AR043963A1 - DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO - Google Patents
DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TOInfo
- Publication number
- AR043963A1 AR043963A1 ARP040101128A ARP040101128A AR043963A1 AR 043963 A1 AR043963 A1 AR 043963A1 AR P040101128 A ARP040101128 A AR P040101128A AR P040101128 A ARP040101128 A AR P040101128A AR 043963 A1 AR043963 A1 AR 043963A1
- Authority
- AR
- Argentina
- Prior art keywords
- isomers
- compounds
- derivatives
- bencimidazol
- gaba
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta presente se refiere a derivados del bencimidazol, composiciones farmacéuticas que contienen estos compuestos y métodos de tratamiento con los mismos. Los compuestos de la presente son de utilidad en el tratamiento de enfermedades y trastornos del sistema nervioso central, los cuales responden a la modulación del complejo del receptor de GABAA, y en particular, para combatir la ansiedad y enfermedades relacionadas. Reivindicación 1: Un compuesto de fórmula general (1), o un N-óxido del mismo, o cualquiera de sus isómeros o cualquier mezcla de sus isómeros, o una sal del mismo aceptable desde el punto de vista farmacéutico, en el cual: R representa hidroxialquilo, alcoxialquilo, cicloalcoxialquilo, cicloalquilalcoxialquilo, alqueniloxialquilo o alquiniloxialquilo; y R' representa un anillo heterocíclico de cinco miembros; el cual puede estar sustituido en forma opcional con uno o más sustituyentes independientes seleccionados entre el grupo que consiste de halo, hidroxi, amino, alquilamino, aminoalquilo, ciano, nitro, trifluorometilo, trifluorometoxi, alcoxi, cicloalcoxi, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo y alquinilo.This refers to benzimidazole derivatives, pharmaceutical compositions containing these compounds and methods of treatment therewith. The compounds herein are useful in the treatment of diseases and disorders of the central nervous system, which respond to the modulation of the GABAA receptor complex, and in particular, to combat anxiety and related diseases. Claim 1: A compound of the general formula (1), or an N-oxide thereof, or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof, in which: R represents hydroxyalkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkenyloxyalkyl or alkynyloxyalkyl; and R 'represents a five-membered heterocyclic ring; which may be optionally substituted with one or more independent substituents selected from the group consisting of halo, hydroxy, amino, alkylamino, aminoalkyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300509 | 2003-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043963A1 true AR043963A1 (en) | 2005-08-17 |
Family
ID=36703994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101128A AR043963A1 (en) | 2003-04-03 | 2004-04-02 | DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN1759112A (en) |
AR (1) | AR043963A1 (en) |
TW (1) | TW200510390A (en) |
-
2004
- 2004-03-31 TW TW093108831A patent/TW200510390A/en unknown
- 2004-04-01 CN CNA2004800064309A patent/CN1759112A/en active Pending
- 2004-04-02 AR ARP040101128A patent/AR043963A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200510390A (en) | 2005-03-16 |
CN1759112A (en) | 2006-04-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20190656A1 (en) | TIAZOLO-PYRIDINE COMPOUNDS REPLACED AS INHIBITORS OF MALT1 | |
CO5630004A2 (en) | NEW DERIVATIVES OF 8-AZA-BICYCLE [3,2,1] OCTANO AND ITS USE AS INHIBITORS OF THE RE-CAPTURE OF MONOAMINIC NEUROTRANSMITTERS | |
AR043434A1 (en) | PIPERIZACINE DERIVATIVES ACILATED AS AGELISTS OF THE RECEIVER OF MELANOCORTINA-4. PHARMACEUTICAL COMPOSITIONS AND USES | |
PE20220931A1 (en) | PYRAZOLO[3,4-B]PYRAZINE-TYPE SHP2 PHOSPHATASE INHIBITORS | |
AR060084A1 (en) | USEFUL BENZIMIDAZOL DERIVATIVES AS MODULATORS OF THE GABA-A RECEIVER COMPLEX | |
AR047531A1 (en) | DERIVATIVES 1H-TIENO (2,3-C) PIRAZOL USEFUL AS QUINASE INHIBITORS | |
AR059064A1 (en) | TIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES IN THE TREATMENT OF DISEASES MEDIATED BY PROTEIN KINASE B (PKB), SUCH AS CANCER. | |
PE20060531A1 (en) | DERIVATIVES OF PYRIDAZIN-3- (2H) -ONE AS INHIBITORS OF PHOSPHODIESTERASE 4 | |
AR049276A1 (en) | OPIOOD CARBOXAMID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
PA8675701A1 (en) | NEW DERIVATIVES OF FLUORENE, COMPOSITIONS THAT CONTAIN THEM AND ITS USE | |
ECSP055536A (en) | DERIVATIVES OF 1-HETEROCICLILALQUIL-3-SULFONILINDOL OR INDAZOL AS LIGANDS OF 5-HYDROXITRIPTAMINE-6 | |
AR079327A1 (en) | DERIVATIVES OF 2-AMINO-5,5-DIFLUOR -5,6-DIHIDRO-4H- (1,3) OXAZIN-4-IL) PHENYL) -AMIDA | |
ECSP056115A (en) | ANTAGONISTS OF A2A-2-ALQUINIL- AND 2-ALQUENIL-PIRAZOLO- [4,3-e] -1,2,4-TRIAZOLO- [1,5-c] -PIRIMIDINE ADENOSINE RECEPTOR | |
UY26048A1 (en) | DERIVATIVES OF PIRIDOPIRANOACEPINAS, ITS PREPARATION AND ITS THERAPEUTIC APPLICATION | |
PE20030922A1 (en) | PYRIDINE AND QUINOLINE DERIVATIVES | |
CR7643A (en) | DERIVATIVES OF 1-HETEROCICLIALQUIL -3-SULFONYLAZAINDOL OR AZAINDAZOL AS LIGANDS OF 5-HYDROXITRIPTAMINE-6 | |
UY28150A1 (en) | THERAPEUTIC AGENTS | |
GB0507601D0 (en) | Compounds | |
CO5690551A2 (en) | TETRAZOL DERIVATIVES AND METHODS FOR TREATMENT WITH THE SAME DISORDERS RELATED TO METABOLISM | |
ECSP045473A (en) | DERIVATIVES OF 1- (AMINOALQUIL) -3-SULFONYLINDOL AND 1-AMINOALQUIL-3-SULFONYLINDAZOL AS 5-HYDROXYTHYRIPTAMINE-6 LIGANDS | |
AR102213A1 (en) | INHIBITORS OF HEPARAN SULPHATE BIOSYNTHESIS FOR THE TREATMENT OF DISEASES | |
AR050711A1 (en) | ARILSULFONYLESTILBEN DERIVATIVES FOR THE TREATMENT AND / OR PREVENTION OF AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM | |
AR075383A1 (en) | DERIVATIVES OF TRIAZOLO [4,3-B] PIRIDAZINA | |
PE20211246A1 (en) | CYCLING COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS | |
AR073043A1 (en) | COMPOUNDS OF POLYSUSTITUTED AZETIDINS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, METHOD OF PREPARATION AND USE OF THE SAME IN THE TREATMENT OF RESPIRATORY, METABOLIC DISEASES AND OF THE CENTRAL NERVOUS SYSTEM, AMONG OTHERS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |