AR049425A1

AR049425A1 - N- SULFAMOIL -N'- ARILPIPERAZINAS, PROCEDURE FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND ITS USE FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITIONS

Info

Publication number: AR049425A1
Authority: AR
Inventors: Jochen Antel; Michael Firnges; Peter-Colin Gregory; Uwe Reinecker; Uwe Schon; Harald Waldeck; Michael Wurl; Dania Reiche
Original assignee: Solvay Pharm Gmbh
Priority date: 2004-05-19
Filing date: 2005-05-16
Publication date: 2006-08-02
Also published as: TW200602057A; UA86416C2

Abstract

La presente trata de N-sulfamoil-N'-arilpiperazinas, procedimientos para su preparacion, composicion farmacéutica, y su uso para la preparacion de dichas composiciones farmacéuticas, composicion farmacéutica que los comprende. Reivindicacion 1: Uso de un compuesto de la formula (1) en la cual Ar representa un radical C6-10-arilo, monocíclico o bicíclico, cuyos átomos de carbono cíclicos están opcionalmente reemplazados una a tres veces por nitrogeno, oxígeno y/o azufre, y/o cuyo sistema cíclico C6-10-arilo contiene opcionalmente tres a cinco dobles ligaduras y/o cuyo sistema cíclico C6-10-arilo está opcionalmente sustituido con uno, dos o tres sustituyentes que pueden ser iguales o distintos entre sí y que están elegidos del grupo que comprende halogeno, carboxilo, hidroxilo, hidroxicarbamoilo, trifluorometil, ciano, nitro, pirrolidinilo, C1-4-alquilo, C1-4-alcoxi, C0-4-alcoxifenilo, C1-4-alquiltio, C2-4-alcanoilo, C1-4-alquiloxicarbonilo, C1-4-alquilsulfonilo, y dos átomos de oxígeno ligados a dos átomos de carbono adyacentes del sistema cíclico C6-10-arilo y que están puenteados por C1-2-alquileno; o cuyo sistema cíclico C6-10- arilo está sustituido con uno o dos sustituyentes que pueden ser iguales o distintos entre sí y elegidos del grupo que comprende halogeno, carboxilo, hidroxilo, hidroxicarbamoilo, trifluorometilo, ciano, nitro, C1-4-alquilo, C1-4-alcoxi, C1-4-alquiltio, C2-4-alcanoilo, C1-4-alquiloxicarbonilo, C1-4-alquil-sulfonilo, dos átomos de oxígeno ligados a dos átomos de carbono adyacentes del sistema cíclico C6-10-arilo y puenteados por C1-2-alquileno; o cuyo sistema cíclico C6-10-arilo está sustituido con tienilo, naftilo, piridilo, fenilo o bencilo, cada uno de cuyos sustituyentes fenilo o bencilo están opcionalmente sustituido en el ciclo fenilo con uno, dos o tres sustituyentes pueden ser iguales o distintos entre sí y elegidos del grupo que comprende halogeno, trifluorometilo, ciano, C1-6-alquilo, C1-4-alcoxi o C1-4- alquilsulfonilo, o sus sales de adicion de ácido fisiologicamente compatibles, para la preparacion de un medicamento para el tratamiento y/o profilaxis de obesidad y sus condiciones o enfermedades secundarias y/o concomitantes.This is about N-sulfamoyl-N'-arylpiperazines, processes for their preparation, pharmaceutical composition, and their use for the preparation of said pharmaceutical compositions, pharmaceutical composition comprising them. Claim 1: Use of a compound of the formula (1) in which Ar represents a C6-10-aryl, monocyclic or bicyclic radical, whose cyclic carbon atoms are optionally replaced one to three times by nitrogen, oxygen and / or sulfur , and / or whose C6-10-aryl cyclic system optionally contains three to five double ligatures and / or whose C6-10-aryl cyclic system is optionally substituted with one, two or three substituents that may be the same or different from each other and that are chosen from the group comprising halogen, carboxyl, hydroxyl, hydroxycarbamoyl, trifluoromethyl, cyano, nitro, pyrrolidinyl, C1-4-alkyl, C1-4-alkoxy, C0-4-alkoxyphenyl, C1-4-alkylthio, C2-4- alkanoyl, C1-4-alkyloxycarbonyl, C1-4-alkylsulfonyl, and two oxygen atoms linked to two adjacent carbon atoms of the C6-10-aryl cyclic system and which are bridged by C1-2-alkylene; or whose C6-10-aryl cyclic system is substituted with one or two substituents that may be the same or different from each other and chosen from the group comprising halogen, carboxyl, hydroxyl, hydroxycarbamoyl, trifluoromethyl, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, C1-4-alkylthio, C2-4-alkanoyl, C1-4-alkyloxycarbonyl, C1-4-alkyl sulfonyl, two oxygen atoms linked to two adjacent carbon atoms of the C6-10- cyclic system aryl and bridged by C1-2-alkylene; or whose C6-10-aryl cyclic system is substituted with thienyl, naphthyl, pyridyl, phenyl or benzyl, each of whose phenyl or benzyl substituents are optionally substituted in the phenyl cycle with one, two or three substituents may be the same or different from yes and chosen from the group comprising halogen, trifluoromethyl, cyano, C1-6-alkyl, C1-4-alkoxy or C1-4-alkylsulfonyl, or their physiologically compatible acid addition salts, for the preparation of a medicament for the treatment and / or obesity prophylaxis and its secondary and / or concomitant conditions or diseases.