AR026300A1 - NEW COMPOUNDS FOR THE TREATMENT OF VASCULAR COMPLICATIONS RELATED TO DIABETES AND AGING, THE PROCESS FOR PREPARATION AND THERAPEUTIC USES. - Google Patents

NEW COMPOUNDS FOR THE TREATMENT OF VASCULAR COMPLICATIONS RELATED TO DIABETES AND AGING, THE PROCESS FOR PREPARATION AND THERAPEUTIC USES.

Info

Publication number
AR026300A1
AR026300A1 ARP000105723A ARP000105723A AR026300A1 AR 026300 A1 AR026300 A1 AR 026300A1 AR P000105723 A ARP000105723 A AR P000105723A AR P000105723 A ARP000105723 A AR P000105723A AR 026300 A1 AR026300 A1 AR 026300A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
different
heteroaryl
aryl
Prior art date
Application number
ARP000105723A
Other languages
Spanish (es)
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of AR026300A1 publication Critical patent/AR026300A1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Describe compuestos nuevos de la serie piridinio utiles para el tratamietno de las complicaciones vasculares por diabetes y relacionadas con elenvejecimiento, incluyento a las enfermedades del rion en nervios, aterosclerosis, retinopatías, trastornos dermatologicos y decoloracion de los dientes, laruptura el AGE pre formado, de la formula general 1, o sus sales faramcéuticamente aceptables, donde R1 es -R4-R5 o -N(R7)N(R7)R9; R4 se selecciona del grupoformado por -N(R7)R6O-, -N(R7)R6N(R7)-, OR6O , y -OR6N(R7)-, donde R6 es alquilo; R5 se selecciona del grupo formado por alquilo, arilo incluyendo heteroarilo,-COR7, SO2 R7; -C(S)NHR7, -C(NH)MHR7, -COR10, -C(O)NHR7 y -N(R7)N=CR7R10 donde R7 se selecciona del grupo formado por H, alquilo y arilo incluyendo heteroarilosi R7 fuera diferente para R1 y R3 en el mismo compuesto; R2 se selecciona del grupo formado por H, alquilo ya rilo incluyendo heteroarilo si R7 fueradiferente para R1 y R3 en el mismo compuesto; R2 se selecciona del grupo form ado por F, CL, Br, I, OR7, NO2, alquilo,a rilo incluyendo heteroarilo, formilo,acilo, C(O)NR7R10, C(I)OR7, NR7R10, N=C(R7)(R10), SR7, SO2NH2, SO2 alquilo y SO2 arilo, y m es 0, 1 o 2; R3 se selecciona del grupo formado por R7, OR7, N(R7)(R10), N=C(R7 )(R10), N(R7)N(R7)(R10), N(R7) N=C(R7)(R10) y CH(R7)C(O)R8 donde R8 se selecciona del grupo formado por R7, OR7 y NR7R10; R9 se selecciona delgrupo formado por hidrogeno, alquilo,a rilo incluyendo heteroarilo, C(O)R10, -SO2R10, -C(S)NHR10, -C(NH)NH(R 10) y -C(O)NHR10, R10 se selecciona del grupoformado por H, alquilo o arilo incluyendo heteroarilo y en cada caso, es opcionalmente diferente del sustituyente R10, si R10 fuera diferente de R1 y R3 en elmismo compuesto; X se selecciona del grupo for mado por un ion de haluro, acetato, perclorato, sulfonato, oxalato, citrato, tosilato, amleato, mesilato,carbonato, sulfito, hidrogeno fosforico, fosfonato, fosfato, BF4- y PF6; con la condicion de que, (i)cuando dos grupos alquilo están presentes en el mismocarobno o nitrogeno, están enlazados opcionalmente para formar una estructura cíclica y (ii)el nitrogeno del anillo heteroarilo de R10, cuando está presente,It describes new compounds of the pyridinium series useful for the treatment of vascular complications due to diabetes and related to aging, including diseases of the kidney in nerves, atherosclerosis, retinopathies, dermatological disorders and discoloration of teeth, larupture of pre-formed AGE, of the general formula 1, or its pharmaceutically acceptable salts, wherein R1 is -R4-R5 or -N (R7) N (R7) R9; R4 is selected from the group formed by -N (R7) R6O-, -N (R7) R6N (R7) -, OR6O, and -OR6N (R7) -, where R6 is alkyl; R5 is selected from the group consisting of alkyl, aryl including heteroaryl, -COR7, SO2 R7; -C (S) NHR7, -C (NH) MHR7, -COR10, -C (O) NHR7 and -N (R7) N = CR7R10 where R7 is selected from the group consisting of H, alkyl and aryl including heteroarylsi R7 is different for R1 and R3 in the same compound; R2 is selected from the group consisting of H, alkyl and ryl including heteroaryl if R7 is different for R1 and R3 in the same compound; R2 is selected from the group consisting of F, CL, Br, I, OR7, NO2, alkyl, a ryl including heteroaryl, formyl, acyl, C (O) NR7R10, C (I) OR7, NR7R10, N = C (R7 ) (R10), SR7, SO2NH2, SO2 alkyl and SO2 aryl, and m is 0, 1 or 2; R3 is selected from the group consisting of R7, OR7, N (R7) (R10), N = C (R7) (R10), N (R7) N (R7) (R10), N (R7) N = C (R7 ) (R10) and CH (R7) C (O) R8 where R8 is selected from the group consisting of R7, OR7 and NR7R10; R9 is selected from the group consisting of hydrogen, alkyl, a ryl including heteroaryl, C (O) R10, -SO2R10, -C (S) NHR10, -C (NH) NH (R 10) and -C (O) NHR10, R10 it is selected from the group formed by H, alkyl or aryl including heteroaryl and in each case, is optionally different from the substituent R10, if R10 is different from R1 and R3 in the same compound; X is selected from the group formed by a halide, acetate, perchlorate, sulfonate, oxalate, citrate, tosylate, aminate, mesylate, carbonate, sulphite, phosphoric hydrogen, phosphonate, phosphate, BF4- and PF6 ion; with the proviso that, (i) when two alkyl groups are present in the same carbon or nitrogen, they are optionally linked to form a cyclic structure and (ii) the nitrogen of the heteroaryl ring of R10, when present,

ARP000105723A 1996-02-20 2000-10-30 NEW COMPOUNDS FOR THE TREATMENT OF VASCULAR COMPLICATIONS RELATED TO DIABETES AND AGING, THE PROCESS FOR PREPARATION AND THERAPEUTIC USES. AR026300A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1197496P 1996-02-20 1996-02-20

Publications (1)

Publication Number Publication Date
AR026300A1 true AR026300A1 (en) 2003-02-05

Family

ID=21752774

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP970100681A AR005929A1 (en) 1996-02-20 1997-02-20 METHOD FOR THE PREPARATION OF DIFENIL ISOXAZOLIL SULFONAMIDAS AND INTERMEDIATE COMPOUNDS FOR APPLICATION IN SUCH METHODS.
ARP000105723A AR026300A1 (en) 1996-02-20 2000-10-30 NEW COMPOUNDS FOR THE TREATMENT OF VASCULAR COMPLICATIONS RELATED TO DIABETES AND AGING, THE PROCESS FOR PREPARATION AND THERAPEUTIC USES.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP970100681A AR005929A1 (en) 1996-02-20 1997-02-20 METHOD FOR THE PREPARATION OF DIFENIL ISOXAZOLIL SULFONAMIDAS AND INTERMEDIATE COMPOUNDS FOR APPLICATION IN SUCH METHODS.

Country Status (4)

Country Link
AR (2) AR005929A1 (en)
RU (1) RU2209815C2 (en)
TW (1) TW402597B (en)
ZA (1) ZA971289B (en)

Also Published As

Publication number Publication date
RU2209815C2 (en) 2003-08-10
TW402597B (en) 2000-08-21
AR005929A1 (en) 1999-07-21
ZA971289B (en) 1998-08-25

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