AR046057A1 - USE OF CERTAIN PIRIMID (1,2-A) INDOLES FOR WEIGHT REDUCTION - Google Patents
USE OF CERTAIN PIRIMID (1,2-A) INDOLES FOR WEIGHT REDUCTIONInfo
- Publication number
- AR046057A1 AR046057A1 ARP040103635A ARP040103635A AR046057A1 AR 046057 A1 AR046057 A1 AR 046057A1 AR P040103635 A ARP040103635 A AR P040103635A AR P040103635 A ARP040103635 A AR P040103635A AR 046057 A1 AR046057 A1 AR 046057A1
- Authority
- AR
- Argentina
- Prior art keywords
- straight
- carbon atoms
- branched chain
- optionally substituted
- chain alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Abstract
Reivindicación 1: Uso de los compuestos, de fórmula (1), en la que: A, D, E, L y M son idénticos o diferentes y representan hidrógeno, halógeno, trifluorometilo, carboxi, hidroxi, alcoxi o alcoxicarbonilo de cadena lineal o ramificada con, en cada caso, hasta 6 átomos de carbono o alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, que por su parte, puede estar sustituido con hidroxi o con alcoxi de cadena lineal o ramificada con hasta 4 átomos de carbono; R1 y R2 son idénticos o diferentes y representan hidrógeno, cicloalquilo C3-8 de carbono o alquilo de cadena lineal o ramificada con hasta 10 átomos de carbono, el cual está opcionalmente sustituido con cicloalquilo C3-6, o representa fenilo, el cual está opcionalmente sustituido con halógeno o trifluorometilo; o R1 y R2 forman, con el átomo de carbono un anillo cicloalquilo de 4 a 8 miembros; y R3 representa fenilo, el cual está opcionalmente sustituido hasta 3 veces, de forma idéntica o diferente, por nitro, carboxi, halógeno, ciano o con alquenilo o alcoxicarbonilo de cadena lineal o ramificada con, en cada caso, hasta 6 átomo de carbono o con alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, el cual está opcionalmente sustituido con hidroxi, carboxi o con alcoxi o alcoxicarbonilo de cadena lineal o ramificada con, en cada caso, hasta 6 átomos de carbono; y/o, está opcionalmente sustituido con un grupo de fórmula -OR4 ó -NR5R6, en la que R4 significa hidrógeno o alquilo o alquenilo de cadena lineal o ramificada con, en cada caso, hasta 6 átomos de carbono; R5 y R6 son idénticos o diferentes y significan fenilo, hidrógeno o alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, o significan acilo de cadena lineal o ramificada con hasta 8 átomos de carbono, el cual está opcionalmente sustituido con un grupo de fórmula -NR7R8, en el que R7 y R8 son idénticos o diferentes, y significan hidrógeno o acilo de cadena lineal o ramificada con hasta 8 átomos de carbono, para la preparación de medicamentos para la reducción de peso.Claim 1: Use of the compounds of formula (1), wherein: A, D, E, L and M are identical or different and represent hydrogen, halogen, trifluoromethyl, carboxy, hydroxy, alkoxy or alkoxycarbonyl straight chain or branched with, in each case, up to 6 carbon atoms or straight or branched chain alkyl with up to 6 carbon atoms, which in turn can be substituted with hydroxy or with straight or branched chain alkoxy with up to 4 carbon atoms ; R1 and R2 are identical or different and represent hydrogen, C3-8 carbon cycloalkyl or straight or branched chain alkyl with up to 10 carbon atoms, which is optionally substituted with C3-6 cycloalkyl, or represents phenyl, which is optionally substituted with halogen or trifluoromethyl; or R1 and R2 form, with the carbon atom, a 4- to 8-membered cycloalkyl ring; and R3 represents phenyl, which is optionally substituted up to 3 times, identically or differently, by nitro, carboxy, halogen, cyano or with straight or branched chain alkenyl or alkoxycarbonyl with, in each case, up to 6 carbon atom or with straight or branched chain alkyl with up to 6 carbon atoms, which is optionally substituted with hydroxy, carboxy or with straight or branched chain alkoxy or alkoxycarbonyl with, in each case, up to 6 carbon atoms; and / or, is optionally substituted with a group of the formula -OR4 or -NR5R6, wherein R4 means hydrogen or straight or branched chain alkyl or alkenyl with, in each case, up to 6 carbon atoms; R5 and R6 are identical or different and mean phenyl, hydrogen or straight or branched chain alkyl with up to 6 carbon atoms, or mean straight or branched chain acyl with up to 8 carbon atoms, which is optionally substituted with a group of formula -NR7R8, in which R7 and R8 are identical or different, and mean hydrogen or straight or branched chain acyl with up to 8 carbon atoms, for the preparation of medicaments for weight reduction.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10349175A DE10349175A1 (en) | 2003-10-22 | 2003-10-22 | Weight loss agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046057A1 true AR046057A1 (en) | 2005-11-23 |
Family
ID=34442211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103635A AR046057A1 (en) | 2003-10-22 | 2004-10-07 | USE OF CERTAIN PIRIMID (1,2-A) INDOLES FOR WEIGHT REDUCTION |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR046057A1 (en) |
| DE (1) | DE10349175A1 (en) |
| GT (1) | GT200400212A (en) |
| PE (1) | PE20050649A1 (en) |
| TW (1) | TW200528454A (en) |
| WO (1) | WO2005041974A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19613550A1 (en) * | 1996-04-04 | 1997-10-09 | Bayer Ag | New pyrimido [1,2-a] indoles |
-
2003
- 2003-10-22 DE DE10349175A patent/DE10349175A1/en not_active Withdrawn
-
2004
- 2004-10-07 AR ARP040103635A patent/AR046057A1/en unknown
- 2004-10-12 WO PCT/EP2004/011398 patent/WO2005041974A1/en active Application Filing
- 2004-10-19 GT GT200400212A patent/GT200400212A/en unknown
- 2004-10-21 PE PE2004001013A patent/PE20050649A1/en not_active Application Discontinuation
- 2004-10-21 TW TW093131911A patent/TW200528454A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050649A1 (en) | 2005-10-27 |
| WO2005041974A1 (en) | 2005-05-12 |
| TW200528454A (en) | 2005-09-01 |
| DE10349175A1 (en) | 2005-05-19 |
| GT200400212A (en) | 2005-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |