached, a cycloalkyl ring; and all pharmaceutically acceptable salts thereof; for the preparation of a medicine for the treatment of cancer. Claim 8: A process for the preparation of the compounds of formula (1), wherein R 1 is an alkyl or -C (O) -alkyl; by a) the reaction of a compound of formula (2), wherein R 1 is a C-alkyl (O) -alkyl and X and Y have the meaning described above for the formula (1); with a compound of formula (3), where A is -OH, -Cl, -H or -Ome, and R2 and R3 have the meaning described above for formula (1); to provide the compounds of formula (1), wherein R1 is an alkyl or -C (O) -alkyl and R2, R3 X and Y have the meaning described above for formula (1), b) by isolating said compound of formula ( 1) from the reaction mixture, and if so desired, converting it into a pharmaceutically acceptable salt.

ARP050103957A 2004-09-24 2005-09-21 DERIVATIVES OF 5,7-DIHIDRO-1H-IMIDAZOL [4,5-F] INDOL OR [4,5-G] QUINOLIN-6-ONA; ITS DEVELOPMENT AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER AR050949A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04022753 2004-09-24
EP05010528 2005-05-13

Publications (1)

Publication Number Publication Date
AR050949A1 true AR050949A1 (en) 2006-12-06

Family

ID=35429559

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103957A AR050949A1 (en) 2004-09-24 2005-09-21 DERIVATIVES OF 5,7-DIHIDRO-1H-IMIDAZOL [4,5-F] INDOL OR [4,5-G] QUINOLIN-6-ONA; ITS DEVELOPMENT AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER

Country Status (10)

Country Link
EP (1) EP1793822A1 (en)
JP (1) JP2008514565A (en)
KR (1) KR100845749B1 (en)
AR (1) AR050949A1 (en)
AU (1) AU2005287459A1 (en)
CA (1) CA2580203A1 (en)
MX (1) MX2007003463A (en)
RU (1) RU2007115159A (en)
TW (1) TW200626149A (en)
WO (1) WO2006032519A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1879894A1 (en) * 2005-04-14 2008-01-23 F.Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
KR20080063833A (en) * 2005-12-15 2008-07-07 에프. 호프만-라 로슈 아게 Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents
US20090291968A1 (en) * 2006-03-23 2009-11-26 Guy Georges Substituted indazole derivatives, their manufacture and use as pharmaceutical agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
DE3501497A1 (en) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim NEW PYRROLO-BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS
DE3740985A1 (en) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh USE OF LINEAR FURNISHED TRICYCLES AS AN INHIBITORS OF THE ERYTHROCYTE AGGREGATION

Also Published As

Publication number Publication date
WO2006032519A1 (en) 2006-03-30
RU2007115159A (en) 2008-11-10
JP2008514565A (en) 2008-05-08
KR100845749B1 (en) 2008-07-11
MX2007003463A (en) 2007-05-23
EP1793822A1 (en) 2007-06-13
CA2580203A1 (en) 2006-03-30
AU2005287459A1 (en) 2006-03-30
TW200626149A (en) 2006-08-01
KR20070045339A (en) 2007-05-02

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