AR026267A1 - CYTOTOXIC HETEROCICLIC AGENTS. - Google Patents
CYTOTOXIC HETEROCICLIC AGENTS.Info
- Publication number
- AR026267A1 AR026267A1 ARP000105664A ARP000105664A AR026267A1 AR 026267 A1 AR026267 A1 AR 026267A1 AR P000105664 A ARP000105664 A AR P000105664A AR P000105664 A ARP000105664 A AR P000105664A AR 026267 A1 AR026267 A1 AR 026267A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- heterociclic
- cytotoxic
- agents
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Proporciona compuestos de formula 1 donde R1-R8 A-G tiene cualquier de los significados significados definidos en la especificacion, y sus salesfarmacéuticamente aceptables. También proporciona composiciones farmacéuticas que incluyen un compuesto de formula 1, procesos para preparar compuestos deformula 1, intermediarios utiles para preparar compuestos de formula a y métodos terapéuticos para tratar cáncer usando compuestos de formula 1.It provides compounds of formula 1 where R1-R8 A-G has any of the meanings defined in the specification, and their pharmaceutically acceptable salts. It also provides pharmaceutical compositions that include a compound of formula 1, processes for preparing compounds of formula 1, intermediates useful for preparing compounds of formula a and therapeutic methods for treating cancer using compounds of formula 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16254099P | 1999-10-29 | 1999-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR026267A1 true AR026267A1 (en) | 2003-02-05 |
Family
ID=22586069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105664A AR026267A1 (en) | 1999-10-29 | 2000-10-27 | CYTOTOXIC HETEROCICLIC AGENTS. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1228045A2 (en) |
JP (1) | JP2003513079A (en) |
AR (1) | AR026267A1 (en) |
AU (1) | AU1236401A (en) |
CA (1) | CA2389312A1 (en) |
WO (1) | WO2001032631A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2311639T3 (en) | 2001-11-14 | 2009-02-16 | Rutgers, The State University | CYTOTOXIC AGENTS. |
WO2003051289A2 (en) * | 2001-11-14 | 2003-06-26 | Rutgers, The State University | Solubilized topoisomerase poison agents |
AU2002364953A1 (en) | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
SI1465625T1 (en) | 2001-11-14 | 2010-06-30 | Univ Rutgers | Solubilized topoisomerase poisons |
AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
AU2003265406A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
WO2004014862A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
AU2003290818A1 (en) | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
AU2003292625B2 (en) * | 2002-12-26 | 2008-07-24 | Eisai R & D Management Co., Ltd. | Selective estrogen receptor modulators |
DE102008022221A1 (en) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitors of human aldosterone synthase CYP11B2 |
TW201038578A (en) | 2009-01-30 | 2010-11-01 | Univ Rutgers | Methods to treat cancer |
WO2010102219A1 (en) | 2009-03-06 | 2010-09-10 | Rutgers, The State University Of New Jersey | Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
DK3122426T3 (en) | 2014-03-28 | 2023-04-03 | Univ Duke | Treatment of breast cancer using selective estrogen receptor modulators |
WO2017176648A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045272A1 (en) * | 1997-04-07 | 1998-10-15 | Latrobe University | Topoisomerase inhibitors |
-
2000
- 2000-10-26 WO PCT/US2000/029583 patent/WO2001032631A2/en not_active Application Discontinuation
- 2000-10-26 AU AU12364/01A patent/AU1236401A/en not_active Abandoned
- 2000-10-26 CA CA002389312A patent/CA2389312A1/en not_active Abandoned
- 2000-10-26 JP JP2001534782A patent/JP2003513079A/en not_active Withdrawn
- 2000-10-26 EP EP00973917A patent/EP1228045A2/en not_active Withdrawn
- 2000-10-27 AR ARP000105664A patent/AR026267A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001032631A2 (en) | 2001-05-10 |
CA2389312A1 (en) | 2001-05-10 |
AU1236401A (en) | 2001-05-14 |
WO2001032631A3 (en) | 2002-02-21 |
JP2003513079A (en) | 2003-04-08 |
EP1228045A2 (en) | 2002-08-07 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |