AR030999A1 - ANTIBACTERIAL AGENTS CONTAINING CETOLIDE - Google Patents

ANTIBACTERIAL AGENTS CONTAINING CETOLIDE

Info

Publication number
AR030999A1
AR030999A1 ARP010104875A ARP010104875A AR030999A1 AR 030999 A1 AR030999 A1 AR 030999A1 AR P010104875 A ARP010104875 A AR P010104875A AR P010104875 A ARP010104875 A AR P010104875A AR 030999 A1 AR030999 A1 AR 030999A1
Authority
AR
Argentina
Prior art keywords
heterocycle
aryl
alkynyl
alkyl
alkenyl
Prior art date
Application number
ARP010104875A
Other languages
Spanish (es)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to ARP010104875A priority Critical patent/AR030999A1/en
Publication of AR030999A1 publication Critical patent/AR030999A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Incluye compuestos de la formula (1) en la cual: X es hidrogreno o haluro; R2 es hidrogeno, acilo o un grupo protector hidroxi; R6 es hidrogeno, hidroxilo u -ORa en la cual Ra es un grupo funcional sustituido o no sustituido seleccionado del grupo que consiste de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, arilo, heterociclo, aril(C1-10)alquilo, aril(C2-10)alquenilo, aril(C2-10)alquinilo, heterociclo(C1-10)alquilo, heterociclo(C2-10)alquenilo y heterociclo(C2-10)alquinilo; R13 es hidrogeno o un grupo funcional sustituido o no sustituido en el cual el grupo funcional se selecciona del grupo que consiste de metilo, alquilo C3-10, alquenilo C2-10, alquinilo C2-10, arilo, heterociclo, aril(C1-10)alquilo, aril(C2-10)alquenilo y heterociclo(C2-10)alquinilo; y R es hidrogeno o un grupo funcional sustituido o no sustituido en el cual el grupo que consiste de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, arilo, heterociclo, aril(C1-10)alquilo, aril(C2-10)alquenilo, aril(C2-10)alquinilo, heterociclo(C1-10)alquilo, heterociclo(C2-10)alquenilo y heterociclo(C2-10)alquinilo; y sus sales, ésteres y prodrogas aceptables para uso farmacéutico. Estos compuestos poseen actividad anti-infecciosa y son utiles para el tratamiento de infecciones bacterianas o protozooicas.It includes compounds of the formula (1) in which: X is hydrogrene or halide; R2 is hydrogen, acyl or a hydroxy protecting group; R6 is hydrogen, hydroxyl or -ORa in which Ra is a substituted or unsubstituted functional group selected from the group consisting of C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heterocycle, aryl (C1-10 ) alkyl, (C2-10) alkenyl, aryl (C2-10) alkynyl, heterocycle (C1-10) alkyl, heterocycle (C2-10) alkenyl and heterocycle (C2-10) alkynyl; R13 is hydrogen or a substituted or unsubstituted functional group in which the functional group is selected from the group consisting of methyl, C3-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heterocycle, aryl (C1-10 ) alkyl, (C2-10) aryl, and (C2-10) alkynyl heterocycle; and R is hydrogen or a substituted or unsubstituted functional group in which the group consisting of C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heterocycle, aryl (C1-10) alkyl, aryl (C2 -10) alkenyl, aryl (C2-10) alkynyl, heterocycle (C1-10) alkyl, heterocycle (C2-10) alkenyl and heterocycle (C2-10) alkynyl; and its salts, esters and prodrugs acceptable for pharmaceutical use. These compounds possess anti-infectious activity and are useful for the treatment of bacterial or protozoan infections.

ARP010104875A 2001-10-17 2001-10-17 ANTIBACTERIAL AGENTS CONTAINING CETOLIDE AR030999A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP010104875A AR030999A1 (en) 2001-10-17 2001-10-17 ANTIBACTERIAL AGENTS CONTAINING CETOLIDE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP010104875A AR030999A1 (en) 2001-10-17 2001-10-17 ANTIBACTERIAL AGENTS CONTAINING CETOLIDE

Publications (1)

Publication Number Publication Date
AR030999A1 true AR030999A1 (en) 2003-09-03

Family

ID=37515965

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104875A AR030999A1 (en) 2001-10-17 2001-10-17 ANTIBACTERIAL AGENTS CONTAINING CETOLIDE

Country Status (1)

Country Link
AR (1) AR030999A1 (en)

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