AR044063A1 - PROCESS TO PREPARE AMLODIPINE MONOHIDRATE MESYLATE - Google Patents
PROCESS TO PREPARE AMLODIPINE MONOHIDRATE MESYLATEInfo
- Publication number
- AR044063A1 AR044063A1 ARP040101372A ARP040101372A AR044063A1 AR 044063 A1 AR044063 A1 AR 044063A1 AR P040101372 A ARP040101372 A AR P040101372A AR P040101372 A ARP040101372 A AR P040101372A AR 044063 A1 AR044063 A1 AR 044063A1
- Authority
- AR
- Argentina
- Prior art keywords
- mesylate
- amlodipine
- monohidrate
- prepare amlodipine
- prepare
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title abstract 4
- 229960000528 amlodipine Drugs 0.000 title abstract 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
- 239000012458 free base Substances 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- OIXMUQLVDNPHNS-UHFFFAOYSA-N methanesulfonic acid;hydrate Chemical compound O.CS(O)(=O)=O OIXMUQLVDNPHNS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se prepara mesilato de amlodipina monohidrato ya sea a partir de mesilato de amlodipina anhidro o en presencia de un medio disolvente inmiscible en agua de la base libre de amlodipina y ácido metansulfónico.Amlodipine monohydrate mesylate is prepared either from anhydrous amlodipine mesylate or in the presence of a water immiscible solvent medium from the free base of amlodipine and methanesulfonic acid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0309471A GB0309471D0 (en) | 2003-04-25 | 2003-04-25 | Process |
| GB0314617A GB0314617D0 (en) | 2003-06-23 | 2003-06-23 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044063A1 true AR044063A1 (en) | 2005-08-24 |
Family
ID=33420880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101372A AR044063A1 (en) | 2003-04-25 | 2004-04-22 | PROCESS TO PREPARE AMLODIPINE MONOHIDRATE MESYLATE |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR044063A1 (en) |
| CL (1) | CL2004000864A1 (en) |
| DE (1) | DE112004000712T5 (en) |
| GB (1) | GB2415696B (en) |
| PA (1) | PA8601501A1 (en) |
| WO (1) | WO2004096770A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152013C (en) * | 2001-11-22 | 2004-06-02 | 张喜田 | Levo-amlodipine salt able to generate hydrate and its hydrate and preparation |
| CN112538044B (en) * | 2019-12-09 | 2021-08-13 | 昆明赛诺制药股份有限公司 | Amlodipine mesylate monohydrate, and preparation method and application thereof |
| US20230023131A1 (en) * | 2019-12-09 | 2023-01-26 | Kunming Sinoway Natural Pharmaceuticals Co., Ltd. | Amlodipine mesylate monohydrate preparation method therefor and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (en) * | 1982-03-11 | 1991-12-09 | Pfizer | CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy |
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| EP1221438B1 (en) * | 2001-01-09 | 2007-03-14 | Siegfried Generics International AG | Amlodipine mesylate salts |
-
2004
- 2004-04-16 WO PCT/GB2004/001638 patent/WO2004096770A1/en active Application Filing
- 2004-04-16 GB GB0522075A patent/GB2415696B/en not_active Expired - Fee Related
- 2004-04-16 DE DE112004000712T patent/DE112004000712T5/en not_active Withdrawn
- 2004-04-22 AR ARP040101372A patent/AR044063A1/en unknown
- 2004-04-23 CL CL200400864A patent/CL2004000864A1/en unknown
- 2004-04-23 PA PA20048601501A patent/PA8601501A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2415696B (en) | 2007-06-20 |
| GB0522075D0 (en) | 2005-12-07 |
| DE112004000712T5 (en) | 2006-10-19 |
| GB2415696A (en) | 2006-01-04 |
| WO2004096770A1 (en) | 2004-11-11 |
| PA8601501A1 (en) | 2004-12-16 |
| CL2004000864A1 (en) | 2005-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |