AR035928A1 - PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS - Google Patents

PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS

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Publication number
AR035928A1
AR035928A1 ARP010105380A AR035928A1 AR 035928 A1 AR035928 A1 AR 035928A1 AR P010105380 A ARP010105380 A AR P010105380A AR 035928 A1 AR035928 A1 AR 035928A1
Authority
AR
Argentina
Prior art keywords
optically active
synthesis
anthraciclines
procedure
formula
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Bugno Cristina Di
Arata Fabio D
Alessio Ramacciotti
Paolo Crotti
Original Assignee
Menarini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche Spa filed Critical Menarini Ricerche Spa
Priority to ARP010105380 priority Critical patent/AR035928A1/en
Publication of AR035928A1 publication Critical patent/AR035928A1/en

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Abstract

Procedimiento para la síntesis de antraciclinas ópticamente activas de fórmula (1) donde R1, = H, OH, OCH3; R2 = H, OH; R3 es de fórmula (2) (3) o (4) que comprende la formación del intermediario de fórmula (5) donde R=C1-3, alquilo, donde dicho intermediario de la fórmula (1) es obtenido a partir de un 5,8-dialcoxi-3,4-dehidronaftaleno de fórmula (6), donde R=C1-3alquilo. Además un compuesto ópticamente activo caracterizado por la fórmula general (7) y un compuesto ópticamente activo caracterizado por la fórmula general (8).Method for the synthesis of optically active anthracyclines of formula (1) wherein R1, = H, OH, OCH3; R2 = H, OH; R3 is of formula (2) (3) or (4) comprising the formation of the intermediary of formula (5) where R = C1-3, alkyl, wherein said intermediary of the formula (1) is obtained from a , 8-dialkoxy-3,4-dehydronaphthalene of formula (6), where R = C1-3alkyl. In addition, an optically active compound characterized by the general formula (7) and an optically active compound characterized by the general formula (8).

ARP010105380 2001-11-16 2001-11-16 PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS AR035928A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP010105380 AR035928A1 (en) 2001-11-16 2001-11-16 PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP010105380 AR035928A1 (en) 2001-11-16 2001-11-16 PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS

Publications (1)

Publication Number Publication Date
AR035928A1 true AR035928A1 (en) 2004-07-28

Family

ID=42632492

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105380 AR035928A1 (en) 2001-11-16 2001-11-16 PROCEDURE FOR SYNTHESIS OF OPTICALLY ACTIVE ANTHRACICLINES AND REACTION INTERMEDIARIES USED IN THIS PROCESS

Country Status (1)

Country Link
AR (1) AR035928A1 (en)

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