AR040234A1 - INHIBITING LINKS OF RAR RECEPTORS AND THEIR USE IN HUMAN MEDICINE AS WELL AS IN COSMETICS - Google Patents
INHIBITING LINKS OF RAR RECEPTORS AND THEIR USE IN HUMAN MEDICINE AS WELL AS IN COSMETICSInfo
- Publication number
- AR040234A1 AR040234A1 ARP030101952A ARP030101952A AR040234A1 AR 040234 A1 AR040234 A1 AR 040234A1 AR P030101952 A ARP030101952 A AR P030101952A AR P030101952 A ARP030101952 A AR P030101952A AR 040234 A1 AR040234 A1 AR 040234A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- atom
- linear
- alkyl
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
- C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
- C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos biarílicos que responden a la fórmula general (1) así como su método de preparación, y su utilización en composiciones farmacéuticas destinadas a un uso en medicina humana o veterinaria, o también en composiciones cosméticas. Reivindicación 1: Compuestos caracterizados porque responden a la fórmula (1), en la cual: R1 representa un radical de fórmula (2) ó (3); R5 tiene las significaciones dadas a continuación; cada uno de R2 y R3, idénticos o diferentes, representan un átomo de H, un radical alquilo C1-6 lineales o ramificados, el radical -OR6, o el radical -NR7R8, o R2 y R3 tomados en forma conjunta, forman un ciclo de 6 eslabones eventualmente sustituidos por radicales alquilo C1-3 lineales o ramificados, R6, R7 y R8 tienen las significaciones dadas anteriormente; R4 representa un radical arilo o un radical heterociclo, X representa -CR9R10, un radical -C=O, o -C=N-OR11, R9, R10 y R11 tienen las significaciones dadas anteriormente; R5 representa un radical elegido entre las fórmulas (4) y (5); R12 y R13 tienen las significaciones dadas a continuación; R6 representa un átomo de H, un alquilo C1-6, o un radical bencilo eventualmente sustituido por un alquilo lineal o ramificado que tiene de 1 a 6 átomos de C, un halógeno, un radical dialquilamino o alcoxi, R7 y R8, idénticos o diferentes, representan un átomo de H, un radical alquilo que tiene de 1 a 6 átomos de C lineales o ramificados, o un radical bencilo, R9 representa un átomo de H, o un radical -OH; R10 y R11, idénticos o diferentes, representan un átomo de H o un radical alquilo lineal o ramificado que tiene de 1 a 6 átomos de C; R12 representa un grupo hidroxi, alcoxi, monoalquilamino, o dialquilamino; R13 representa un átomo de H, un radical hidroxi, o un radical amino; y los isómeros ópticos, las sales obtenidas con una sal o una base farmacéuticamente aceptable, así como las mezclas de dichos compuestos de fórmula (1).Biaryl compounds that respond to the general formula (1) as well as its method of preparation, and its use in pharmaceutical compositions intended for use in human or veterinary medicine, or also in cosmetic compositions. Claim 1: Compounds characterized in that they respond to formula (1), in which: R1 represents a radical of formula (2) or (3); R5 has the meanings given below; each of R2 and R3, identical or different, represent an H atom, a linear or branched C1-6 alkyl radical, the -OR6 radical, or the -NR7R8 radical, or R2 and R3 taken together, form a cycle of 6 links eventually substituted by linear or branched C1-3 alkyl radicals, R6, R7 and R8 have the meanings given above; R4 represents an aryl radical or a heterocycle radical, X represents -CR9R10, a radical -C = O, or -C = N-OR11, R9, R10 and R11 have the meanings given above; R5 represents a radical chosen between formulas (4) and (5); R12 and R13 have the meanings given below; R6 represents an H atom, a C1-6 alkyl, or a benzyl radical optionally substituted by a linear or branched alkyl having 1 to 6 C atoms, a halogen, a dialkylamino or alkoxy radical, R7 and R8, identical or different, they represent an H atom, an alkyl radical having 1 to 6 linear or branched C atoms, or a benzyl radical, R9 represents an H atom, or an -OH radical; R10 and R11, identical or different, represent an H atom or a linear or branched alkyl radical having 1 to 6 C atoms; R12 represents a hydroxy, alkoxy, monoalkylamino, or dialkylamino group; R13 represents an H atom, a hydroxy radical, or an amino radical; and optical isomers, salts obtained with a pharmaceutically acceptable salt or base, as well as mixtures of said compounds of formula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0206850A FR2840299B1 (en) | 2002-06-04 | 2002-06-04 | NEW RAR RECEPTOR INHIBITOR LIGANDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN MEDICINE AND COSMETICS |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040234A1 true AR040234A1 (en) | 2005-03-23 |
Family
ID=29558950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101952A AR040234A1 (en) | 2002-06-04 | 2003-06-02 | INHIBITING LINKS OF RAR RECEPTORS AND THEIR USE IN HUMAN MEDICINE AS WELL AS IN COSMETICS |
Country Status (9)
Country | Link |
---|---|
AR (1) | AR040234A1 (en) |
AT (1) | ATE500866T1 (en) |
CY (1) | CY1111485T1 (en) |
DE (1) | DE60336312D1 (en) |
DK (1) | DK1513793T3 (en) |
ES (1) | ES2361303T3 (en) |
FR (1) | FR2840299B1 (en) |
PT (1) | PT1513793E (en) |
SI (1) | SI1513793T1 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86387A1 (en) * | 1986-04-04 | 1987-12-07 | Oreal | AROMATIC COMPOUNDS, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND IN COSMETICS |
FR2764604B1 (en) * | 1997-06-13 | 1999-09-10 | Cird Galderma | BI-AROMATIC COMPOUNDS LINKED BY A PROPYNYLENE OR ALLENYLENE RADICAL AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM |
-
2002
- 2002-06-04 FR FR0206850A patent/FR2840299B1/en not_active Expired - Fee Related
-
2003
- 2003-05-27 DE DE60336312T patent/DE60336312D1/en not_active Expired - Lifetime
- 2003-05-27 PT PT03755947T patent/PT1513793E/en unknown
- 2003-05-27 SI SI200331968T patent/SI1513793T1/en unknown
- 2003-05-27 DK DK03755947.3T patent/DK1513793T3/en active
- 2003-05-27 ES ES03755947T patent/ES2361303T3/en not_active Expired - Lifetime
- 2003-05-27 AT AT03755947T patent/ATE500866T1/en active
- 2003-06-02 AR ARP030101952A patent/AR040234A1/en unknown
-
2011
- 2011-04-21 CY CY20111100411T patent/CY1111485T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK1513793T3 (en) | 2011-05-09 |
SI1513793T1 (en) | 2011-06-30 |
DE60336312D1 (en) | 2011-04-21 |
FR2840299B1 (en) | 2006-05-05 |
FR2840299A1 (en) | 2003-12-05 |
ATE500866T1 (en) | 2011-03-15 |
ES2361303T3 (en) | 2011-06-15 |
CY1111485T1 (en) | 2015-08-05 |
PT1513793E (en) | 2011-05-25 |
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