AR039175A1 - MORFOLINA DERIVATIVES, CCR3 ANTAGONISTS - Google Patents

MORFOLINA DERIVATIVES, CCR3 ANTAGONISTS

Info

Publication number
AR039175A1
AR039175A1 ARP030101088A ARP030101088A AR039175A1 AR 039175 A1 AR039175 A1 AR 039175A1 AR P030101088 A ARP030101088 A AR P030101088A AR P030101088 A ARP030101088 A AR P030101088A AR 039175 A1 AR039175 A1 AR 039175A1
Authority
AR
Argentina
Prior art keywords
morfolina
derivatives
substituted
ccr3 antagonists
alkyl
Prior art date
Application number
ARP030101088A
Other languages
Spanish (es)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR039175A1 publication Critical patent/AR039175A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1) en la que: R1 representa heterociclilo sustituido o no sustituido; Y representa -(CRnaRnb)n-; Cada uno de Rna y Rnb es independientemente H o alquilo C1-6; n es un número entero de 1 a 5; R2 representa arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; R3 representa H o alquilo C1-6; y sales o solvatos de los mismos; con la condición de que se excluyan los siguientes compuestos: N-{[4-(3,4-diclorobencil)morfolin-2-il]metil}-2-(1,1-dioxidotiomorfolin-4-il)acetamida).Claim 1: A compound of formula (1) wherein: R 1 represents substituted or unsubstituted heterocyclyl; Y represents - (CRnaRnb) n-; Each of Rna and Rnb is independently H or C1-6 alkyl; n is an integer from 1 to 5; R2 represents substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R3 represents H or C1-6 alkyl; and salts or solvates thereof; with the proviso that the following compounds are excluded: N - {[4- (3,4-dichlorobenzyl) morpholin-2-yl] methyl} -2- (1,1-dioxidothiomorpholin-4-yl) acetamide).

ARP030101088A 2002-03-28 2003-03-27 MORFOLINA DERIVATIVES, CCR3 ANTAGONISTS AR039175A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0207445.8A GB0207445D0 (en) 2002-03-28 2002-03-28 Novel compounds

Publications (1)

Publication Number Publication Date
AR039175A1 true AR039175A1 (en) 2005-02-09

Family

ID=9933995

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101088A AR039175A1 (en) 2002-03-28 2003-03-27 MORFOLINA DERIVATIVES, CCR3 ANTAGONISTS

Country Status (7)

Country Link
EP (1) EP1495020A1 (en)
JP (1) JP2005529094A (en)
AR (1) AR039175A1 (en)
AU (1) AU2003215677A1 (en)
GB (1) GB0207445D0 (en)
TW (1) TW200403239A (en)
WO (1) WO2003082863A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1801108T3 (en) 2004-09-08 2013-02-18 Mitsubishi Tanabe Pharma Corp Morpholine compounds for the treatment of inflammation.
JP2009501792A (en) * 2005-07-21 2009-01-22 アストラゼネカ・アクチエボラーグ N-benzyl-morpholine derivatives as modulators of chemokine receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19624668A1 (en) * 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Use of pyridylalkane, pyridylalken or pyridylalkynamides
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
KR20030031198A (en) * 2000-09-29 2003-04-18 글락소 그룹 리미티드 Morpholin-acetamide derivatives for the treatment of inflammatory diseases

Also Published As

Publication number Publication date
TW200403239A (en) 2004-03-01
JP2005529094A (en) 2005-09-29
AU2003215677A1 (en) 2003-10-13
WO2003082863A1 (en) 2003-10-09
EP1495020A1 (en) 2005-01-12
GB0207445D0 (en) 2002-05-08

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