AR030740A2 - A COMPOUND DERIVED FROM N-GLIOXYLPROLINE AND A METHOD TO PREPARE IT - Google Patents
A COMPOUND DERIVED FROM N-GLIOXYLPROLINE AND A METHOD TO PREPARE ITInfo
- Publication number
- AR030740A2 AR030740A2 ARP010104365A ARP010104365A AR030740A2 AR 030740 A2 AR030740 A2 AR 030740A2 AR P010104365 A ARP010104365 A AR P010104365A AR P010104365 A ARP010104365 A AR P010104365A AR 030740 A2 AR030740 A2 AR 030740A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkenyl
- cycloalkyl
- hydrogen
- compound derived
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
01-4365 Un compuesto derivado de la N-glioxilprolina, caracterizado por la formula: en donde R1 representa: -un grupo alquilo C1-9 o alquenilo C1-9 de cadena recta o ramificada opcionalmente sustituidos con cicloalquilo C3-8, cicloalquilo C3 o C5, cicloalquenilo C5-7, en donde dichos grupos alquilo, alquenilo, cicloalquilo o cicloalquenilo pueden estar opcionalmente sustituidos con alquilo C1-4, alquenilo C1-4 o hidroxi, o Ar1, en donde Ar1 es seleccionado del grupo formado por 1-naftilo, 2-naftilo, 2-indolillo, 3-indolilo, 2-furilo, 3-furilo, 2-tiazolilo, 2-tienilo, 3-tienilo, 2-, 3- o 4-piridilo y fenilo, teniendo uno o tres sustituyentes que son independientemente seleccionados del grupo formado por hidrogeno, halogeno, hidroxilo, nitro, trifluorometilo, alquilo C1-6 o alquenilo C1-6 recto o ramificado, alcoxi C1-4 o alqueniloxi C1-4, fenoxi, benciloxi y amino; X es oxígeno o azufre; Y es oxígeno o NR2, en donde R2 es hidrogeno o alquilo C1-6; y Z representa hidrogeno (H), y un método para preparar dicho compuesto.01-4365 A compound derived from N-glyoxylproline, characterized by the formula: wherein R1 represents: -a C1-9 alkyl or straight- or branched C1-9 alkenyl group optionally substituted with C3-8 cycloalkyl, C3 cycloalkyl or C5, C5-7 cycloalkenyl, wherein said alkyl, alkenyl, cycloalkyl or cycloalkenyl groups may be optionally substituted with C1-4 alkyl, C1-4 alkenyl or hydroxy, or Ar1, wherein Ar1 is selected from the group consisting of 1-naphthyl , 2-naphthyl, 2-indolillo, 3-indolyl, 2-furyl, 3-furyl, 2-thiazolyl, 2-thienyl, 3-thienyl, 2-, 3- or 4-pyridyl and phenyl, having one or three substituents which are independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, trifluoromethyl, C1-6 alkyl or straight or branched C1-6 alkenyl, C1-4 alkoxy or C1-4 alkenyloxy, phenoxy, benzyloxy and amino; X is oxygen or sulfur; Y is oxygen or NR2, where R2 is hydrogen or C1-6 alkyl; and Z represents hydrogen (H), and a method for preparing said compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/650,461 US5859031A (en) | 1995-06-07 | 1996-05-21 | Small molecule inhibitors of rotamase enzyme activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030740A2 true AR030740A2 (en) | 2003-09-03 |
Family
ID=24609008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104916A AR004695A1 (en) | 1996-05-21 | 1996-10-25 | NEUROTROPHIC COMPOUNDS AND COMPOSITIONS THAT HAVE AFFINITY WITH FKBP TYPE IMMUNOFILINS, AND APPLICATIONS OF THOSE. |
| ARP010104364A AR030739A2 (en) | 1996-05-21 | 2001-09-14 | A NON-IMMUNOSUPRESSIVE COMPOUND DERIVED FROM N-GLIOXYLPROLINE, A METHOD TO PREPARE IT AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT |
| ARP010104365A AR030740A2 (en) | 1996-05-21 | 2001-09-14 | A COMPOUND DERIVED FROM N-GLIOXYLPROLINE AND A METHOD TO PREPARE IT |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104916A AR004695A1 (en) | 1996-05-21 | 1996-10-25 | NEUROTROPHIC COMPOUNDS AND COMPOSITIONS THAT HAVE AFFINITY WITH FKBP TYPE IMMUNOFILINS, AND APPLICATIONS OF THOSE. |
| ARP010104364A AR030739A2 (en) | 1996-05-21 | 2001-09-14 | A NON-IMMUNOSUPRESSIVE COMPOUND DERIVED FROM N-GLIOXYLPROLINE, A METHOD TO PREPARE IT AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT |
Country Status (4)
| Country | Link |
|---|---|
| AR (3) | AR004695A1 (en) |
| ID (1) | ID16707A (en) |
| TW (2) | TW453992B (en) |
| ZA (1) | ZA968983B (en) |
-
1996
- 1996-10-24 TW TW85113067A patent/TW453992B/en not_active IP Right Cessation
- 1996-10-24 TW TW88118312A patent/TWI252226B/en not_active IP Right Cessation
- 1996-10-25 AR ARP960104916A patent/AR004695A1/en unknown
- 1996-10-25 ZA ZA968983A patent/ZA968983B/en unknown
- 1996-10-25 ID IDP963062A patent/ID16707A/en unknown
-
2001
- 2001-09-14 AR ARP010104364A patent/AR030739A2/en unknown
- 2001-09-14 AR ARP010104365A patent/AR030740A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW453992B (en) | 2001-09-11 |
| ID16707A (en) | 1997-11-06 |
| AR004695A1 (en) | 1999-03-10 |
| ZA968983B (en) | 1998-07-27 |
| TWI252226B (en) | 2006-04-01 |
| AR030739A2 (en) | 2003-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |