AR041652A1 - BENZOXAZOLES OR OXAZOLOPIRIDIN COMPOUNDS, A PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
BENZOXAZOLES OR OXAZOLOPIRIDIN COMPOUNDS, A PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- AR041652A1 AR041652A1 ARP030103787A ARP030103787A AR041652A1 AR 041652 A1 AR041652 A1 AR 041652A1 AR P030103787 A ARP030103787 A AR P030103787A AR P030103787 A ARP030103787 A AR P030103787A AR 041652 A1 AR041652 A1 AR 041652A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- atom
- alkyl
- represent
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Compuestos de la fórmula (1) caracterizado porque: A representa un fenilo no sustituido o sustituido, o una piridina no sustituida o sustituida; X representa un átomo de O o de S; Y representa un átomo de O o de S; R1 y R2, idénticos o diferentes, representan cada uno un grupo COOR5 donde R5 representa un átomo de H o un grupo alquilo, alquenilo, alquinilo, cicloalquilo o cicloalquilalquilo; R3 y R4 representan cada uno un átomo de H o forman juntos, cuando están en dos átomos de C adyacentes, un grupo mono o policíclico fusionado, donde * por "alquilo" debe entenderse un grupo alquilo C1-6 lineal o ramificado, * por "alquenilo" debe entenderse un grupo alquenilo C2-6 lineal o ramificado, *por "alquinilo" debe entenderse un grupo alquinilo C2-6 lineal o ramificado, * por "fenilo sustituido" y "piridina sustituida" debe entenderse un grupo fenilo o piridina sustituida por 1 a 3 grupos elegidos entre alquilo, alcoxi, hidroxi, COOR (donde R representa un átomo de H o un grupo alquilo), formilo, amino, alquilamino, dialquilamino, trihalógenoalquilo o átomos de halógeno; * por "grupo mono o policíclico fusionado debe entenderse todo grupo mono o policíclico que contiene 5 a 10 eslabones, que puede contener una o varias instauraciones y que puede contener de 1 a 3 heteroátomos elegidos entre O, S y N, el grupo mono o policíclico fusionado así definido puede ser sustituido por 1 a 3 grupos elegidos entre alquilo, alcoxi, hidroxi, COOR (donde R representa un átomo de H o un grupo alquilo); formilo, amino, alquilamino, dialquilamino, CONRR´ (donde R y R´, que pueden ser iguales o diferente, representan un átomo de H o un grupo alquilo), NRCOOR´(donde R y R´, que pueden ser iguales o diferentes, representan un átomo de H o un grupo alquilo), trihalógenoalquilo, espiro-alquilenodioxi , y átomos de halógenos, y se conviene que: A no puede representar un grupo como se muestra en fórmula (2) donde R representa un átomo de H o un grupo alquilo, sus enantiómeros y diastereoisómeros, como así también sus sales de adición a un ácido o una base farmacéuticamente aceptable.Claim 1: Compounds of the formula (1) characterized in that: A represents an unsubstituted or substituted phenyl, or an unsubstituted or substituted pyridine; X represents an atom of O or S; Y represents an atom of O or S; R1 and R2, identical or different, each represent a COOR5 group where R5 represents an H atom or an alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl group; R3 and R4 each represent an atom of H or together, when they are in two adjacent C atoms, a fused mono or polycyclic group, where * by "alkyl" should be understood as a linear or branched C1-6 alkyl group, * by "alkenyl" means a linear or branched C2-6 alkenyl group, * by "alkynyl" means a linear or branched C2-6 alkynyl group, * by "substituted phenyl" and "substituted pyridine" means a phenyl or pyridine group substituted by 1 to 3 groups selected from alkyl, alkoxy, hydroxy, COOR (where R represents an H atom or an alkyl group), formyl, amino, alkylamino, dialkylamino, trihaloalkyl or halogen atoms; * "fused mono or polycyclic group should be understood as any mono or polycyclic group that contains 5 to 10 links, which may contain one or more instances and that may contain 1 to 3 heteroatoms chosen from O, S and N, the mono group or Fused polycyclic thus defined can be substituted by 1 to 3 groups chosen from alkyl, alkoxy, hydroxy, COOR (where R represents an H atom or an alkyl group); formyl, amino, alkylamino, dialkylamino, CONRR '(where R and R ´, which can be the same or different, represent an atom of H or an alkyl group), NRCOOR´ (where R and R´, which can be the same or different, represent an atom of H or an alkyl group), trihaloalkyl, spiro -alkylenedioxy, and halogen atoms, and it is agreed that: A cannot represent a group as shown in formula (2) where R represents an H atom or an alkyl group, its enantiomers and diastereoisomers, as well as its salts of addition to an acid or a base and pharmaceutically acceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212962A FR2845998A1 (en) | 2002-10-18 | 2002-10-18 | New N-phenyl-benzoxazole or -benzthiazole derivatives, useful for treating e.g. diabetes and cancers, are modulators of the peroxisome-activated receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041652A1 true AR041652A1 (en) | 2005-05-26 |
Family
ID=32050500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103787A AR041652A1 (en) | 2002-10-18 | 2003-10-17 | BENZOXAZOLES OR OXAZOLOPIRIDIN COMPOUNDS, A PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR041652A1 (en) |
| AU (1) | AU2003301530A1 (en) |
| FR (1) | FR2845998A1 (en) |
| WO (1) | WO2004037829A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | Mif modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| BR112022011283A2 (en) * | 2019-12-10 | 2022-09-06 | Shanghai Zhimeng Biopharma Inc | COMPOUND THAT HAS A NEUROPROTECTIVE EFFECT, METHOD OF PREPARATION FOR IT AND USE OF IT |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2804431A1 (en) * | 2000-02-02 | 2001-08-03 | Adir | NEW HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
2002
- 2002-10-18 FR FR0212962A patent/FR2845998A1/en active Pending
-
2003
- 2003-10-17 AR ARP030103787A patent/AR041652A1/en unknown
- 2003-10-17 WO PCT/FR2003/003067 patent/WO2004037829A1/en not_active Application Discontinuation
- 2003-10-17 AU AU2003301530A patent/AU2003301530A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004037829A1 (en) | 2004-05-06 |
| AU2003301530A1 (en) | 2004-05-13 |
| FR2845998A1 (en) | 2004-04-23 |
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|---|---|---|---|
| FB | Suspension of granting procedure |