AR027556A1 - DERIVATIVES OF POLIFLUOROALQUILIMIDAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS - Google Patents

DERIVATIVES OF POLIFLUOROALQUILIMIDAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS

Info

Publication number
AR027556A1
AR027556A1 ARP010100874A ARP010100874A AR027556A1 AR 027556 A1 AR027556 A1 AR 027556A1 AR P010100874 A ARP010100874 A AR P010100874A AR P010100874 A ARP010100874 A AR P010100874A AR 027556 A1 AR027556 A1 AR 027556A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
2alkyl
hydroxy
phenyl
Prior art date
Application number
ARP010100874A
Other languages
Spanish (es)
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of AR027556A1 publication Critical patent/AR027556A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de formula general (1): en la cual R1 es un grupo de formula CnHxFy o n= 1 o 2, x= 0 a 3, y = 1 a 5 y x+y=2n+1 y R2 representa un hidrogeno, ungrupo C1+4 alquilo o un átomo de hidrogeno, R representa un grupo C2-4 alquenilo, fenilo, naftil o, tienilo, furilo, pirrolilo, piridilo, imidazolilo otiazolilo, sustituido eventualmente por uno, dos o tres grupos R4; R3, presente uno, dos o tres veces sobre el fenilo y R4 representan, independientementeentre sí, un átomo de hidrogeno, un átomo de halogeno, un grupo C1-4, alquilo, hidroxi, C1-4 alquilo, hidroxi,, C1-4, alcoxi, ciano, nitro, perfluoro C1-2alquilo, amino, O-(C1-2alquilo)-NH2, SO2NH2 o hidroximetilo, así como sus sales, N-oxidos e hidratos.Compounds of general formula (1): in which R1 is a group of formula CnHxFy on = 1 or 2, x = 0 to 3, y = 1 to 5 and x + y = 2n + 1 and R2 represents a hydrogen, a group C1 + 4 alkyl or a hydrogen atom, R represents a C2-4 alkenyl, phenyl, naphthyl or, thienyl, furyl, pyrrolyl, pyridyl, imidazolyl otiazolyl group, optionally substituted by one, two or three R4 groups; R3, present one, two or three times on the phenyl and R4 independently represent, among themselves, a hydrogen atom, a halogen atom, a C1-4 group, alkyl, hydroxy, C1-4 alkyl, hydroxy ,, C1-4 , alkoxy, cyano, nitro, perfluoro C1-2alkyl, amino, O- (C1-2alkyl) -NH2, SO2NH2 or hydroxymethyl, as well as their salts, N-oxides and hydrates.

ARP010100874A 2000-03-01 2001-02-27 DERIVATIVES OF POLIFLUOROALQUILIMIDAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS AR027556A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0002596A FR2805815B1 (en) 2000-03-01 2000-03-01 POLYFLUOROALKYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR027556A1 true AR027556A1 (en) 2003-04-02

Family

ID=8847574

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100874A AR027556A1 (en) 2000-03-01 2001-02-27 DERIVATIVES OF POLIFLUOROALQUILIMIDAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS

Country Status (4)

Country Link
AR (1) AR027556A1 (en)
AU (1) AU2001237518A1 (en)
FR (1) FR2805815B1 (en)
WO (1) WO2001064631A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005254800B2 (en) 2004-06-15 2010-12-09 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
CL2008003120A1 (en) 2007-11-01 2009-10-09 Acucela Inc Compounds derived from phenylalkyl-, phenylalkenyl-, phenylalkynyl amine, phenylthioalkylamine, phenylaminoalkylamine, phenylalkoxyamine and phenylalkylguanidine; pharmaceutical composition; and use of the compounds to treat an ophthalmological disorder or disease such as retinopathy, maculopathy, retinitis pigmentosa, uveitis, among others.
GB0901487D0 (en) * 2009-01-30 2009-03-11 Movetis N V Asthma Therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751647B1 (en) * 1996-07-25 1998-09-11 Synthelabo BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS
FR2771093B1 (en) * 1997-11-19 2000-01-21 Synthelabo IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2772378B1 (en) * 1997-12-12 2000-02-04 Synthelabo IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
FR2805815A1 (en) 2001-09-07
WO2001064631A3 (en) 2002-03-28
FR2805815B1 (en) 2002-05-17
WO2001064631A2 (en) 2001-09-07
AU2001237518A1 (en) 2001-09-12

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