AR046070A1 - SIBUTRAMINE AS A FREE BASE IN CRYSTAL FORM AND SALTS, COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME - Google Patents

SIBUTRAMINE AS A FREE BASE IN CRYSTAL FORM AND SALTS, COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME

Info

Publication number
AR046070A1
AR046070A1 ARP040101493A ARP040101493A AR046070A1 AR 046070 A1 AR046070 A1 AR 046070A1 AR P040101493 A ARP040101493 A AR P040101493A AR P040101493 A ARP040101493 A AR P040101493A AR 046070 A1 AR046070 A1 AR 046070A1
Authority
AR
Argentina
Prior art keywords
sibutramine
free base
salts
compositions
contain
Prior art date
Application number
ARP040101493A
Other languages
Spanish (es)
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of AR046070A1 publication Critical patent/AR046070A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Abstract

Reivindicación 1: Sibutramina, N-{ 1-[1-(4-clorofeni)ciclobutil]-3-metilbutil}-N, N-dimetil-amina, como base libre, caracterizada porque está en forma cristalina Reivindicación 2: Sibutramina como base libre, caracterizada porque en forma cristalina, tiene el patrón de difracción de rayos X mostrado en la figura 1, o un patrón de difracción de rayos X sustancialmetne similar al mostrado en la figura 1.Claim 1: Sibutramine, N- {1- [1- (4-chloropheni) cyclobutyl] -3-methylbutyl} -N, N-dimethyl amine, as a free base, characterized in that it is in crystalline form Claim 2: Sibutramine as a base free, characterized in that in crystalline form, it has the X-ray diffraction pattern shown in Figure 1, or an X-ray diffraction pattern substantially similar to that shown in Figure 1.

ARP040101493A 2003-05-06 2004-04-30 SIBUTRAMINE AS A FREE BASE IN CRYSTAL FORM AND SALTS, COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME AR046070A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0310361.1A GB0310361D0 (en) 2003-05-06 2003-05-06 Pharmaceutical compound

Publications (1)

Publication Number Publication Date
AR046070A1 true AR046070A1 (en) 2005-11-23

Family

ID=9957512

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101493A AR046070A1 (en) 2003-05-06 2004-04-30 SIBUTRAMINE AS A FREE BASE IN CRYSTAL FORM AND SALTS, COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME

Country Status (7)

Country Link
EP (1) EP1620388A1 (en)
KR (1) KR20060034636A (en)
AR (1) AR046070A1 (en)
CL (1) CL2004000948A1 (en)
GB (1) GB0310361D0 (en)
PA (1) PA8602001A1 (en)
WO (1) WO2004099119A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432398B2 (en) * 2005-01-06 2008-10-07 Cj Corporation Inorganic acid salts of sibutramine
KR100814384B1 (en) * 2006-02-10 2008-03-18 대화제약 주식회사 Pharmaceutical composition containing sibutramine salt, and manufacturing method thereof
KR100806673B1 (en) * 2006-06-23 2008-03-03 주식회사 대희화학 Process for Preparing Crystalline Sibutramine Free Base

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821577B (en) * 1981-04-06 1983-03-30 Boots Co Plc Therapeutic agents
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound

Also Published As

Publication number Publication date
CL2004000948A1 (en) 2005-04-22
EP1620388A1 (en) 2006-02-01
GB0310361D0 (en) 2003-06-11
WO2004099119A1 (en) 2004-11-18
PA8602001A1 (en) 2004-11-26
KR20060034636A (en) 2006-04-24

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal