AR032362A1 - STABLE TOPICAL FORMULATION OF A WATER OIL EMULSION AND PROCESS FOR PREPARATION - Google Patents

STABLE TOPICAL FORMULATION OF A WATER OIL EMULSION AND PROCESS FOR PREPARATION

Info

Publication number
AR032362A1
AR032362A1 ARP010103841A ARP010103841A AR032362A1 AR 032362 A1 AR032362 A1 AR 032362A1 AR P010103841 A ARP010103841 A AR P010103841A AR P010103841 A ARP010103841 A AR P010103841A AR 032362 A1 AR032362 A1 AR 032362A1
Authority
AR
Argentina
Prior art keywords
group
preparation
fluorine
oil emulsion
topical formulation
Prior art date
Application number
ARP010103841A
Other languages
Spanish (es)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR032362A1 publication Critical patent/AR032362A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una formulacion dermatologica para aplicacion topica, que incluye un solvente un agente oclusivo, un sistema de agente tensioactivo, un compuesto esteroide de androstano de la formula (1) en donde R1 representa un grupo fluor -, cloro- o bromo-metilo o un grupo 2'-fluorometilo, R2 representa un grupo COR6 donde R6 es un grupo alquilo C1-3 u OR2 y R3 juntos forman un grupo 16alfa, 17alfa-isopropiliendioxi; R3 representa un átomo de hidrogeno, un grupo metilo (que puede estar tanto en la configuracion alfa o beta) o un grupo metileno; R4 representa un átomo de hidrogeno, cloro o fluor; R5 representa un átomo de hidrogeno, o fluor y el símbolo--- representa un enlace simple o doble; y el balance es agua. Además se da a conocer un proceso para la preparacion de tal formulacion. .A dermatological formulation for topical application, which includes a solvent an occlusive agent, a surfactant system, an androstane steroid compound of the formula (1) wherein R 1 represents a fluorine -, chloro- or bromo-methyl group or a group 2'-fluoromethyl, R2 represents a COR6 group where R6 is a C1-3 or OR2 alkyl group and R3 together form a 16alpha, 17alpha-isopropylenedioxy group; R3 represents a hydrogen atom, a methyl group (which can be in both the alpha or beta configuration) or a methylene group; R4 represents a hydrogen, chlorine or fluorine atom; R5 represents a hydrogen atom, or fluorine and the symbol --- represents a single or double bond; And the balance is water. In addition, a process for the preparation of such a formulation is disclosed. .

ARP010103841A 2000-08-14 2001-08-10 STABLE TOPICAL FORMULATION OF A WATER OIL EMULSION AND PROCESS FOR PREPARATION AR032362A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22532800P 2000-08-14 2000-08-14

Publications (1)

Publication Number Publication Date
AR032362A1 true AR032362A1 (en) 2003-11-05

Family

ID=22844446

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103841A AR032362A1 (en) 2000-08-14 2001-08-10 STABLE TOPICAL FORMULATION OF A WATER OIL EMULSION AND PROCESS FOR PREPARATION

Country Status (5)

Country Link
EP (1) EP1309351A1 (en)
JP (1) JP2004506023A (en)
AR (1) AR032362A1 (en)
AU (1) AU2001283344A1 (en)
WO (1) WO2002013868A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
FR2850276B1 (en) * 2003-01-23 2005-03-04 Louis Gerald Alcindor ANTI-EXCESSING AND / OR ANTI-DESQUAMANT AND / OR ANTI-EXFOLIANT COMPOSITION
US7897587B2 (en) 2004-09-03 2011-03-01 Nycomed Us Inc. Topical dermatological formulations and use thereof
MX2008007439A (en) * 2005-12-09 2009-01-22 Nycomed Inc Topical glucocorticosteroid formulations.
FR2898498B1 (en) 2006-03-15 2008-11-28 Galderma Sa NOVEL TOPIC COMPOSITIONS IN THE FORM OF O / W EMULSION COMPRISING PRO-PENETRANT GLYCOL
JP2011045316A (en) * 2009-08-28 2011-03-10 T Hasegawa Co Ltd Triacetin-mixed oil-in-water type emulsion composition
FR2970175B1 (en) * 2011-01-10 2013-07-26 Oreal PROCESS FOR COLORING OR LIGHTENING TWO-PIECE KERATIN FIBERS USING DIRECT OIL-RICH EMULSION BASED ON SOLID FATTY ALCOHOL AND DIFFERENT OILS OF POLARITY.
FR2970176B1 (en) 2011-01-10 2015-01-02 Oreal PROCESS FOR COLORING OR LIGHTENING TWO-PART KERATIN FIBERS FROM OIL-RICH DIRECT ALKALINE EMULSION BASED ON SOLID NON-IONIC SURFACTANT OF HLB RANGING FROM 1.5 TO 10
FR2970173B1 (en) * 2011-01-10 2013-07-05 Oreal COLORING OR LIGHTENING PROCESS USING A RICH BODY COMPOSITION COMPRISING A SOLID ALCOHOL AND ESTER, COMPOSITIONS AND DEVICE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103764D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Compositions
US6075056A (en) * 1997-10-03 2000-06-13 Penederm, Inc. Antifungal/steroid topical compositions
GB9823036D0 (en) * 1998-10-22 1998-12-16 Glaxo Group Ltd Fluticasone lotion having improved vasoconstrictor activity

Also Published As

Publication number Publication date
AU2001283344A1 (en) 2002-02-25
JP2004506023A (en) 2004-02-26
EP1309351A1 (en) 2003-05-14
WO2002013868A1 (en) 2002-02-21

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