AR029361A1 - GUANIDINE COMPOUNDS ANTAGONIST CYCLES OF THE RECEIVERS OF IL-8, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents
GUANIDINE COMPOUNDS ANTAGONIST CYCLES OF THE RECEIVERS OF IL-8, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCTInfo
- Publication number
- AR029361A1 AR029361A1 ARP000102556A ARP000102556A AR029361A1 AR 029361 A1 AR029361 A1 AR 029361A1 AR P000102556 A ARP000102556 A AR P000102556A AR P000102556 A ARP000102556 A AR P000102556A AR 029361 A1 AR029361 A1 AR 029361A1
- Authority
- AR
- Argentina
- Prior art keywords
- manufacture
- pharmaceutical composition
- receivers
- cycles
- guanidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso de las fenilureas en el tratamiento de enfermedades mediadas por la quimoquina, interleuquina-8 (IL-8). Compuestos de guanidina cíclica antagonistas de los receptores de la IL-8 que comprende la formula (1) en donde R, R1, R2, Y, m y n tienen los significados dados en la descripcion; además se describen la composicion farmacéutica que los comprende y el uso de los mismos para la manufactura de un medicamento para tratar una enfermedad mediada por una quimoquina donde la quimoquina se une a un receptor alfa o beta de la IL-8 en un mamífero.Use of phenylureas in the treatment of diseases mediated by chemokine, interleukin-8 (IL-8). Cyclic guanidine compounds antagonists of IL-8 receptors comprising formula (1) wherein R, R1, R2, Y, m and n have the meanings given in the description; In addition, the pharmaceutical composition comprising them and the use thereof for the manufacture of a medicament for treating a disease mediated by a chemokine where the chemokine binds to an alpha or beta receptor of IL-8 in a mammal are described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13666599P | 1999-05-28 | 1999-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029361A1 true AR029361A1 (en) | 2003-06-25 |
Family
ID=22473833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000102556A AR029361A1 (en) | 1999-05-28 | 2000-05-24 | GUANIDINE COMPOUNDS ANTAGONIST CYCLES OF THE RECEIVERS OF IL-8, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1180025A4 (en) |
JP (1) | JP2003500443A (en) |
KR (1) | KR20020016806A (en) |
CN (1) | CN1352554A (en) |
AR (1) | AR029361A1 (en) |
AU (1) | AU766999B2 (en) |
BR (1) | BR0010863A (en) |
CA (1) | CA2374295A1 (en) |
CO (1) | CO5170528A1 (en) |
CZ (1) | CZ20014246A3 (en) |
HK (1) | HK1045256A1 (en) |
HU (1) | HUP0201302A3 (en) |
IL (1) | IL146053A0 (en) |
MX (1) | MXPA01012267A (en) |
NO (1) | NO20015774D0 (en) |
NZ (1) | NZ514728A (en) |
PL (1) | PL351947A1 (en) |
TR (1) | TR200103354T2 (en) |
WO (1) | WO2000072840A1 (en) |
ZA (1) | ZA200109627B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1413302A3 (en) * | 1999-07-21 | 2004-05-12 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines for the treatment of pain |
US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
AU6230300A (en) * | 1999-07-21 | 2001-02-13 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines and the use thereof |
WO2002070467A1 (en) | 2001-02-26 | 2002-09-12 | 4Sc Ag | Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments |
DE10109204A1 (en) * | 2001-02-26 | 2002-09-19 | 4Sc Ag | Use of new and known diphenylurea compounds for the preparation of a medicament for the inhibition of intracellular protein-degradation pathway |
CA2522817A1 (en) | 2003-05-01 | 2004-11-11 | F. Hoffmann-La Roche Ag | Imidazolin-2-ylaminophenyl amides as ip antagonists |
CN101531621B (en) * | 2009-04-14 | 2012-08-15 | 厦门康奥克科技有限公司 | Method for preparing guanidine compound |
JP2021501198A (en) * | 2017-10-27 | 2021-01-14 | トランスフュージョン ヘルス,リミティド ライアビリティ カンパニー | Compositions and Methods for Proliferating Hematopoietic Stem Cells Using Fluorene Derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US605977A (en) * | 1898-06-21 | Bruno richard seifert | ||
US1953494A (en) * | 1926-08-26 | 1934-04-03 | Ig Farbenindustrie Ag | Process of preparing substituted guanidines |
US3914306A (en) * | 1972-09-22 | 1975-10-21 | Rorer Inc William H | Guanidines |
US5696290A (en) * | 1994-09-12 | 1997-12-09 | Monsanto Company | Synthesis of penta-substituted guanidines |
EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | Il-8 receptor antagonists |
AR008290A1 (en) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | NEW COMPOUNDS CONTAINING GUANIDINE USEFUL AS ANTAGONISTS OF IL-8 RECEPTORS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND PROCEDURE FOR THE PREPARATION OF INTERMEDIARIES. |
WO2000072800A2 (en) * | 1999-05-28 | 2000-12-07 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
UY26627A1 (en) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
-
2000
- 2000-05-24 CO CO00038191A patent/CO5170528A1/en not_active Application Discontinuation
- 2000-05-24 AR ARP000102556A patent/AR029361A1/en unknown
- 2000-05-26 WO PCT/US2000/014660 patent/WO2000072840A1/en not_active Application Discontinuation
- 2000-05-26 AU AU51690/00A patent/AU766999B2/en not_active Ceased
- 2000-05-26 CN CN00808133A patent/CN1352554A/en active Pending
- 2000-05-26 PL PL00351947A patent/PL351947A1/en not_active Application Discontinuation
- 2000-05-26 IL IL14605300A patent/IL146053A0/en unknown
- 2000-05-26 BR BR0010863-4A patent/BR0010863A/en not_active IP Right Cessation
- 2000-05-26 HU HU0201302A patent/HUP0201302A3/en unknown
- 2000-05-26 JP JP2000620952A patent/JP2003500443A/en not_active Withdrawn
- 2000-05-26 MX MXPA01012267A patent/MXPA01012267A/en unknown
- 2000-05-26 TR TR2001/03354T patent/TR200103354T2/en unknown
- 2000-05-26 EP EP00936368A patent/EP1180025A4/en not_active Withdrawn
- 2000-05-26 KR KR1020017015176A patent/KR20020016806A/en not_active Application Discontinuation
- 2000-05-26 NZ NZ514728A patent/NZ514728A/en not_active Application Discontinuation
- 2000-05-26 CA CA002374295A patent/CA2374295A1/en not_active Abandoned
- 2000-05-26 CZ CZ20014246A patent/CZ20014246A3/en unknown
-
2001
- 2001-11-22 ZA ZA200109267A patent/ZA200109627B/en unknown
- 2001-11-27 NO NO20015774A patent/NO20015774D0/en not_active Application Discontinuation
-
2002
- 2002-07-18 HK HK02105335.1A patent/HK1045256A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR200103354T2 (en) | 2002-06-21 |
AU5169000A (en) | 2000-12-18 |
WO2000072840A1 (en) | 2000-12-07 |
KR20020016806A (en) | 2002-03-06 |
NO20015774L (en) | 2001-11-27 |
JP2003500443A (en) | 2003-01-07 |
CZ20014246A3 (en) | 2002-05-15 |
NO20015774D0 (en) | 2001-11-27 |
ZA200109627B (en) | 2002-11-28 |
HK1045256A1 (en) | 2002-11-22 |
CA2374295A1 (en) | 2000-12-07 |
HUP0201302A2 (en) | 2002-12-28 |
PL351947A1 (en) | 2003-07-14 |
HUP0201302A3 (en) | 2003-02-28 |
CO5170528A1 (en) | 2002-06-27 |
IL146053A0 (en) | 2002-07-25 |
BR0010863A (en) | 2002-02-19 |
EP1180025A4 (en) | 2002-08-28 |
NZ514728A (en) | 2004-04-30 |
EP1180025A1 (en) | 2002-02-20 |
AU766999B2 (en) | 2003-10-30 |
MXPA01012267A (en) | 2002-07-30 |
CN1352554A (en) | 2002-06-05 |
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