AR035226A1 - DERIVATIVES OF RENT-PHENYLIMINE-IMIDAZOLIDINE FOR THE TREATMENT OF URINARY INCONTINENCE. - Google Patents
DERIVATIVES OF RENT-PHENYLIMINE-IMIDAZOLIDINE FOR THE TREATMENT OF URINARY INCONTINENCE.Info
- Publication number
- AR035226A1 AR035226A1 ARP020100417A ARP020100417A AR035226A1 AR 035226 A1 AR035226 A1 AR 035226A1 AR P020100417 A ARP020100417 A AR P020100417A AR P020100417 A ARP020100417 A AR P020100417A AR 035226 A1 AR035226 A1 AR 035226A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- urinary incontinence
- ch2f
- chf2
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Abstract
Derivados de m-alquil-fenilimino-imidazolidina con un nuevo modelo de sustituyentes en el anillo de fenilo y su uso para la preparación de medicamentos, en particular para el tratamiento de la incontinencia urinaria. Reivindicación 1: Compuesto de fórmula general (1) en donde R1 ó R5 son, independientemente uno de otro, H, F, Cl, Br, CH2F, CHF2, CF3, Me u OMe; R2 y R4 son, en cada caso independientemente uno de otro, H, alquilo C3-6 ramificado, F, Cl, Br, CH2F, CHF2, CF3 ó Me, siendo al menos uno de los radicales R2 o R4 el alquilo C3-6 ramificado; y R3 es H, F, Cl, Br, CH2F, CHF2, CF3 ó Me; y/o una sal fisiológicamente aceptable, así como las formas tautómeras correspondientes de los compuestos según la fórmula (2) y/o una sal farmacológicamente aceptable del mismo.M-alkyl-phenylimino-imidazolidine derivatives with a new model of substituents on the phenyl ring and their use for the preparation of medications, in particular for the treatment of urinary incontinence. Claim 1: Compound of general formula (1) wherein R1 or R5 are, independently of one another, H, F, Cl, Br, CH2F, CHF2, CF3, Me or OMe; R2 and R4 are, in each case independently of each other, H, branched C3-6 alkyl, F, Cl, Br, CH2F, CHF2, CF3 or Me, with at least one of the radicals R2 or R4 being C3-6 alkyl branched; and R3 is H, F, Cl, Br, CH2F, CHF2, CF3 or Me; and / or a physiologically acceptable salt, as well as the corresponding tautomeric forms of the compounds according to formula (2) and / or a pharmacologically acceptable salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10106214A DE10106214A1 (en) | 2001-02-10 | 2001-02-10 | New alkyl-phenylimino-imidazolidine derivatives for the treatment of urinary incontinence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035226A1 true AR035226A1 (en) | 2004-05-05 |
Family
ID=7673601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100417A Withdrawn AR035226A1 (en) | 2001-02-10 | 2002-02-08 | DERIVATIVES OF RENT-PHENYLIMINE-IMIDAZOLIDINE FOR THE TREATMENT OF URINARY INCONTINENCE. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1362038A1 (en) |
| JP (1) | JP2004517963A (en) |
| KR (1) | KR20030076653A (en) |
| CN (1) | CN1491216A (en) |
| AR (1) | AR035226A1 (en) |
| BG (1) | BG108036A (en) |
| BR (1) | BR0206949A (en) |
| CA (1) | CA2437809A1 (en) |
| CZ (1) | CZ20032146A3 (en) |
| DE (1) | DE10106214A1 (en) |
| EA (1) | EA200300835A1 (en) |
| EC (1) | ECSP034700A (en) |
| EE (1) | EE200300379A (en) |
| HU (1) | HUP0303004A3 (en) |
| IL (1) | IL157297A0 (en) |
| MX (1) | MXPA03007127A (en) |
| NO (1) | NO20033368D0 (en) |
| PL (1) | PL362149A1 (en) |
| SK (1) | SK10132003A3 (en) |
| WO (1) | WO2002064570A1 (en) |
| ZA (1) | ZA200305609B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100751163B1 (en) * | 2003-05-09 | 2007-08-22 | 에프. 호프만-라 로슈 아게 | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists |
| JP4168086B1 (en) * | 2008-04-16 | 2008-10-22 | 国立大学法人福井大学 | Imidazoline derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3190802A (en) * | 1961-10-09 | 1965-06-22 | Boehringer Sohn Ingelheim | Shaving composition and method of using same |
| HU192986B (en) * | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| DE19514579A1 (en) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Use of alpha-1-olone agonists for the treatment of urinary incontinence |
| FR2761061B1 (en) * | 1997-03-20 | 1999-04-23 | Synthelabo | BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
-
2001
- 2001-02-10 DE DE10106214A patent/DE10106214A1/en not_active Withdrawn
-
2002
- 2002-01-22 SK SK1013-2003A patent/SK10132003A3/en unknown
- 2002-01-22 IL IL15729702A patent/IL157297A0/en unknown
- 2002-01-22 CN CNA02804570XA patent/CN1491216A/en active Pending
- 2002-01-22 CA CA002437809A patent/CA2437809A1/en not_active Abandoned
- 2002-01-22 WO PCT/EP2002/000576 patent/WO2002064570A1/en not_active Application Discontinuation
- 2002-01-22 CZ CZ20032146A patent/CZ20032146A3/en unknown
- 2002-01-22 MX MXPA03007127A patent/MXPA03007127A/en unknown
- 2002-01-22 JP JP2002564503A patent/JP2004517963A/en active Pending
- 2002-01-22 EP EP02704665A patent/EP1362038A1/en not_active Withdrawn
- 2002-01-22 HU HU0303004A patent/HUP0303004A3/en unknown
- 2002-01-22 BR BR0206949-0A patent/BR0206949A/en active Pending
- 2002-01-22 EE EEP200300379A patent/EE200300379A/en unknown
- 2002-01-22 EA EA200300835A patent/EA200300835A1/en unknown
- 2002-01-22 PL PL36214902A patent/PL362149A1/en not_active Application Discontinuation
- 2002-01-22 KR KR10-2003-7010280A patent/KR20030076653A/en not_active Application Discontinuation
- 2002-02-08 AR ARP020100417A patent/AR035226A1/en not_active Withdrawn
-
2003
- 2003-07-21 ZA ZA200305609A patent/ZA200305609B/en unknown
- 2003-07-22 EC EC2003004700A patent/ECSP034700A/en unknown
- 2003-07-28 NO NO20033368A patent/NO20033368D0/en not_active Application Discontinuation
- 2003-07-28 BG BG108036A patent/BG108036A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL362149A1 (en) | 2004-10-18 |
| BG108036A (en) | 2004-12-30 |
| NO20033368L (en) | 2003-07-28 |
| CN1491216A (en) | 2004-04-21 |
| HUP0303004A2 (en) | 2003-12-29 |
| JP2004517963A (en) | 2004-06-17 |
| ECSP034700A (en) | 2003-08-29 |
| NO20033368D0 (en) | 2003-07-28 |
| WO2002064570A1 (en) | 2002-08-22 |
| CZ20032146A3 (en) | 2003-12-17 |
| CA2437809A1 (en) | 2002-08-22 |
| SK10132003A3 (en) | 2004-02-03 |
| ZA200305609B (en) | 2004-04-29 |
| MXPA03007127A (en) | 2003-11-18 |
| BR0206949A (en) | 2004-02-25 |
| DE10106214A1 (en) | 2002-08-14 |
| HUP0303004A3 (en) | 2004-07-28 |
| EA200300835A1 (en) | 2004-02-26 |
| EE200300379A (en) | 2003-12-15 |
| EP1362038A1 (en) | 2003-11-19 |
| IL157297A0 (en) | 2004-02-19 |
| KR20030076653A (en) | 2003-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |