AR029766A1 - QUINASE INHIBITOR COMPOUND AND USE OF IT TO PREPARE A PHARMACEUTICAL COMPOSITION - Google Patents

QUINASE INHIBITOR COMPOUND AND USE OF IT TO PREPARE A PHARMACEUTICAL COMPOSITION

Info

Publication number
AR029766A1
AR029766A1 ARP000104887A ARP000104887A AR029766A1 AR 029766 A1 AR029766 A1 AR 029766A1 AR P000104887 A ARP000104887 A AR P000104887A AR P000104887 A ARP000104887 A AR P000104887A AR 029766 A1 AR029766 A1 AR 029766A1
Authority
AR
Argentina
Prior art keywords
prepare
inhibitor compound
quinase
pharmaceutical composition
formula
Prior art date
Application number
ARP000104887A
Other languages
Spanish (es)
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22552056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR029766(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR029766A1 publication Critical patent/AR029766A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Un compuesto inhibidor de quinasa de Formula 1, las mezclas racémicas diastereoméricas, isomeros opticos, sales farmacéuticamente aceptables, prodrogas o metabolitos biologicamente activos del mismo, los que se seleccionan del grupo compuesto por formulas 1 a 117 en donde R1, R2 y R3 son como se describen en la memoria. Uso de un compuesto de Formula 1 o una sal farmacéuticamente aceptable, prodroga o metabolitos biologicamente activos del mismo, para preparar una composicion de utilidad para inhibir una o más actividades de proteína quinasa en un paciente.A kinase inhibitor compound of Formula 1, the diastereomeric racemic mixtures, optical isomers, pharmaceutically acceptable salts, prodrugs or biologically active metabolites thereof, which are selected from the group consisting of formulas 1 to 117 wherein R1, R2 and R3 are as They are described in memory. Use of a compound of Formula 1 or a pharmaceutically acceptable salt, prodrug or biologically active metabolites thereof, to prepare a useful composition for inhibiting one or more protein kinase activities in a patient.

ARP000104887A 1999-09-17 2000-09-18 QUINASE INHIBITOR COMPOUND AND USE OF IT TO PREPARE A PHARMACEUTICAL COMPOSITION AR029766A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15461899P 1999-09-17 1999-09-17

Publications (1)

Publication Number Publication Date
AR029766A1 true AR029766A1 (en) 2003-07-16

Family

ID=22552056

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104887A AR029766A1 (en) 1999-09-17 2000-09-18 QUINASE INHIBITOR COMPOUND AND USE OF IT TO PREPARE A PHARMACEUTICAL COMPOSITION

Country Status (27)

Country Link
EP (1) EP1268481B1 (en)
JP (1) JP2003509427A (en)
KR (1) KR20020063854A (en)
CN (1) CN1390220A (en)
AR (1) AR029766A1 (en)
AT (1) ATE380814T1 (en)
AU (1) AU7491400A (en)
BG (1) BG106585A (en)
BR (1) BR0014075A (en)
CA (1) CA2385769A1 (en)
CY (1) CY1107886T1 (en)
CZ (1) CZ2002934A3 (en)
DE (1) DE60037455T2 (en)
DK (1) DK1268481T3 (en)
ES (1) ES2299434T3 (en)
HK (1) HK1053831A1 (en)
HU (1) HUP0303363A2 (en)
IL (1) IL148719A0 (en)
MX (1) MXPA02002938A (en)
NO (1) NO20021329L (en)
NZ (1) NZ517759A (en)
PL (1) PL354241A1 (en)
PT (1) PT1268481E (en)
SK (1) SK3792002A3 (en)
TR (1) TR200201506T2 (en)
WO (1) WO2001019828A2 (en)
ZA (1) ZA200202122B (en)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
ES2372028T3 (en) 2000-10-23 2012-01-13 Glaxosmithkline Llc NEW COMPOSITE OF 8H-PIRIDO [2,3-D] PIRIMIDIN-7-ONA, REPLACED FOR THE TREATMENT OF DISEASES MEDIATED BY THE CSBP / P38 QUINASA.
AU2002333524A1 (en) 2001-09-11 2003-03-24 Glaxosmithkline K.K. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
MXPA04007961A (en) * 2002-02-22 2004-11-26 Teijin Ltd Pyrrolopyrimidine derivative.
US7560552B2 (en) 2002-03-21 2009-07-14 Abbott Laboratories Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
US20030225273A1 (en) * 2002-03-21 2003-12-04 Michaelides Michael R. Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
RU2004133811A (en) 2002-04-19 2005-04-20 Смитклайн Бичам Корпорейшн (US) NEW COMPOUNDS
AU2003246972A1 (en) 2002-08-06 2004-02-23 Astrazeneca Ab Condensed pyridines and pyrimidines with tie2 (tek) activity
JP2006528685A (en) * 2003-05-06 2006-12-21 スミスクライン ビーチャム コーポレーション New compounds
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US7129260B2 (en) 2003-06-02 2006-10-31 Abbott Laboratories Isoindolinone kinase inhibitors
US7202363B2 (en) 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
CN1860118A (en) * 2003-07-29 2006-11-08 Irm责任有限公司 Compounds and compositions as protein kinase inhibitors
EP1699800B1 (en) * 2003-12-23 2010-02-10 Novartis AG Bicyclic heterocyclic p-38 kinase inhibitors
TW200530236A (en) * 2004-02-23 2005-09-16 Chugai Pharmaceutical Co Ltd Heteroaryl phenylurea
JP2007538068A (en) * 2004-05-19 2007-12-27 アストラゼネカ アクチボラグ Novel fused heterocycles and their use
FR2871158A1 (en) 2004-06-04 2005-12-09 Aventis Pharma Sa SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
MX2007005120A (en) 2004-10-29 2007-07-16 Abbott Lab Novel kinase inhibitors.
DE102004061288A1 (en) 2004-12-14 2006-06-29 Schering Ag New 3-amino-pyrazolo(3,4b)pyridine derivatives are protein tyrosine kinases inhibitors useful e.g. for treating hyperproliferation of body cells, neurodegenerative disease, blood vessel disease and angiogenic disease
PE20061119A1 (en) 2005-01-19 2006-11-27 Aventis Pharma Sa PYRAZOLO PYRIDINES SUBSTITUTED AS INHIBITORS OF FAK, KDR AND Tie KINASES
US7842809B2 (en) 2005-01-24 2010-11-30 Bayer Schering Pharma Ag Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
PE20100741A1 (en) 2005-03-25 2010-11-25 Glaxo Group Ltd COMPOUNDS DERIVED FROM 3,4-DIHYDROPYRIMIDE [4,5-d] PYRIMIDIN-2 (1H) -ONE AS KINASE INHIBITORS p38
MY145281A (en) 2005-03-25 2012-01-13 Glaxo Group Ltd Novel compounds
JP2008535822A (en) 2005-03-25 2008-09-04 グラクソ グループ リミテッド New compounds
JP2008537937A (en) 2005-03-25 2008-10-02 グラクソ グループ リミテッド Process for producing pyrido [2,3-d] pyrimidin-7-one and 3,4-dihydropyrimido [4,5-d] pyrimidin-2 (1H) -one derivatives
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
US7795248B2 (en) 2005-05-18 2010-09-14 Abbott Laboratories, Inc. Substituted 7,8-dihydro-1H-pyrimido[4,5-B][1,4]diazepin-4-amines are novel kinase inhibitors
FR2889526B1 (en) * 2005-08-04 2012-02-17 Aventis Pharma Sa SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
DE102005042742A1 (en) * 2005-09-02 2007-03-08 Schering Ag Substituted imidazo [1,2b] pyridazines as kinase inhibitors, their production and use as pharmaceuticals
TW200800983A (en) * 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
JP2009507924A (en) * 2005-09-14 2009-02-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 5-oxo-5,8-dihydro-pyrido-pyrimidines as c-fms kinase inhibitors
AU2006316605B2 (en) 2005-11-17 2012-04-26 Osi Pharmaceuticals, Inc. Fused bicyclic mTOR inhibitors
WO2007064931A2 (en) * 2005-12-02 2007-06-07 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
PE20070855A1 (en) * 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp DERIVATIVES OF 4-AMINO-PYRROLOTRIAZINE SUBSTITUTE AS KINASE INHIBITORS
EP1981890A2 (en) * 2006-01-25 2008-10-22 OSI Pharmaceuticals, Inc. UNSATURATED mTOR INHIBITORS
DE602007008837D1 (en) * 2006-02-14 2010-10-14 Vertex Pharma AS PROTEIN KINASE INHIBITORS USEFUL DYHYDRODIAZEPINE
US7989459B2 (en) 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US20100234351A1 (en) * 2006-02-23 2010-09-16 Takeda Pharmaceutical Company Limited Fused nitrogen-comprising heterocyclic compound
TW200815437A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
WO2008022060A2 (en) * 2006-08-14 2008-02-21 Novartis Ag Imidazo-pyridine derivatives for modulating protein kinase activity
US7897762B2 (en) * 2006-09-14 2011-03-01 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of proliferative diseases
US7902187B2 (en) 2006-10-04 2011-03-08 Wyeth Llc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
WO2008043019A1 (en) 2006-10-04 2008-04-10 Pharmacopeia, Inc 8-substituted 2-(benzimidazolyl) purine derivatives for immunosuppression
US7919490B2 (en) 2006-10-04 2011-04-05 Wyeth Llc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
WO2008113711A1 (en) 2007-03-22 2008-09-25 F. Hoffmann-La Roche Ag Substituted pyrimidodiazepines useful as plk1 inhibitors
CA2686485A1 (en) 2007-05-23 2008-11-27 Pharmacopeia, Llc Purinones and 1h-imidazopyridinones as pkc-theta inhibitors
DE102007024470A1 (en) 2007-05-24 2008-11-27 Bayer Schering Pharma Aktiengesellschaft New sulfoximine-substituted quinoline and/or quinazoline derivatives are erythropoietin-producing hepatoma amplified sequence-receptor kinase inhibitors useful to prepare medicaments to e.g. treat endometriosis and stenosis
US20110201818A1 (en) 2007-09-25 2011-08-18 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
EP2072502A1 (en) 2007-12-20 2009-06-24 Bayer Schering Pharma Aktiengesellschaft Sulfoximide substituted chinolin and chinazolin derivatives as kinase inhibitors
CN101239978A (en) * 2008-03-05 2008-08-13 南方医科大学 Imidazopyridines compounds
AU2009225434B2 (en) 2008-03-21 2014-05-22 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
JP2011527667A (en) 2008-06-18 2011-11-04 武田薬品工業株式会社 Halo-substituted pyrimidodiazepine
CA2743592A1 (en) 2008-12-05 2010-06-10 Abbott Laboratories Thienopyridine kinase inhibitors with improved cyp safety profile
CA2761389A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US8846673B2 (en) 2009-08-11 2014-09-30 Bristol-Myers Squibb Company Azaindazoles as kinase inhibitors and use thereof
NZ599356A (en) 2009-09-25 2013-08-30 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
KR20120096474A (en) 2009-09-25 2012-08-30 버텍스 파마슈티칼스 인코포레이티드 Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
CN102918042B (en) * 2010-02-08 2016-03-09 默沙东有限责任公司 8-methyl isophthalic acid-phenyl imidazole [1,5-a] pyrazine compound
NZ603643A (en) * 2010-05-31 2014-07-25 Ono Pharmaceutical Co Purinone derivative
AU2015202128B2 (en) * 2010-05-31 2015-05-28 Ono Pharmaceutical Co., Ltd. Purinone derivative
DK3689878T3 (en) 2011-07-19 2021-11-08 Merck Sharp & Dohme 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
RU2750538C2 (en) 2011-11-29 2021-06-29 Оно Фармасьютикал Ко., Лтд. Purinone derivative hydrochloride
UY34484A (en) 2011-12-15 2013-07-31 Bayer Ip Gmbh BENZOTIENILO-PIRROLOTRIAZINAS DISUSTITUIDAS AND ITS USES
WO2013087647A1 (en) 2011-12-15 2013-06-20 Bayer Intellectual Property Gmbh Substituted benzothienyl - pyrrolotriazines and uses thereof in the treatment cancer
US8501724B1 (en) * 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
CA2865021C (en) 2012-02-23 2020-06-30 Bayer Intellectual Property Gmbh Substituted benzothienyl-pyrrolotriazines and uses thereof
BR112014029718A2 (en) 2012-05-31 2017-06-27 Pharmascience Inc protein kinase inhibitors
CA2782774A1 (en) 2012-07-06 2014-01-06 Pharmascience Inc. Protein kinase inhibitors
CN103655566B (en) * 2012-09-10 2016-12-21 杨子娇 Compound purposes in the medicine of preparation preventing and treating glaucoma
CN105796569A (en) * 2012-09-10 2016-07-27 杨子娇 Application of compound to preparation of drug for preventing and treating glaucoma
WO2014114185A1 (en) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
WO2014113942A1 (en) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
EP4066841A1 (en) 2013-03-14 2022-10-05 University of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
US9637487B2 (en) * 2013-07-02 2017-05-02 Pharmacyclics Llc Purinone compounds as kinase inhibitors
AU2014306698A1 (en) 2013-08-12 2016-01-28 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CA2833701A1 (en) * 2013-11-19 2015-05-19 Pharmascience Inc. Protein kinase inhibitors
CA2833867A1 (en) 2013-11-21 2015-05-21 Pharmascience Inc. Protein kinase inhibitors
WO2015083008A1 (en) 2013-12-05 2015-06-11 Acerta Pharma B.V. Therapeutic combination of a pi3k inhibitor and a btk inhibitor
US9834554B2 (en) 2013-12-20 2017-12-05 Merck Sharp & Dohme Corp. BTK inhibitors
EP3082809B1 (en) 2013-12-20 2021-01-20 Merck Sharp & Dohme Corp. Btk inhibitors
US10428331B2 (en) 2014-01-16 2019-10-01 Musc Foundation For Research Development Targeted nanocarriers for the administration of immunosuppressive agents
US10272083B2 (en) 2014-01-21 2019-04-30 Acerta Pharma B.V. Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
WO2015146159A1 (en) 2014-03-25 2015-10-01 Ono Pharmaceutical Co., Ltd. Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma
WO2015181633A2 (en) 2014-04-11 2015-12-03 Acerta Pharma B.V. Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase
TW201613644A (en) 2014-06-17 2016-04-16 Acerta Pharma Bv Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, and/or a JAK-2 inhibitor
PL3179991T3 (en) 2014-08-11 2022-02-14 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
WO2016106628A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Btk inhibitors
WO2016106629A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Btk inhibitors
WO2016106623A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Benzamide imidazopyrazine btk inhibitors
WO2016106624A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Tertiary alcohol imidazopyrazine btk inhibitors
WO2016106626A1 (en) 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors
ES2955554T3 (en) 2015-04-09 2023-12-04 Ono Pharmaceutical Co Process to produce a purinone derivative
PT3954690T (en) 2015-07-02 2023-06-06 Acerta Pharma Bv Solid forms and formulations of (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-(pyridin-2-yl)benzamide
CN105130932B (en) * 2015-07-14 2017-06-16 中国科学院微生物研究所 Compound and its purposes in the medicine for preparing PTP1B inhibitor and treatment and/or prevention type II diabetes
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
KR20230111268A (en) 2016-03-28 2023-07-25 인사이트 코포레이션 Pyrrolotriazine compounds as tam inhibitors
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
BR112019004586A2 (en) 2016-09-09 2019-06-11 Incyte Corp pyrazolopyridine derivatives as hpk1 modulators and their uses for cancer treatment
TW201811799A (en) 2016-09-09 2018-04-01 美商英塞特公司 Pyrazolopyrimidine compounds and uses thereof
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
MD3687996T2 (en) 2017-09-27 2022-04-30 Incyte Corp Salts of pyrrolotriazine derivatives useful as tam inhibitors
SG11202007917VA (en) 2018-02-20 2020-09-29 Incyte Corp N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
AR117600A1 (en) 2018-06-29 2021-08-18 Incyte Corp FORMULATIONS OF AN AXL / MER INHIBITOR
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
MA53726A (en) 2018-09-25 2022-05-11 Incyte Corp PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 AND/OR FGFR MODULATORS
EP4010338A1 (en) 2019-08-06 2022-06-15 Incyte Corporation Solid forms of an hpk1 inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU748884B2 (en) * 1997-03-19 2002-06-13 Abbott Gmbh & Co. Kg Pyrrolo(2,3d)pyrimidines and their use as tyrosine kinase inhibitors
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents

Also Published As

Publication number Publication date
ATE380814T1 (en) 2007-12-15
IL148719A0 (en) 2002-09-12
DK1268481T3 (en) 2008-05-05
CN1390220A (en) 2003-01-08
PL354241A1 (en) 2003-12-29
HUP0303363A2 (en) 2004-07-28
NZ517759A (en) 2004-04-30
WO2001019828A3 (en) 2001-10-04
DE60037455T2 (en) 2008-11-27
SK3792002A3 (en) 2003-09-11
ES2299434T3 (en) 2008-06-01
EP1268481B1 (en) 2007-12-12
CA2385769A1 (en) 2001-03-22
JP2003509427A (en) 2003-03-11
NO20021329D0 (en) 2002-03-18
HK1053831A1 (en) 2003-11-07
BG106585A (en) 2003-03-31
CY1107886T1 (en) 2013-06-19
EP1268481A2 (en) 2003-01-02
CZ2002934A3 (en) 2002-07-17
AU7491400A (en) 2001-04-17
MXPA02002938A (en) 2004-12-06
KR20020063854A (en) 2002-08-05
TR200201506T2 (en) 2002-10-21
NO20021329L (en) 2002-05-21
WO2001019828A2 (en) 2001-03-22
PT1268481E (en) 2008-03-19
DE60037455D1 (en) 2008-01-24
BR0014075A (en) 2002-07-16
ZA200202122B (en) 2003-08-27

Similar Documents

Publication Publication Date Title
AR029766A1 (en) QUINASE INHIBITOR COMPOUND AND USE OF IT TO PREPARE A PHARMACEUTICAL COMPOSITION
CO5580767A2 (en) INDAZOL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINES AND PROCEDURES FOR USE
CO5271715A1 (en) 7-AZA-INDOLIN-2-WAVES SUBSTITUTED IN 4 AND ITS USE AS PROTEIUNA QUINASA INHIBITORS
DK1263730T3 (en) Amine derivatives for the treatment of apoptosis
CO4810375A1 (en) DERIVATIVES OF 9-AMINO-3-KETO Erythromycin
ECSP045483A (en) DERIVATIVES OF BENZOCONDENSED HETEROARILAMIDE OF USEFUL TIENOPIRIDINS AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR USE
AR032136A1 (en) USEFUL ESPIROHETEROCICLIC COMPOUNDS AS REVERSIBLE CISTEINE-PROTEASES INHIBITORS
AR029634A1 (en) USEFUL HETEROCICLIC DERIVATIVE COMPOUNDS AS ANTI-TARGET AGENTS, PHARMACEUTICAL COMPOSITION AND PROCESSING PROCEDURE
UY27226A1 (en) PIRAZOLOPIRIMIDINAS AS THERAPEUTIC AGENTS
UY27222A1 (en) PIRAZOLOPIRIMIDINAS AS THERAPEUTIC AGENTS
AR008164A1 (en) CETOLIDES 6-0-SUBSTITUTES THAT HAVE ANTIBACTERIAL ACTIVITY, PROCEDURES FOR THEIR PREPARATION, USE OF THE SAME IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL COMPOSITIONS
CR6643A (en) NEW BENZOIMIDAZOL DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS
PA8591701A1 (en) PIRROLOPIRIMIDINE DERIVATIVES
AR030933A1 (en) TRIAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR008377A1 (en) A COMPOUND DERIVED FROM 3-AROYLBENCIL-PIRIDAZINONE, A PARTICULAR PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY OR AUTOIMMUNE DISEASES CONTAINING SUCH A COMPOUND
ECSP045004A (en) INHIBITORS OF THE 17BETA-HYDROXIESTEROID DEHYDROGENASE TYPE 3 FOR THE TREATMENT OF DEPENDING ANDROGEN DISEASES
TR200201505T2 (en) Pirazolopyrimidines as therapeutic agents
ECSP066383A (en) DERIVATIVES OF 5-PHENYL-4-METHYL-TIAZOL-2-IL-AMINA AS INHIBITORS OF KINASA ENZYMES PHOSFATIDILINOSITOL 3 (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY ROUTES
UY27350A1 (en) AZAINDOLS
UY26968A1 (en) THERAPEUTIC AGENTS
UY28671A1 (en) PIRIDO (2.3-D) PIRIMIDINA-2,4-DIAMINAS AS PDE 2 INHIBITORS
PA8495101A1 (en) DERIVATIVES OF 13-METHYLERITROMYCIN
NO20025641D0 (en) Substituted 1-aminoalkyl lactams and their use as muscarinic receptor antagonists
NO20025640D0 (en) Substituted 1-aminoalkyl lactams and their use as muscarinic receptor antagonists
UY27803A1 (en) DERIVATIVES OF BENZOXAZINE AND USES OF THE SAME.

Legal Events

Date Code Title Description
FB Suspension of granting procedure