AR042694A1 - IMIDAZOL AND TRIAZOL DERIVATIVES COX-1 INHIBITORS, SYNTHESIS METHOD AND PHARMACEUTICAL COMPOSITIONS - Google Patents

IMIDAZOL AND TRIAZOL DERIVATIVES COX-1 INHIBITORS, SYNTHESIS METHOD AND PHARMACEUTICAL COMPOSITIONS

Info

Publication number
AR042694A1
AR042694A1 ARP030104881A ARP030104881A AR042694A1 AR 042694 A1 AR042694 A1 AR 042694A1 AR P030104881 A ARP030104881 A AR P030104881A AR P030104881 A ARP030104881 A AR P030104881A AR 042694 A1 AR042694 A1 AR 042694A1
Authority
AR
Argentina
Prior art keywords
cyano
imidazol
cox
inhibitors
pharmaceutical compositions
Prior art date
Application number
ARP030104881A
Other languages
Spanish (es)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2002953602A external-priority patent/AU2002953602A0/en
Priority claimed from AU2003901804A external-priority patent/AU2003901804A0/en
Priority claimed from AU2003903928A external-priority patent/AU2003903928A0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of AR042694A1 publication Critical patent/AR042694A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto de fórmula (1), en la cual R1 es alquilo inferior el cual está sustituido, en forma opcional, por sustituyente(s) adecuado(s); cicloalquilo inferior; alquinilo inferior; ciano; acilo; grupo heterocíclico, etc.; R2 es alquilo inferior, alcoxi inferior, ciano o 1H-pirrol-1-ilo; R3 es alquileno inferior o alquinileno inferior; R4 es hidroxi, hidroxi protegido, amino, amino protegido; acilamino, acilo, ciano o un grupo heterocíclico; X es O, S, SO o SO2; Y es CH o N; Z es CH o N; W es O, S, SO o SO2; m es 0 ó 1; n es 0 ó 1; y circulo A es triazol o imidazol; o sales del mismo, que son útiles como medicamentos para el tratamiento de afecciones inflamatorias, dolores, enfermedades del colágeno, enfermedades autoinmunes, trombosis, cáncer o enfermedades neurodegenerativas.A compound of formula (1), in which R 1 is lower alkyl which is optionally substituted by suitable substituent (s); lower cycloalkyl; lower alkynyl; cyano; acyl; heterocyclic group, etc .; R2 is lower alkyl, lower alkoxy, cyano or 1H-pyrrole-1-yl; R3 is lower alkylene or lower alkynylene; R4 is hydroxy, protected hydroxy, amino, protected amino; acylamino, acyl, cyano or a heterocyclic group; X is O, S, SO or SO2; Y is CH or N; Z is CH or N; W is O, S, SO or SO2; m is 0 or 1; n is 0 or 1; and circle A is triazole or imidazole; or salts thereof, which are useful as medications for the treatment of inflammatory conditions, pains, collagen diseases, autoimmune diseases, thrombosis, cancer or neurodegenerative diseases.

ARP030104881A 2002-12-30 2003-12-30 IMIDAZOL AND TRIAZOL DERIVATIVES COX-1 INHIBITORS, SYNTHESIS METHOD AND PHARMACEUTICAL COMPOSITIONS AR042694A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2002953602A AU2002953602A0 (en) 2002-12-30 2002-12-30 New compounds
AU2003901804A AU2003901804A0 (en) 2003-04-15 2003-04-15 New compounds
AU2003903928A AU2003903928A0 (en) 2003-07-28 2003-07-28 New compounds

Publications (1)

Publication Number Publication Date
AR042694A1 true AR042694A1 (en) 2005-06-29

Family

ID=32718317

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104881A AR042694A1 (en) 2002-12-30 2003-12-30 IMIDAZOL AND TRIAZOL DERIVATIVES COX-1 INHIBITORS, SYNTHESIS METHOD AND PHARMACEUTICAL COMPOSITIONS

Country Status (3)

Country Link
AR (1) AR042694A1 (en)
TW (1) TW200424197A (en)
WO (1) WO2004060367A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094407A1 (en) * 2003-04-21 2004-11-04 Daiichi Pharmaceutical Co. Ltd. Five-membered heterocyclic derivative
JP2006525320A (en) * 2003-05-08 2006-11-09 アステラス製薬株式会社 COX inhibitor
CA2560417C (en) 2004-04-03 2011-04-19 Astrazeneca Ab 1,2-diarylimidazole-4-carboxamide derivatives
JPWO2006043594A1 (en) * 2004-10-19 2008-05-22 第一製薬株式会社 1,5-diheterocyclic-1H-triazole derivative
EP2368881A1 (en) * 2005-01-10 2011-09-28 University of Connecticut Heteropyrazole analogs acting on cannabinoid receptors
AT502258B1 (en) * 2005-07-22 2007-09-15 Univ Wien COX-I-INHIBITOR COMPOUNDS
JPWO2008029912A1 (en) 2006-09-07 2010-01-21 国立大学法人 岡山大学 Compound having benzamide as skeleton having cyclooxygenase 1 (COX-1) selective inhibitory activity
PE20110843A1 (en) 2008-09-22 2011-12-08 Cayman Chem Co DERIVATIVES OF 5- (1H-IMIDAZOL-5-IL) -2-PHENYLPYRIMIDINE, AS INHIBITORS OF PROSTAGLANDIN D HEMATOPOYETIC SYNTHASE
BR112015003393A2 (en) * 2012-08-16 2017-07-04 Janssen Pharmaceutica Nv substituted pyrazoles as n-type calcium channel blockers
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
CN104415172A (en) * 2013-09-09 2015-03-18 廖国建 Medicament for treating scapulohumeral periarthritis
DK3359528T3 (en) 2015-10-07 2022-03-07 Mitobridge Inc Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
KR102430906B1 (en) 2016-04-13 2022-08-10 미토브리지, 인크. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
EA039771B1 (en) * 2016-06-20 2022-03-11 Митобридж, Инк. Ppar agonists, compounds, pharmaceutical compositions and methods of use thereof
CA3125847A1 (en) 2020-07-27 2022-01-27 Makscientific, Llc Process for making biologically active compounds and intermediates thereof
WO2024009283A1 (en) * 2022-07-07 2024-01-11 University Of Southern California At2 antagonists for non-addictive pain relief

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193265B1 (en) * 1996-01-26 2006-11-29 G.D. Searle LLC A process for the preparation of 4-¬2-(aryl or heterocyclo)-1H-imidazol-1-yl|benzenesulfonamides
DE69739003D1 (en) * 1996-04-12 2008-10-30 Searle Llc Substituted benzenesulfonamide derivatives as drug precursors of COX-2 inhibitors
EP1099695A1 (en) * 1999-11-09 2001-05-16 Laboratoire Theramex S.A. 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
AUPR878201A0 (en) * 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds

Also Published As

Publication number Publication date
WO2004060367A1 (en) 2004-07-22
TW200424197A (en) 2004-11-16

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