AR029960A1 - USE OF PIRIDAZINO DERIVATIVES [4,5-BETA] INDOL-1-ACETAMIDE FOR THE PREPARATION OF DRUGS INTENDED FOR THE TREATMENT OF PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL TYPE RECEIVERS OF BENZODIAZEPINAS - Google Patents

USE OF PIRIDAZINO DERIVATIVES [4,5-BETA] INDOL-1-ACETAMIDE FOR THE PREPARATION OF DRUGS INTENDED FOR THE TREATMENT OF PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL TYPE RECEIVERS OF BENZODIAZEPINAS

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Publication number
AR029960A1
AR029960A1 ARP010103502A ARP010103502A AR029960A1 AR 029960 A1 AR029960 A1 AR 029960A1 AR P010103502 A ARP010103502 A AR P010103502A AR P010103502 A ARP010103502 A AR P010103502A AR 029960 A1 AR029960 A1 AR 029960A1
Authority
AR
Argentina
Prior art keywords
group
dysfunction
preparation
treatment
benzodiazepinas
Prior art date
Application number
ARP010103502A
Other languages
Spanish (es)
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of AR029960A1 publication Critical patent/AR029960A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Utilizacion de un compuesto en estado de base o de sal de adicion con un ácido, que responde a la formula general (1) en la cual X representa un átomo de halogeno, Y representa uno o varios átomos o grupos elegidos entre el hidrogeno, los halogenos y los grupos hidroxi, metilo y metoxi, R1 representa un átomos de hidrogeno o un grupo alquilo, R2 representa un átomos de hidrogeno, un grupo alquilo, un grupo hidroxialquilo, un grupo cicloalquilo, un grupo cicloalquilalquilo, un grupo fenilo, un grupo piridinilo o un grupo fenilalquilo, para la preparacion de un medicamento destinado a la prevencion o al tratamiento de una enfermedad relacionada con la disfuncion de los receptores de tipo periférico de benzodiazepinas.Use of a compound in the base or addition salt state with an acid, which responds to the general formula (1) in which X represents a halogen atom, Y represents one or more atoms or groups chosen from hydrogen, halogens and hydroxy, methyl and methoxy groups, R1 represents a hydrogen atoms or an alkyl group, R2 represents a hydrogen atoms, an alkyl group, a hydroxyalkyl group, a cycloalkyl group, a cycloalkylalkyl group, a phenyl group, a group pyridinyl or a phenylalkyl group, for the preparation of a medicament intended for the prevention or treatment of a disease related to the dysfunction of the peripheral benzodiazepine type receptors.

ARP010103502A 2000-07-24 2001-07-23 USE OF PIRIDAZINO DERIVATIVES [4,5-BETA] INDOL-1-ACETAMIDE FOR THE PREPARATION OF DRUGS INTENDED FOR THE TREATMENT OF PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL TYPE RECEIVERS OF BENZODIAZEPINAS AR029960A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0009655A FR2811897A1 (en) 2000-07-24 2000-07-24 Treatment of diseases associated with peripheral benzodiazepine receptor dysfunction, e.g. peripheral neuropathy, cardiac insufficiency or cancer, using pyridazino(4,5-b)indole-1-acetamide derivatives

Publications (1)

Publication Number Publication Date
AR029960A1 true AR029960A1 (en) 2003-07-23

Family

ID=8852829

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103502A AR029960A1 (en) 2000-07-24 2001-07-23 USE OF PIRIDAZINO DERIVATIVES [4,5-BETA] INDOL-1-ACETAMIDE FOR THE PREPARATION OF DRUGS INTENDED FOR THE TREATMENT OF PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL TYPE RECEIVERS OF BENZODIAZEPINAS

Country Status (4)

Country Link
AR (1) AR029960A1 (en)
AU (1) AU2001278549A1 (en)
FR (1) FR2811897A1 (en)
WO (1) WO2002007727A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838124B1 (en) * 2002-04-03 2004-05-28 Sanofi Synthelabo 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-B] INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2879451B1 (en) * 2004-12-20 2007-05-04 Oreal USE OF BENZODIAZEPINE RECEPTOR LIGANDS TO FIGHT AGING SIGNS
US20080194620A1 (en) * 2004-12-20 2008-08-14 L'oreal Use of Benzodiazepine Receptor Ligands For Combating Signs of Ageing
WO2006067327A2 (en) * 2004-12-20 2006-06-29 L'oreal Benzodiazepine peripheral receptor antagonists for treating dry skin
FR2879450B1 (en) * 2004-12-20 2007-02-09 Oreal ANTAGONISTS OF PERIPHERAL RECEPTORS OF BENZODIAZEPINES FOR THE TREATMENT OF DRY SKINS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
FR2754262B1 (en) * 1996-10-08 1998-10-30 Synthelabo 1H-PYRIDO [3,4-B] INDOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2766823B1 (en) * 1997-07-30 1999-10-08 Synthelabo 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO [4,5-B] INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2788696B1 (en) * 1999-01-26 2004-03-05 Synthelabo USE OF PYRIDAZINO [4,5-B] INDOLE-1-ACETAMIDE DERIVATIVES FOR THE PREPARATION OF MEDICINES FOR DISEASES OF THE CENTRAL NERVOUS SYSTEM

Also Published As

Publication number Publication date
AU2001278549A1 (en) 2002-02-05
FR2811897A1 (en) 2002-01-25
WO2002007727A1 (en) 2002-01-31

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