AR050097A1 - USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY - Google Patents

USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY

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Publication number
AR050097A1
AR050097A1 ARP050103246A AR050097A1 AR 050097 A1 AR050097 A1 AR 050097A1 AR P050103246 A ARP050103246 A AR P050103246A AR 050097 A1 AR050097 A1 AR 050097A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
heterocyclyl
azydyl
aryl
group
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Brigitte Koch
Christine Rauschkolb-Loeffler
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Priority to ARP050103246 priority Critical patent/AR050097A1/en
Publication of AR050097A1 publication Critical patent/AR050097A1/en

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Abstract

Reivindicacion 1: Uso de un compuesto que tiene la formula (1), donde R es hidrogeno, alquilo inferior, alquenilo inferior, alquinilo inferior, arilo, aril(alquilo inferior), heterociclilo, heterociclil(alquilo inferior), (alquil inferior)heterociclilo, cicloalquilo inferior o (cicloalquil inferior)alquilo inferior, y R está no sustituido o está sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; R1 es hidrogeno o alquilo inferior, alquenilo inferior, alquinilo inferior, aril(alquilo inferior), arilo, heterociclil(alquilo inferior), (alquil inferior)heterociclilo, heterociclilo, cicloalquilo inferior, (cicloalquil inferior)alquilo inferior, cada uno no sustituido o sustituido con al menos un grupo dador de electrones y/o al menos un grupo aceptor de electrones; R2 y R3 son independientemente hidrogeno, alquilo inferior, alquenilo inferior, alquinilo inferior, aril(alquilo inferior), arilo, halo, heterociclilo, heterociclil(alquilo inferior), (alquil inferior)heterociclilo, cicloalquilo inferior, (cicloalquil inferior)alquilo inferior o Z-Y, donde R2 y R3 pueden estar no sustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; y donde en R2 y R3 heterociclilo es furilo, tienilo, pirazolilo, pirrolilo, metilpirrolilo, imidazolilo, indolilo, triazolilo, oxazolilo, isotiazolilo, isoxazolilo, piperidilo, pirrolinilo, piperazinilo, quinolilo, triazolilo, tetrazolilo, isoquinolilo, benzofurilo, benzotienilo, morfolinilo, benzoxazolilo, tetrahidrofurilo, piranilo, indazolilo, purinilo, indolinilo, pirazolindinilo, imidazolinilo, imidazolindinilo, pirrolidinilo, furazanilo, N-metilindolilo, metilfurilo, piridazinilo, pirimidinilo, pirazinilo, piridilo, epoxi, aziridino, oxetanilo, azetidinilo, o, cuando N está presente en el heterociclilo, un N-oxido de los mismos; Z es O, S, S(O)a, NR4, NR6' o PR4 o un enlace químico; Y es hidrogeno, alquilo inferior, arilo, aril(alquilo inferior); alquenilo inferior, alquinilo inferior, halo, heterociclilo, heterociclil(alquilo inferior), (alquil inferior)heterociclilo e Y puede estar no sustituido o sustituido con al menos un grupo dador de electrones y/o al menos un grupo aceptor de electrones, donde heterociclilo tiene el mismo significado como R2 o R3 y con la condicion de que cuando Y es halo, entonces Z es un enlace químico; o Z e Y tomados conjuntamente como ZY son NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7 o N+R5R6R7, o una formula (2); R6' es hidrogeno, alquilo inferior, alquenilo inferior o alquinilo inferior que pueden estar no sustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; R4, R5 y R6 son independientemente hidrogeno, alquilo inferior, arilo, aril(alquil inferior), alquenilo inferior o alquinilo inferior, donde R4, R5 y R6 independientemente pueden estar no sustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; y R7 es R6 o COOR8 o COR8, pudiendo R7 estar no sustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; R8 es hidrogeno o alquilo inferior, o aril(alquilo inferior), y el grupo arilo o alquilo puede estar no sustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo dador de electrones; y n es 1-4; y a es 1-3; o de una sal farmacéuticamente aceptable del mismo, caracterizado, porque dicho uso es para la preparacion de una composicion farmacéutica util para la prevencion, el alivio y/o el tratamiento de dolor asociado con neuropatía diabética dolorosa. Reivindicacion 2: Uso de acuerdo con la reivindicacion 1, caracterizado porque el dolor asociado con neuropatía diabética dolorosa es un dolor asociado con polineuropatía sensoria distal diabética.Claim 1: Use of a compound having the formula (1), wherein R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl (lower alkyl), heterocyclyl, heterocyclyl (lower alkyl), (lower alkyl) heterocyclyl , lower cycloalkyl or (lower cycloalkyl) lower alkyl, and R is unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; R1 is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl (lower alkyl), aryl, heterocyclyl (lower alkyl), (lower alkyl) heterocyclyl, heterocyclyl, lower cycloalkyl, (lower cycloalkyl) lower alkyl, each unsubstituted or substituted with at least one electron donor group and / or at least one electron acceptor group; R2 and R3 are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl (lower alkyl), aryl, halo, heterocyclyl, heterocyclyl (lower alkyl), (lower alkyl) heterocyclyl, lower cycloalkyl, (lower cycloalkyl) lower alkyl or ZY, where R2 and R3 may be unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; and where R2 and R3 heterocyclyl is furyl, thienyl, pyrazolyl, pyrrolyl, methylpyrrolyl, imidazolyl, indolyl, triazolyl, oxazolyl, isothiazolyl, isoxazolyl, piperidyl, pyrrolinyl, piperazinyl, quinolyl, triazolyl, tetrazolyl, isoquinolyl, benzofuryl, benzothienyl, morpholinyl, benzoxazolyl, tetrahydrofuryl, pyranyl, indazolyl, purinyl, indolinyl, pyrazolindinyl, imidazolinyl, imidazolindinyl, pyrrolidinyl, furazanyl, N-methylindolyl, methylfuryl, pyridazinyl, pyrimidinyl, pyrazinyl, pyridyl, azyridyl, azydyl, azetyl, azydyl, azethyl, azethyl, azethyl, ethyloid, azydyl, azydyl, ethyloid, azydyl, azydyl, ethyloid, azydyl, ethyloid, azydyl, ethyloid, azydyl, ethyloid, azydyl, ethyloid, azydyl, ethyloid, azydyl, ethyloxy, nyl, ethyloxyl, ethyloxy, ethyloxy, ethyloxyl, azytyl, ethyloxy, ethyloxy, ethyloxy, azexyl, ethyloxyl, ethyloxy, ethyloxy, ethoxy; in the heterocyclyl, an N-oxide thereof; Z is O, S, S (O) a, NR4, NR6 'or PR4 or a chemical bond; Y is hydrogen, lower alkyl, aryl, aryl (lower alkyl); lower alkenyl, lower alkynyl, halo, heterocyclyl, heterocyclyl (lower alkyl), (lower alkyl) heterocyclyl and Y may be unsubstituted or substituted with at least one electron donor group and / or at least one electron acceptor group, where heterocyclyl it has the same meaning as R2 or R3 and with the proviso that when Y is halo, then Z is a chemical bond; or Z and Y taken together as ZY are NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7 or N + R5R6R7, or a formula (2); R 6 'is hydrogen, lower alkyl, lower alkenyl or lower alkynyl which may be unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; R4, R5 and R6 are independently hydrogen, lower alkyl, aryl, aryl (lower alkyl), lower alkenyl or lower alkynyl, where R4, R5 and R6 can independently be unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; and R7 is R6 or COOR8 or COR8, R7 being able to be unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; R8 is hydrogen or lower alkyl, or aryl (lower alkyl), and the aryl or alkyl group may be unsubstituted or substituted with at least one electron acceptor group and / or at least one electron donor group; and n is 1-4; and a is 1-3; or of a pharmaceutically acceptable salt thereof, characterized in that said use is for the preparation of a pharmaceutical composition useful for the prevention, relief and / or treatment of pain associated with painful diabetic neuropathy. Claim 2: Use according to claim 1, characterized in that the pain associated with painful diabetic neuropathy is pain associated with diabetic distal sensory polyneuropathy.

ARP050103246 2005-08-04 2005-08-04 USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY AR050097A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP050103246 AR050097A1 (en) 2005-08-04 2005-08-04 USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP050103246 AR050097A1 (en) 2005-08-04 2005-08-04 USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY

Publications (1)

Publication Number Publication Date
AR050097A1 true AR050097A1 (en) 2006-09-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103246 AR050097A1 (en) 2005-08-04 2005-08-04 USE OF PEPTIDIC COMPOUNDS TO TREAT PAIN IN PAINFUL DIABETIC NEUROPATHY

Country Status (1)

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AR (1) AR050097A1 (en)

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