AR029353A1 - A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION - Google Patents

A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION

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Publication number
AR029353A1
AR029353A1 ARP000101732A ARP000101732A AR029353A1 AR 029353 A1 AR029353 A1 AR 029353A1 AR P000101732 A ARP000101732 A AR P000101732A AR P000101732 A ARP000101732 A AR P000101732A AR 029353 A1 AR029353 A1 AR 029353A1
Authority
AR
Argentina
Prior art keywords
hydrogen
composition
manufacture
therapy
pharmaceutical composition
Prior art date
Application number
ARP000101732A
Other languages
Spanish (es)
Inventor
Jon Mark Bentley
James Edward Paul Davidson
Matthew Alexander Jame Duncton
Richard Hugh Philip Porter
David Reginald Adams
Original Assignee
Vernalis Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Res Ltd filed Critical Vernalis Res Ltd
Priority to ARP000101732A priority Critical patent/AR029353A1/en
Publication of AR029353A1 publication Critical patent/AR029353A1/en

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Abstract

Un compuesto derivado de pirazinoindol de la formula (1) para su uso en terapia, en la cual: R1 a R3 se seleccionan en forma independiente entre hidrogeno y alquilo inferior; X1 se selecciona entre N y C-R4; X2 se selecciona entre N y C-R5; X3 se selecciona entre N y C-R6; X4 se selecciona entre N y C-R7; R4, R5, y R7 se seleccionan en forma independiente entre: hidrogeno, halogeno, hidroxi, alquilo, arilo, alcoxi, ariloxi, alcoilo, ariloilo, alquiltio, ariltio, alquilsulfoxilo, arilsulfoxilo, alquilsulfonilo, arilsulfonilo, amino, alquilamino, dialquilamino, nitro, ciano, carboalcoxi, carboariloxi, y carboxi; y R6 se selecciona entre hidrogeno, halogeno, alquilo, arilo, ariloxi, alquiltio, ariltio, alquilsulfoxilo, arilsulfoxilo, alquilsulfonilo, arilsulfonilo, amino, alquilamino, dialquilamino y ciano; con la condicion de que no todos los R4 a R7 se seleccionen como hidrogeno, y las sales farmacéuticamente aceptables y los compuestos de adicion y profármacos del mismo; su utilizacion en terapia, en particular, para el tratamiento de: los trastornos del sistema nervioso central; los trastornos cardiovasculares, los trastornos gastrointestinales; la diabetes insípida; y la apnea del sueno; y en especial, para el tratamiento de terapia. También se divulga una composicion farmacéutica que lo comprende y un método para la fabricacion de dicha composicion.A pyrazinoindole-derived compound of the formula (1) for use in therapy, in which: R1 to R3 are independently selected from hydrogen and lower alkyl; X1 is selected from N and C-R4; X2 is selected from N and C-R5; X3 is selected from N and C-R6; X4 is selected from N and C-R7; R4, R5, and R7 are independently selected from: hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkoxy, aryloyl, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino, nitro , cyano, carboalkoxy, carboaryloxy, and carboxy; and R6 is selected from hydrogen, halogen, alkyl, aryl, aryloxy, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino and cyano; with the proviso that not all R4 to R7 are selected as hydrogen, and pharmaceutically acceptable salts and addition compounds and prodrugs thereof; its use in therapy, in particular, for the treatment of: disorders of the central nervous system; cardiovascular disorders, gastrointestinal disorders; diabetes insipidus; and sleep apnea; and especially for the therapy treatment. A pharmaceutical composition comprising it and a method for the manufacture of said composition are also disclosed.

ARP000101732A 2000-04-13 2000-04-13 A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION AR029353A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP000101732A AR029353A1 (en) 2000-04-13 2000-04-13 A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP000101732A AR029353A1 (en) 2000-04-13 2000-04-13 A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION

Publications (1)

Publication Number Publication Date
AR029353A1 true AR029353A1 (en) 2003-06-25

Family

ID=37515705

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101732A AR029353A1 (en) 2000-04-13 2000-04-13 A COMPOUND DERIVED FROM PIRAZINOINDOL, USE OF THE SAME, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND A METHOD FOR THE MANUFACTURE OF SUCH COMPOSITION

Country Status (1)

Country Link
AR (1) AR029353A1 (en)

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