AR046661A1 - PROCESS FOR THE PREPARATION OF TAMSULOSINE - Google Patents

PROCESS FOR THE PREPARATION OF TAMSULOSINE

Info

Publication number
AR046661A1
AR046661A1 ARP040104334A AR046661A1 AR 046661 A1 AR046661 A1 AR 046661A1 AR P040104334 A ARP040104334 A AR P040104334A AR 046661 A1 AR046661 A1 AR 046661A1
Authority
AR
Argentina
Prior art keywords
formula
preparation
tamsulosin
tamsulosine
methoxybenzenesulfonamide
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Hot Lun Allan Tse
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Publication of AR046661A1 publication Critical patent/AR046661A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un proceso para la preparación de (R)-5-[2-[[2-(2-etoxifenoxi)etil]amino]propil]-2-metoxibencenosulfonamida (tamsulosina) la cual presenta la fórmula (1), y sales farmacéuticamente aceptables de la misma, lo cual comprende acoplar un éster que presente la fórmula (2), caracterizado porque R es un alquilo, con (R)-5-(2-amino)propil-2-metoxi-bencenosulfonamida la cual presenta la fórmula (3), tamsulosina que presenta la fórmula (4), seguido por una reducción de tal amida 4 para obtener la tamsulosina de la fórmula (1).Claim 1: A process for the preparation of (R) -5- [2 - [[2- (2-ethoxyphenoxy) ethyl] amino] propyl] -2-methoxybenzenesulfonamide (tamsulosin) which has the formula (1), and pharmaceutically acceptable salts thereof, which comprises coupling an ester having the formula (2), characterized in that R is an alkyl, with (R) -5- (2-amino) propyl-2-methoxybenzenesulfonamide which has the formula (3), tamsulosin having the formula (4), followed by a reduction of such amide 4 to obtain the tamsulosin of the formula (1).

ARP040104334 2003-11-26 2004-11-23 PROCESS FOR THE PREPARATION OF TAMSULOSINE AR046661A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2451175 CA2451175A1 (en) 2003-11-26 2003-11-26 Process for the preparation of tamsulosin

Publications (1)

Publication Number Publication Date
AR046661A1 true AR046661A1 (en) 2005-12-14

Family

ID=34596843

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104334 AR046661A1 (en) 2003-11-26 2004-11-23 PROCESS FOR THE PREPARATION OF TAMSULOSINE

Country Status (3)

Country Link
AR (1) AR046661A1 (en)
CA (1) CA2451175A1 (en)
WO (1) WO2005051897A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258394B1 (en) * 2004-12-31 2007-12-01 Quimica Sintetica, S.A. ENZYMATIC PROCEDURE FOR THE PREPARATION OF AN INTERMEDIATE COMPOUND AND ITS USE IN THE SYNTHESIS OF TAMSULOSINE CHLORHYDRATE.
FR2880887B1 (en) * 2005-01-14 2009-01-30 Merck Sante Soc Par Actions Si HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND THERAPEUTIC APPLICATIONS
WO2007086074A2 (en) * 2006-01-27 2007-08-02 Usv Limited A process for the preparation of r (-) tamsulosin hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56110665A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
KR100525493B1 (en) * 2001-02-23 2005-11-02 연성정밀화학(주) Process for preparing sulfamoyl-substituted phenethylamine derivatives

Also Published As

Publication number Publication date
WO2005051897A1 (en) 2005-06-09
CA2451175A1 (en) 2005-05-26

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