AR043963A1 - DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO - Google Patents

DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO

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Publication number
AR043963A1
AR043963A1 ARP040101128A ARP040101128A AR043963A1 AR 043963 A1 AR043963 A1 AR 043963A1 AR P040101128 A ARP040101128 A AR P040101128A AR P040101128 A ARP040101128 A AR P040101128A AR 043963 A1 AR043963 A1 AR 043963A1
Authority
AR
Argentina
Prior art keywords
isomers
compounds
derivatives
bencimidazol
gaba
Prior art date
Application number
ARP040101128A
Other languages
Spanish (es)
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Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of AR043963A1 publication Critical patent/AR043963A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta presente se refiere a derivados del bencimidazol, composiciones farmacéuticas que contienen estos compuestos y métodos de tratamiento con los mismos. Los compuestos de la presente son de utilidad en el tratamiento de enfermedades y trastornos del sistema nervioso central, los cuales responden a la modulación del complejo del receptor de GABAA, y en particular, para combatir la ansiedad y enfermedades relacionadas. Reivindicación 1: Un compuesto de fórmula general (1), o un N-óxido del mismo, o cualquiera de sus isómeros o cualquier mezcla de sus isómeros, o una sal del mismo aceptable desde el punto de vista farmacéutico, en el cual: R representa hidroxialquilo, alcoxialquilo, cicloalcoxialquilo, cicloalquilalcoxialquilo, alqueniloxialquilo o alquiniloxialquilo; y R' representa un anillo heterocíclico de cinco miembros; el cual puede estar sustituido en forma opcional con uno o más sustituyentes independientes seleccionados entre el grupo que consiste de halo, hidroxi, amino, alquilamino, aminoalquilo, ciano, nitro, trifluorometilo, trifluorometoxi, alcoxi, cicloalcoxi, alquilo, cicloalquilo, cicloalquilalquilo, alquenilo y alquinilo.This refers to benzimidazole derivatives, pharmaceutical compositions containing these compounds and methods of treatment therewith. The compounds herein are useful in the treatment of diseases and disorders of the central nervous system, which respond to the modulation of the GABAA receptor complex, and in particular, to combat anxiety and related diseases. Claim 1: A compound of the general formula (1), or an N-oxide thereof, or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof, in which: R represents hydroxyalkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkenyloxyalkyl or alkynyloxyalkyl; and R 'represents a five-membered heterocyclic ring; which may be optionally substituted with one or more independent substituents selected from the group consisting of halo, hydroxy, amino, alkylamino, aminoalkyl, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl.

ARP040101128A 2003-04-03 2004-04-02 DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO AR043963A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200300509 2003-04-03

Publications (1)

Publication Number Publication Date
AR043963A1 true AR043963A1 (en) 2005-08-17

Family

ID=36703994

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101128A AR043963A1 (en) 2003-04-03 2004-04-02 DERIVATIVES OF BENCIMIDAZOL AND ITS USE TO MODULATE THE GABA RECEIVER COMPLEX TO

Country Status (3)

Country Link
CN (1) CN1759112A (en)
AR (1) AR043963A1 (en)
TW (1) TW200510390A (en)

Also Published As

Publication number Publication date
TW200510390A (en) 2005-03-16
CN1759112A (en) 2006-04-12

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