AR032573A1 - PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE - Google Patents
PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINEInfo
- Publication number
- AR032573A1 AR032573A1 ARP020100590A ARP020100590A AR032573A1 AR 032573 A1 AR032573 A1 AR 032573A1 AR P020100590 A ARP020100590 A AR P020100590A AR P020100590 A ARP020100590 A AR P020100590A AR 032573 A1 AR032573 A1 AR 032573A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- aralkyl
- alkynyl
- alkenyl
- alkyl
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un análogo de nucleosido de acuerdo con la formula (1) en donde: A es O, S o CH2; X es H, NH2 u OH; Y es H, halogeno o NH2; C* se dirige a la orientacion beta y es un átomo de carbono secundario unido covalentemente a un átomo de oxígeno o átomo de fosforo; Z se selecciona del grupo que consiste de H, halogeno, R, OH, OR, SH, SR, NH2, NHR, NR2, CN, C(O)NH2, COOH, COOR, CH2NH2, C(=NOH)NH2 y C(=NH)NH2, en donde R es alquilo, alquenilo, alquinilo o aralquilo; R2 y R3 se seleccionan independientemente del grupo que consiste de H, F y OH; R4 se selecciona del grupo que consiste de un hidrogeno, un alquilo, un alquenilo, un alquinilo, y un aralquilo, en donde R4 tiene opcionalmente por lo menos un heteroátomo y un grupo funcional; R5 es OH, OP(O)(OH)2, P(O)(OH)2, OP(O)(OR')2, o P(O)(OR')2, en donde R' es un grupo de enmascaramiento; y R5' se selecciona del grupo que consiste de un alquilo, un alquenilo, un alquinilo, y un aralquilo, en donde R5' posee por lo menos dos átomos de carbono, y por lo menos posee opcionalmente un heteroátomo y un grupo funcional. Utiles en terapias anticáncer, antiviral y enfermedades autoinmunes.A nucleoside analog according to formula (1) wherein: A is O, S or CH2; X is H, NH2 or OH; Y is H, halogen or NH2; C * is directed to the beta orientation and is a secondary carbon atom covalently bonded to an oxygen atom or phosphorus atom; Z is selected from the group consisting of H, halogen, R, OH, OR, SH, SR, NH2, NHR, NR2, CN, C (O) NH2, COOH, COOR, CH2NH2, C (= NOH) NH2 and C (= NH) NH2, where R is alkyl, alkenyl, alkynyl or aralkyl; R2 and R3 are independently selected from the group consisting of H, F and OH; R4 is selected from the group consisting of a hydrogen, an alkyl, an alkenyl, an alkynyl, and an aralkyl, wherein R4 optionally has at least one heteroatom and a functional group; R5 is OH, OP (O) (OH) 2, P (O) (OH) 2, OP (O) (OR ') 2, or P (O) (OR') 2, where R 'is a group masking; and R5 'is selected from the group consisting of an alkyl, an alkenyl, an alkynyl, and an aralkyl, wherein R5' possesses at least two carbon atoms, and at least optionally possesses a heteroatom and a functional group. Useful in anticancer, antiviral and autoimmune diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP020100590A AR032573A1 (en) | 2002-02-21 | 2002-02-21 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP020100590A AR032573A1 (en) | 2002-02-21 | 2002-02-21 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032573A1 true AR032573A1 (en) | 2003-11-12 |
Family
ID=37516290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100590A AR032573A1 (en) | 2002-02-21 | 2002-02-21 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR032573A1 (en) |
-
2002
- 2002-02-21 AR ARP020100590A patent/AR032573A1/en unknown
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| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |