GB9916882D0
(en)
*
|
1999-07-19 |
1999-09-22 |
Pharmacia & Upjohn Spa |
Antitumor synergistic composition
|
EP1496897A4
(en)
|
2002-04-12 |
2006-05-10 |
Merck & Co Inc |
Tyrosine kinase inhibitors
|
ATE360015T1
(en)
|
2002-07-31 |
2007-05-15 |
Critical Outcome Technologies |
PROTEIN TYROSINE KINASE INHIBITORS
|
EP1551824B1
(en)
|
2002-10-09 |
2007-12-12 |
Critical Outcome Technologies, Inc. |
Protein tyrosine kinase inhibitors
|
DE10354060A1
(en)
|
2003-11-19 |
2005-06-02 |
Merck Patent Gmbh |
pyrrole
|
DE10355904A1
(en)
|
2003-11-29 |
2005-06-30 |
Merck Patent Gmbh |
Solid forms of anti-EGFR antibodies
|
CN100438913C
(en)
*
|
2004-11-22 |
2008-12-03 |
山东蓝金生物工程有限公司 |
Anti-cancer medicine composition
|
CN100402091C
(en)
*
|
2005-02-03 |
2008-07-16 |
山东蓝金生物工程有限公司 |
Anticarcinogen composition
|
CN100350974C
(en)
*
|
2005-02-03 |
2007-11-28 |
山东蓝金生物工程有限公司 |
Anticarcinogen composition
|
DE102005016634A1
(en)
|
2005-04-12 |
2006-10-19 |
Merck Patent Gmbh |
Novel aza heterocycles as kinase inhibitors
|
US8859581B2
(en)
|
2005-04-25 |
2014-10-14 |
Merck Patent Gmbh |
Azaheterocyclic compounds as kinase inhibitors
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
DE102005061840A1
(en)
|
2005-12-23 |
2007-06-28 |
Merck Patent Gmbh |
New polyaza-benzo-azulene compounds are transforming growth factor-beta receptor kinase inhibitors used for treating e.g. cancer, HIV infection and Alzheimer's disease
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
EP2946778A1
(en)
|
2006-09-22 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
AU2007340129B2
(en)
|
2006-12-26 |
2012-02-02 |
Pharmacyclics Llc |
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
|
EP2109608B1
(en)
|
2007-01-10 |
2011-03-23 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
US8138191B2
(en)
|
2007-01-11 |
2012-03-20 |
Critical Outcome Technologies Inc. |
Inhibitor compounds and cancer treatment methods
|
DE102007008419A1
(en)
|
2007-02-21 |
2008-08-28 |
Merck Patent Gmbh |
4- (pyrrolopyridinyl) -pyrimidinyl-2-amine derivatives
|
EA019951B1
(en)
|
2007-03-01 |
2014-07-30 |
Новартис Аг |
Pim kinase inhibitors and methods of their use
|
DE102007013855A1
(en)
|
2007-03-20 |
2008-09-25 |
Merck Patent Gmbh |
Substituted tetrahydroquinolines
|
DE102007013854A1
(en)
|
2007-03-20 |
2008-09-25 |
Merck Patent Gmbh |
Tetrahydroquinolines
|
DE102007013856A1
(en)
|
2007-03-20 |
2008-09-25 |
Merck Patent Gmbh |
Substituted tetrahydropyrroloquinolines
|
KR20100017866A
(en)
|
2007-05-21 |
2010-02-16 |
노파르티스 아게 |
Csf-1r inhibitors, compositions, and methods of use
|
DE102007028515A1
(en)
|
2007-06-21 |
2008-12-24 |
Merck Patent Gmbh |
6- (pyrrolopyridinyl) -pyrimidinyl-2-amine derivatives
|
EP3103791B1
(en)
|
2007-06-27 |
2018-01-31 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
DE102007047738A1
(en)
|
2007-10-05 |
2009-04-09 |
Merck Patent Gmbh |
imidazole derivatives
|
DE102007047735A1
(en)
|
2007-10-05 |
2009-04-09 |
Merck Patent Gmbh |
thiazole
|
DE102007047737A1
(en)
|
2007-10-05 |
2009-04-30 |
Merck Patent Gmbh |
Piperidine and piperazine derivatives
|
DE102007049451A1
(en)
|
2007-10-16 |
2009-04-23 |
Merck Patent Gmbh |
5-Cyano-thienopyridine
|
AU2008336249B2
(en)
|
2007-12-10 |
2015-01-29 |
The University Of Queensland |
Treatment and prophylaxis
|
WO2009079797A1
(en)
|
2007-12-26 |
2009-07-02 |
Critical Outcome Technologies, Inc. |
Compounds and method for treatment of cancer
|
DE102008005493A1
(en)
|
2008-01-22 |
2009-07-23 |
Merck Patent Gmbh |
4- (Pyrrolo [2,3-c] pyridines-3-yl) -pyrimidin-2-yl-amine derivatives
|
DE102008017853A1
(en)
|
2008-04-09 |
2009-10-15 |
Merck Patent Gmbh |
thienopyrimidines
|
ES2575873T3
(en)
|
2008-04-15 |
2016-07-01 |
Pharmacyclics Llc |
Selective histone deacetylase inhibitors
|
DE102008025751A1
(en)
|
2008-05-29 |
2009-12-03 |
Merck Patent Gmbh |
New 4-(1H-pyrrolo(2,3-b)pyridin-3-yl)-pyridin-2-yl-amine derivatives are serine kinase modulators, useful to treat solid tumors, tumor growth, tumor metastasis, AIDS, occlusive neointimal lesions, arteriosclerosis, coronary artery disease
|
DE102008027574A1
(en)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
New pyrrolidine derivatives as MetAP-2 inhibitors
|
DE102008031517A1
(en)
|
2008-07-03 |
2010-01-07 |
Merck Patent Gmbh |
Pyrrolopyridinyl-pyrimidin-2-yl-amine derivatives
|
DE102008059578A1
(en)
|
2008-11-28 |
2010-06-10 |
Merck Patent Gmbh |
Benzo-naphthyridine compounds
|
DE102009005193A1
(en)
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Novel heterocyclic compounds as MetAP-2 inhibitors
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
KR20120027192A
(en)
|
2009-04-02 |
2012-03-21 |
메르크 파텐트 게엠베하 |
Heterocyclic compounds as autotaxin inhibitors
|
MX2011010218A
(en)
|
2009-04-02 |
2011-10-10 |
Merck Patent Gmbh |
Autotaxin inhibitors.
|
EP2626072B1
(en)
|
2009-04-02 |
2019-12-04 |
Merck Patent GmbH |
Piperidine and piperazine derivatives as autotaxin inhibitors
|
DE102009019962A1
(en)
|
2009-05-05 |
2010-11-11 |
Merck Patent Gmbh |
3 - ([1,2,3] triazol-4-yl) -pyrrolo [2,3-b] pyridine
|
WO2010144909A1
(en)
|
2009-06-12 |
2010-12-16 |
Novartis Ag |
Fused heterocyclic compounds and their uses
|
DE102009033208A1
(en)
|
2009-07-15 |
2011-01-20 |
Merck Patent Gmbh |
aminopyridine derivatives
|
DE102009033392A1
(en)
|
2009-07-16 |
2011-01-20 |
Merck Patent Gmbh |
Heterocyclic compounds as autotaxine inhibitors II
|
JP2013502441A
(en)
|
2009-08-26 |
2013-01-24 |
アルバータ・ヘルス・サービシーズ |
Novel colchicine derivatives, methods and uses thereof
|
DE102009049211A1
(en)
|
2009-10-13 |
2011-04-28 |
Merck Patent Gmbh |
sulfoxides
|
CN104945382B
(en)
|
2009-10-14 |
2020-02-07 |
默沙东公司 |
Substituted piperidines that increase p53 activity and uses thereof
|
WO2011054433A1
(en)
|
2009-11-07 |
2011-05-12 |
Merck Patent Gmbh |
Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors
|
DE102009060175A1
(en)
|
2009-12-23 |
2011-06-30 |
Merck Patent GmbH, 64293 |
Pyrrolo [2,3-d] pyrazine-7-yl-pyrimidine compounds
|
DE102009060174A1
(en)
|
2009-12-23 |
2011-06-30 |
Merck Patent GmbH, 64293 |
Pyrrolopyridinyl-pyrimidin-2-yl-amine derivatives
|
EP2519517B1
(en)
|
2009-12-29 |
2015-03-25 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
EA201290919A1
(en)
|
2010-03-16 |
2013-03-29 |
Дана-Фарбер Кэнсер Инститьют, Инк. |
INDASOLIC COMPOUNDS AND THEIR APPLICATION
|
AU2011232058B2
(en)
|
2010-03-26 |
2016-09-08 |
Merck Patent Gmbh |
Benzonaphthyridinamines as autotaxin inhibitors
|
WO2011120153A1
(en)
|
2010-04-01 |
2011-10-06 |
Critical Outcome Technologies Inc. |
Compounds and method for treatment of hiv
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
BR112012033241A2
(en)
|
2010-06-28 |
2016-11-16 |
Merck Patent Gmbh |
[1,8] 2,4-Diaryl-substituted naphthyridines as cancer kinase inhibitors
|
SG186871A1
(en)
|
2010-07-05 |
2013-02-28 |
Merck Patent Gmbh |
Bipyridyl derivatives useful for the treatment of kinase - induced diseases
|
JP6043285B2
(en)
|
2010-08-02 |
2016-12-14 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
RNA interference-mediated inhibition of catenin (cadherin-binding protein) β1 (CTNNB1) gene expression using small interfering nucleic acids (siNA)
|
CN108676800B
(en)
|
2010-08-17 |
2022-11-11 |
瑟纳治疗公司 |
RNA interference-mediated suppression of Hepatitis B Virus (HBV) gene expression using short interfering nucleic acids (siNA)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
EP2613782B1
(en)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
CN103189378B
(en)
|
2010-09-02 |
2016-03-02 |
默克专利股份公司 |
As the Pyrazolopyridine ketone derivatives of LPA receptor antagonist
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
DE102010048374A1
(en)
|
2010-10-13 |
2012-04-19 |
Merck Patent Gmbh |
Pyrrolidinones as MetAP-2 inhibitors
|
ES2663009T3
(en)
|
2010-10-29 |
2018-04-10 |
Sirna Therapeutics, Inc. |
Inhibition of RNA-mediated gene expression using short interference nucleic acids (ANic)
|
DE102010049877A1
(en)
|
2010-11-01 |
2012-05-03 |
Merck Patent Gmbh |
7 - ((1,2,3) triazol-4-yl) -pyrrolo (2,3) pyrazine derivatives
|
DE102010050558A1
(en)
|
2010-11-05 |
2012-05-10 |
Merck Patent Gmbh |
1H-pyrrolo [2,3-b] pyridine
|
DE102010053347A1
(en)
|
2010-12-03 |
2012-06-06 |
Merck Patent Gmbh |
3-hetaryl-substituted pyrrolo [2,3-b] pyridine-derivative as PDK1 inhibitors
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
DE102011008352A1
(en)
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5 - ([1,2,3] triazol-4-yl) -7H-pyrrolo [2,3-d] pyrimidine derivatives
|
DE102011009961A1
(en)
|
2011-02-01 |
2012-08-02 |
Merck Patent Gmbh |
7-azaindole derivatives
|
EP2683715B1
(en)
|
2011-03-09 |
2015-04-15 |
Merck Patent GmbH |
Pyrido[2,3-b]pyrazine derivatives and their therapeutical uses
|
CN103732592A
(en)
|
2011-04-21 |
2014-04-16 |
默沙东公司 |
Insulin-like growth factor-1 receptor inhibitors
|
US9273029B2
(en)
|
2011-05-23 |
2016-03-01 |
Merck Patent Gmbh |
Pyridine-and pyrazine derivatives
|
CA2875025C
(en)
|
2011-05-31 |
2021-08-03 |
Newgen Therapeutics, Inc. |
Tricyclic inhibitors of poly(adp-ribose)polymerase
|
DE102011105469A1
(en)
|
2011-06-24 |
2012-12-27 |
Merck Patent Gmbh |
7-azaindole derivatives
|
WO2013022519A1
(en)
|
2011-08-10 |
2013-02-14 |
Merck Patent Gmbh |
Pyrido-pyrimidine derivatives
|
DE102011112978A1
(en)
|
2011-09-09 |
2013-03-14 |
Merck Patent Gmbh |
benzonitrile derivatives
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
JP6106685B2
(en)
|
2011-11-17 |
2017-04-05 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
Inhibitors of C-JUN-N-terminal kinase (JNK)
|
DE102011119127A1
(en)
|
2011-11-22 |
2013-05-23 |
Merck Patent Gmbh |
3-Cyanaryl-1H-pyrrolo [2,3-b] pyridine derivatives
|
KR20140120371A
(en)
|
2012-02-09 |
2014-10-13 |
메르크 파텐트 게엠베하 |
Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors
|
DE102012006884A1
(en)
|
2012-04-04 |
2013-10-10 |
Merck Patent Gmbh |
Cyclic amides as MetAP-2 inhibitors
|
EP3358013B1
(en)
|
2012-05-02 |
2020-06-24 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
CN105050598B
(en)
|
2012-09-28 |
2018-04-27 |
默沙东公司 |
New compound as ERK inhibitor
|
DE102012019369A1
(en)
|
2012-10-02 |
2014-04-03 |
Merck Patent Gmbh |
7-Azaindolderivat
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
CA2892361A1
(en)
|
2012-11-28 |
2014-06-05 |
Merck Sharp & Dohme Corp. |
Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
|
AU2013361694B2
(en)
|
2012-12-20 |
2017-10-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as HDM2 inhibitors
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
NO3003315T3
(en)
|
2013-06-06 |
2018-06-16 |
|
|
EP3041938A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015034928A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2015058126A1
(en)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
AU2014337044A1
(en)
|
2013-10-18 |
2016-05-05 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
US10017477B2
(en)
|
2014-04-23 |
2018-07-10 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
WO2015164604A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
JO3589B1
(en)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
Protein kinase c inhibitors and methods of their use
|
PT3227310T
(en)
|
2014-12-03 |
2019-11-06 |
Glycomimetics Inc |
Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
US10550121B2
(en)
|
2015-03-27 |
2020-02-04 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
CA3026154A1
(en)
|
2015-06-03 |
2016-12-08 |
The University Of Queensland |
Mobilizing agents and uses therefor
|
CA2986441A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
CA2996978A1
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
US11291678B2
(en)
|
2016-03-02 |
2022-04-05 |
Glycomimetics, Inc |
Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
|
US11066396B2
(en)
|
2016-06-23 |
2021-07-20 |
Merck Sharp & Dohme Corp. |
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
|
EP3497131B1
(en)
|
2016-08-08 |
2022-03-09 |
GlycoMimetics, Inc. |
Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
|
JOP20190055A1
(en)
|
2016-09-26 |
2019-03-24 |
Merck Sharp & Dohme |
Anti-cd27 antibodies
|
KR102653723B1
(en)
|
2016-10-07 |
2024-04-01 |
글리코미메틱스, 인크. |
Highly potent multimeric e-selectin antagonists
|
EP3525785A4
(en)
|
2016-10-12 |
2020-03-25 |
Merck Sharp & Dohme Corp. |
Kdm5 inhibitors
|
US11197877B2
(en)
|
2017-03-15 |
2021-12-14 |
Glycomimetics. Inc. |
Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
|
AU2018252546A1
(en)
|
2017-04-13 |
2019-10-10 |
Sairopa B.V. |
Anti-SIRPα antibodies
|
KR20200041354A
(en)
|
2017-08-16 |
2020-04-21 |
메르크 파텐트 게엠베하 |
Stable lyophilisate containing 5,10-methylene- (6R) -tetrahydrofolic acid and dicarboxylic acid
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
US11712446B2
(en)
|
2017-11-30 |
2023-08-01 |
Glycomimetics, Inc. |
Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
|
CA3085356A1
(en)
|
2017-12-29 |
2019-07-04 |
Glycomimetics, Inc. |
Heterobifunctional inhibitors of e-selectin and galectin-3
|
WO2019148412A1
(en)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anti-pd-1/lag3 bispecific antibodies
|
BR112020018184A2
(en)
|
2018-03-05 |
2021-02-02 |
Glycomimetics, Inc. |
compound uses
|
US11874276B2
(en)
|
2018-04-05 |
2024-01-16 |
Dana-Farber Cancer Institute, Inc. |
STING levels as a biomarker for cancer immunotherapy
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
US11981701B2
(en)
|
2018-08-07 |
2024-05-14 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
US11845771B2
(en)
|
2018-12-27 |
2023-12-19 |
Glycomimetics, Inc. |
Heterobifunctional inhibitors of E-selectin and galectin-3
|
US20220305048A1
(en)
|
2019-08-26 |
2022-09-29 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
CN115087638B
(en)
|
2019-12-17 |
2023-11-24 |
默沙东公司 |
PRMT5 inhibitors
|