AR041606A1 - ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER - Google Patents

ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER

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Publication number
AR041606A1
AR041606A1 ARP030103731A AR041606A1 AR 041606 A1 AR041606 A1 AR 041606A1 AR P030103731 A ARP030103731 A AR P030103731A AR 041606 A1 AR041606 A1 AR 041606A1
Authority
AR
Argentina
Prior art keywords
seq
antibody
antibody fragment
mammal
fragment
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Peter Devries
Larry Green
David Ostrow
Edward Reilly
James Wieler
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to ARP030103731 priority Critical patent/AR041606A1/en
Publication of AR041606A1 publication Critical patent/AR041606A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Reivindicación 1: Un anticuerpo, o un fragmento de anticuerpo del mismo, caracterizado porque estimula una actividad endógena del receptor de eritropoyetina humano en un mamífero pero no interactúa con un péptido cuya secuencia de aminoácidos del mismo es la SEQ ID Ns: 1. Reivindicación 1: Un anticuerpo, o un fragmento de anticuerpo del mismo, capaz de estimular una actividad endógena del receptor de eritropoyetina humano en un mamífero, caracterizado porque dicho anticuerpo, o un fragmento de anticuerpo, exhibe una afinidad de unión con el receptor de eritropoyetina que es cien veces mayor que la afinidad de unión de la eritropoyetina humana endógena. Reivindicación 44: Un método de tratamiento de un mamífero que sufre de aplasia, caracterizado porque dicho método comprende el paso de administrar a un mamífero que necesita el tratamiento una cantidad eficaz para uso terapéutico de un anticuerpo, o un fragmento de anticuerpo del mismo, para activar dicho receptor, donde dicho anticuerpo, o un fragmento de anticuerpo del mismo, no interactúa con un péptido cuya secuencia de aminoácidos es la SEQ ID Ns 1. Reivindicación 46: Una composición farmacéutica, caracterizada porque comprende una cantidad eficaz para uso terapéutico de un anticuerpo, o un fragmento de anticuerpo del mismo, y un excipiente aceptable para uso farmacéutico, donde dicho anticuerpo., o un fragmento de anticuerpo del mismo, no interactúa con un péptido cuya secuencia de aminoácidos es la SEQ ID Ns 1. Reivindicación 47: Una secuencia de polinucleótidos aislada y purificada, caracterizada porque se selecciona del grupo formado por: SEQ ID Ns:2, SEQ ID Ns: 4, SEQ ID Ns: 6, SEQ ID Ns: 8, SEQ ID Ns: 10, SEQ ID Ns: 12, SEQ ID Ns: 14, SEQ ID Ns: 16,, SEQ ID Ns: 18, SEQ ID Ns:20, SEQ ID Ns:22, SEQ ID Ns: 24, SEQ ID Ns: 26, SEQ ID Ns: 28, SEQ ID Ns:30, SEQ ID Ns:32, SEQ ID Ns:34, SEQ ID Ns:36, SEQ ID Ns: 38, SEQ ID Ns: 40, SEQ ID Ns: 42, SEQ ID Ns:44, SEQ ID Ns:46, SEQ ID Ns:48, SEQ ID Ns:50, SEQ ID Ns: 52, SEQ ID Ns: 54, SEQ ID Ns: 56, fragmentos, complementos, y equivalentes por degeneración de codones de la misma. Reivindicación 49: Un anticuerpo, o un fragmento de anticuerpo del mismo, que estimula una actividad endógena del receptor de eritropoyetina humano en un mamífero, caracterizado porque dicho anticuerpo, o un fragmento de anticuerpo, es el isotipo gamma-2. Reivindicación 50: El anticuerpo, o un fragmento de anticuerpo, de la cláusula 49, caracterizado porque dicho anticuerpo, o un fragmento de anticuerpo, es un anticuerpo monoclonal. Reivindicación 51: El anticuerpo, o un fragmento de anticuerpo, de la cláusula 50, caracterizado porque dicho anticuerpo, o un fragmento de anticuerpo, es un anticuerpo humanizado.Claim 1: An antibody, or an antibody fragment thereof, characterized in that it stimulates an endogenous activity of the human erythropoietin receptor in a mammal but does not interact with a peptide whose amino acid sequence thereof is SEQ ID Ns: 1. Claim 1 : An antibody, or an antibody fragment thereof, capable of stimulating an endogenous activity of the human erythropoietin receptor in a mammal, characterized in that said antibody, or an antibody fragment, exhibits a binding affinity with the erythropoietin receptor which is one hundred times greater than the binding affinity of endogenous human erythropoietin. Claim 44: A method of treating a mammal suffering from aplasia, characterized in that said method comprises the step of administering to an mammal in need of treatment an amount effective for therapeutic use of an antibody, or an antibody fragment thereof, for activating said receptor, wherein said antibody, or an antibody fragment thereof, does not interact with a peptide whose amino acid sequence is SEQ ID Ns 1. Claim 46: A pharmaceutical composition, characterized in that it comprises an amount effective for therapeutic use of a antibody, or an antibody fragment thereof, and an excipient acceptable for pharmaceutical use, wherein said antibody., or an antibody fragment thereof, does not interact with a peptide whose amino acid sequence is SEQ ID Ns 1. Claim 47: An isolated and purified polynucleotide sequence, characterized in that it is selected from the group consisting of: SEQ ID Ns: 2, SEQ I D Ns: 4, SEQ ID Ns: 6, SEQ ID Ns: 8, SEQ ID Ns: 10, SEQ ID Ns: 12, SEQ ID Ns: 14, SEQ ID Ns: 16 ,, SEQ ID Ns: 18, SEQ ID Ns: 20, SEQ ID Ns: 22, SEQ ID Ns: 24, SEQ ID Ns: 26, SEQ ID Ns: 28, SEQ ID Ns: 30, SEQ ID Ns: 32, SEQ ID Ns: 34, SEQ ID Ns: 36, SEQ ID Ns: 38, SEQ ID Ns: 40, SEQ ID Ns: 42, SEQ ID Ns: 44, SEQ ID Ns: 46, SEQ ID Ns: 48, SEQ ID Ns: 50, SEQ ID Ns: 52, SEQ ID Ns: 54, SEQ ID Ns: 56, fragments, complements, and equivalents by codon degeneration thereof. Claim 49: An antibody, or an antibody fragment thereof, that stimulates an endogenous activity of the human erythropoietin receptor in a mammal, characterized in that said antibody, or an antibody fragment, is the gamma-2 isotype. Claim 50: The antibody, or an antibody fragment, of clause 49, characterized in that said antibody, or an antibody fragment, is a monoclonal antibody. Claim 51: The antibody, or an antibody fragment, of clause 50, characterized in that said antibody, or an antibody fragment, is a humanized antibody.

ARP030103731 2003-10-14 2003-10-14 ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER AR041606A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP030103731 AR041606A1 (en) 2003-10-14 2003-10-14 ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP030103731 AR041606A1 (en) 2003-10-14 2003-10-14 ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER

Publications (1)

Publication Number Publication Date
AR041606A1 true AR041606A1 (en) 2005-05-26

Family

ID=42777685

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103731 AR041606A1 (en) 2003-10-14 2003-10-14 ANTIBODIES AGAINST THE ERYTHROPOYETINE RECEIVER

Country Status (1)

Country Link
AR (1) AR041606A1 (en)

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