AR028960A1 - READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEIN - Google Patents
READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEINInfo
- Publication number
- AR028960A1 AR028960A1 ARP010102892A AR028960A1 AR 028960 A1 AR028960 A1 AR 028960A1 AR P010102892 A ARP010102892 A AR P010102892A AR 028960 A1 AR028960 A1 AR 028960A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- inhibitors
- reading
- replaced
- beta protein
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invencion se relaciona con nuevas lactamas que tienen la formula (1) con composiciones farmacéuticas y con métodos para el uso de las mismas. Estos nuevos compuestos inhiben el procesamiento de la proteína precursora amiloide y más específicamente, inhiben la produccion del péptido Ab, actuando así para prevenir la formacion de depositos neurologicos de proteína amiloide. Más particularmente, la presente invencion se relaciona con el tratamiento de afecciones neurologicas relacionadas con la produccion de beta-amiloides, tales como la enfermedad de Alzheimer, y el síndrome de Down. Los sustituyentes Q, R3, R3a, R5, R5a, R6, anillo B, N, X, Y y Z están definidos en la memoria descriptiva.The invention relates to new lactams having the formula (1) with pharmaceutical compositions and with methods for their use. These new compounds inhibit the processing of the amyloid precursor protein and more specifically, inhibit the production of the Ab peptide, thus acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological conditions related to the production of beta-amyloids, such as Alzheimer's disease, and Down syndrome. The substituents Q, R3, R3a, R5, R5a, R6, ring B, N, X, Y and Z are defined in the specification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP010102892 AR028960A1 (en) | 2001-06-15 | 2001-06-15 | READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEIN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP010102892 AR028960A1 (en) | 2001-06-15 | 2001-06-15 | READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028960A1 true AR028960A1 (en) | 2003-05-28 |
Family
ID=37515632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102892 AR028960A1 (en) | 2001-06-15 | 2001-06-15 | READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEIN |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR028960A1 (en) |
-
2001
- 2001-06-15 AR ARP010102892 patent/AR028960A1/en unknown
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| AR028960A1 (en) | READING REPLACED WITH CYCLIC SUCCINATES AS INHIBITORS OF THE PRODUCTION OF BETA PROTEIN |