AR049301A1 - PROCEDURE FOR THE PREPARATION OF DIARILISOXAZOL SULFONAMIDE COMPOUNDS AND INTERMEDIATE PRODUCTS - Google Patents

PROCEDURE FOR THE PREPARATION OF DIARILISOXAZOL SULFONAMIDE COMPOUNDS AND INTERMEDIATE PRODUCTS

Info

Publication number
AR049301A1
AR049301A1 ARP050102396A ARP050102396A AR049301A1 AR 049301 A1 AR049301 A1 AR 049301A1 AR P050102396 A ARP050102396 A AR P050102396A AR P050102396 A ARP050102396 A AR P050102396A AR 049301 A1 AR049301 A1 AR 049301A1
Authority
AR
Argentina
Prior art keywords
group
preparation
sulfonamide compounds
alkyl
formula
Prior art date
Application number
ARP050102396A
Other languages
Spanish (es)
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR049301A1 publication Critical patent/AR049301A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

La presente trata de un procedimiento para la preparcion de compuestos de diarilisoxazol sulfonamida y productos intermedios como 3,4difenil-4-pirrolidin-1-il-but-3-en-ona. Reivindicacion 1: Un procedimiento para la preparacion de un compuesto diarilhidroxiisoxazol que tiene la estructura de formula (1), en la que el procedimiento comprende poner en contacto un compuesto de diarilenamina cetona que tiene la estructura de formula (2), con hidroxilamina en presencia de una base, de forma que se forma el compuesto de diarilhidroxiisoxazol, donde R1 se selecciona del grupo constituido por H y alquilo; R2, R3, R4, R5, R6, R7, R8, R9, R10 y R11 se seleccionan cada uno de forma independiente del grupo constituido por H, alquilo, aminosulfonilo, y un grupo aminosulfonilo protegido; donde el grupo aminosulfonilo protegido tiene la estructura de formula (3), R13 es un grupo amino protegido; y R12 es un heterociclo que contiene N opcionalmente sustituido con un resto seleccionado del grupo constituido por alquilo, alquenilo y alquinilo; y donde un átomo de N del heterociclo que contiene N es parte de la estructura enamina del compuesto de diarilenamina cetona.This is a process for the preparation of diarylisoxazole sulfonamide compounds and intermediates such as 3,4-diphenyl-4-pyrrolidin-1-yl-but-3-en-one. Claim 1: A process for the preparation of a diarylhydroxyisoxazole compound having the structure of formula (1), wherein the process comprises contacting a diarylenamine ketone compound having the structure of formula (2), with hydroxylamine in the presence of a base, so that the diarylhydroxyisoxazole compound is formed, where R1 is selected from the group consisting of H and alkyl; R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each independently selected from the group consisting of H, alkyl, aminosulfonyl, and a protected aminosulfonyl group; wherein the protected aminosulfonyl group has the structure of formula (3), R13 is a protected amino group; and R12 is an N-containing heterocycle optionally substituted with a moiety selected from the group consisting of alkyl, alkenyl and alkynyl; and where an N atom of the N-containing heterocycle is part of the enamine structure of the diarylenamine ketone compound.

ARP050102396A 2004-06-14 2005-06-13 PROCEDURE FOR THE PREPARATION OF DIARILISOXAZOL SULFONAMIDE COMPOUNDS AND INTERMEDIATE PRODUCTS AR049301A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57959104P 2004-06-14 2004-06-14

Publications (1)

Publication Number Publication Date
AR049301A1 true AR049301A1 (en) 2006-07-12

Family

ID=34972271

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102396A AR049301A1 (en) 2004-06-14 2005-06-13 PROCEDURE FOR THE PREPARATION OF DIARILISOXAZOL SULFONAMIDE COMPOUNDS AND INTERMEDIATE PRODUCTS

Country Status (3)

Country Link
AR (1) AR049301A1 (en)
TW (1) TW200616983A (en)
WO (1) WO2005123701A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172583A (en) * 2013-03-07 2013-06-26 深圳市资福药业有限公司 Parecoxib preparation method
CN104250232A (en) * 2013-06-26 2014-12-31 四川唯拓生物医药有限公司 Preparation method of parecoxib sodium
CN104447600B (en) * 2013-09-22 2016-03-30 江苏奥赛康药业股份有限公司 A kind of Preparation Method And Their Intermediate impurity of Parecoxib sodium compound, preparation method and application
CN105085425B (en) * 2014-05-23 2018-01-30 昆药集团股份有限公司 A kind of method for preparing SC 69124
CN104193694B (en) * 2014-09-19 2016-08-24 成都欣捷高新技术开发有限公司 A kind of method preparing Parecoxib Sodium intermediate
CN105801508B (en) * 2014-12-30 2018-12-11 上海鼎雅药物化学科技有限公司 The preparation method of SC 69124
CN106146424A (en) * 2015-03-23 2016-11-23 上海医药工业研究院 A kind of preparation method of 5-methyl-3,4-diphenyl isoxazole
CN105418528B (en) * 2015-12-31 2018-08-24 山东罗欣药业集团股份有限公司 A kind of preparation method of Parecoxib Sodium
CN106008388B (en) * 2016-05-25 2018-06-26 吴兴龙 A kind of preparation method for the SC 69124 for being used to treat postoperative pain
CN106008386B (en) * 2016-05-25 2018-11-06 台州宝诚科技服务有限公司 A method of preparing the SC 69124 for treating postoperative pain
CN110305071A (en) * 2019-07-23 2019-10-08 成都通德药业有限公司 A kind of synthetic method of Parecoxib Sodium intermediate SC 69124
CN110790745A (en) * 2019-11-12 2020-02-14 青岛科技大学 Preparation method for extracting vitacoxib from waste tablets
CN111153866A (en) * 2020-01-19 2020-05-15 上海臣邦医药科技股份有限公司 Parecoxib sodium disubstituted impurity and preparation method and application thereof
CN111153865A (en) * 2020-01-19 2020-05-15 上海臣邦医药科技股份有限公司 Parecoxib sodium substituted impurity and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3267300B2 (en) * 1995-02-13 2002-03-18 ジー．ディー．サール アンド カンパニー Substituted isoxazoles for the treatment of inflammation
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
TW200616983A (en) 2006-06-01
WO2005123701A1 (en) 2005-12-29

Similar Documents

Publication Publication Date Title
AR049301A1 (en) PROCEDURE FOR THE PREPARATION OF DIARILISOXAZOL SULFONAMIDE COMPOUNDS AND INTERMEDIATE PRODUCTS
DOP2011000061A (en) PIRROL COMPOUNDS
AR058554A1 (en) HITEROCICLIC COMPOUNDS NITROGENATED OF 6 SUBSTITUTED MEMBERS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY MGLUR5.
CO5721002A2 (en) ACID DERIVATIVES 3- (4-BENCILOXIFENIL) PROPANOIC
EA201170096A1 (en) SUBSTITUTED PYRIMIDON DERIVATIVES
ECSP045317A (en) PYRIDINOILPIPERIDINS AS AGONISTS OF 5-HT1F
AR059314A1 (en) DERIVATIVES OF BENZAMIDS AND HETEROARANS
CO6160266A2 (en) DERIVATIVE OF OXOPIRAZINE AND HERBICIDE
CO5580788A2 (en) BENCIMIDAZOL COMPOUNDS REPLACED USEFUL AS PROTEIN CINASE INHIBITORS
CR8468A (en) DERIVED FROM N- (1,5-DIFENIL-1H-PIRAZOL-3-IL) METHYL) SULFONAMIDE AFFECTED BY CB1 RECEIVERS
IN2012DN04853A (en)
CO5580765A2 (en) SPIROCICLIC CYCLHEXAN DERIVATIVES
NO20071642L (en) N-Benzenesulfonyl-substituted anilino-pyrimidine analogs
AR054102A1 (en) DERIVATIVES OF FENIL-PIPERAZINA-METANONA. PROCESSES OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS
AR051403A1 (en) DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA AS INHIBITORS OF THE ACTIVITY OF PROTEIN QUINASA; METHODS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATIONED BY PROTEIN KINASE A AND B.
PE20070078A1 (en) MACROCICLIC HETEROCYCLIC COMPOUNDS AS ASPARTILE PROTEASE INHIBITORS
AR055144A1 (en) ACID SECRETION INHIBITOR
CO5700721A2 (en) SUBSTITUTED QUINOLINE COMPOUNDS
CR9221A (en) PROCESSES TO PREPARE AROMATIC ETERES
AR053342A1 (en) QUINOLONAS Y NAFTIRIDONAS 7- MAINO ALQUILILDENIL- HETEROCICLICAS
AR031597A1 (en) PIPERIDINE COMPOUNDS, A PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS, AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR USE AS CCR-3 INHIBITORS
NI200800247A (en) DERIVATIVES OF 1,2,4,5-TETRAHIDRO-3H-BENZAZEPINEAS, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ECSP077982A (en) PROCESS FOR THE SYNTHESIS OF 5- (METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFLUOROMETIL) -BENCENAMINE
TW200726470A (en) 6,7-unsaturated-7-carbamoylmorphinan derivatives
TW200609224A (en) Organic compounds

Legal Events

Date Code Title Description
FB Suspension of granting procedure