AR021818A1 - PRODUCTION OF SOLUBLE RECOMBINANT TRIPSYNOGEN ANALOGS - Google Patents
PRODUCTION OF SOLUBLE RECOMBINANT TRIPSYNOGEN ANALOGSInfo
- Publication number
- AR021818A1 AR021818A1 ARP990104729A ARP990104729A AR021818A1 AR 021818 A1 AR021818 A1 AR 021818A1 AR P990104729 A ARP990104729 A AR P990104729A AR P990104729 A ARP990104729 A AR P990104729A AR 021818 A1 AR021818 A1 AR 021818A1
- Authority
- AR
- Argentina
- Prior art keywords
- analogs
- trypsinogen
- trypsin
- tripsynogen
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a los análogos de tripsinogeno y tripsina producidos en forma recombinante, incluyendo a los ácidos nucleicos quecodifican a los análogos de tripsinogeno y tripsina. Los análogos de tripsinogeno de la presente invencion contienen modificaciones de la secuencia líder detripsinogeno de forma tal que el tripsinogeno no puede ser clivado por las tripsina o enzimas tipo tripsina. La presente invencion también incluye los procesospara producir análogos de tripsinogenorecombinante que pueden ser subsecuentemente activado.The present invention relates to recombinantly produced trypsinogen and trypsin analogs, including nucleic acids that encode trypsinogen and trypsin analogs. The trypsinogen analogs of the present invention contain modifications of the detripsinogen leader sequence such that trypsinogen cannot be cleaved by trypsin or trypsin-like enzymes. The present invention also includes processes for producing trypsinogen-like analogs that can be subsequently activated.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10121398P | 1998-09-21 | 1998-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR021818A1 true AR021818A1 (en) | 2002-08-07 |
Family
ID=22283537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990104729A AR021818A1 (en) | 1998-09-21 | 1999-09-20 | PRODUCTION OF SOLUBLE RECOMBINANT TRIPSYNOGEN ANALOGS |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1141263A4 (en) |
AR (1) | AR021818A1 (en) |
AU (1) | AU6388499A (en) |
CA (1) | CA2343966A1 (en) |
PE (1) | PE20001068A1 (en) |
WO (1) | WO2000017332A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7053500A (en) * | 1999-09-15 | 2001-04-17 | Eli Lilly And Company | Chymotrypsin-free trypsin |
US7276605B2 (en) | 2001-02-01 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Method for producing recombinant trypsin |
DE60328802D1 (en) | 2002-08-30 | 2009-09-24 | Novozymes Inc | PROCESS FOR THE PREPARATION OF MAMMALS TRYPSINS |
CN104312933B (en) * | 2014-10-17 | 2017-03-29 | 江南大学 | A kind of method that optimization signal peptide improves the expression of trypsin exocytosiss |
JP2018537976A (en) | 2015-11-25 | 2018-12-27 | アカデミシュ・ジークンホイス・ライデン | Recombinant serine protease |
CN116445462A (en) * | 2023-04-20 | 2023-07-18 | 西安麦博泰克生物科技有限公司 | Purification preparation method of recombinant porcine pepsin and recombinant porcine pepsin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763215A (en) * | 1984-08-16 | 1998-06-09 | Bio-Technology General Corporation | Method of removing N-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby |
TW257792B (en) * | 1992-10-01 | 1995-09-21 | Lilly Co Eli | |
IL107536A0 (en) * | 1992-11-13 | 1994-02-27 | Lilly Co Eli | Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith |
US5773248A (en) * | 1995-11-13 | 1998-06-30 | Uab Research Foundation | Nucleic acid encoding a human α3(IX) collagen protein and method of producing the protein recombinantly |
JPH09294583A (en) * | 1996-03-08 | 1997-11-18 | Ajinomoto Co Inc | Aminopeptidase gx and hydrolysis of protein using the same |
-
1999
- 1999-09-15 CA CA002343966A patent/CA2343966A1/en not_active Abandoned
- 1999-09-15 AU AU63884/99A patent/AU6388499A/en not_active Abandoned
- 1999-09-15 EP EP99951445A patent/EP1141263A4/en not_active Withdrawn
- 1999-09-15 WO PCT/US1999/021047 patent/WO2000017332A1/en not_active Application Discontinuation
- 1999-09-20 AR ARP990104729A patent/AR021818A1/en unknown
- 1999-09-20 PE PE1999000952A patent/PE20001068A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1141263A1 (en) | 2001-10-10 |
EP1141263A4 (en) | 2002-08-28 |
CA2343966A1 (en) | 2000-03-30 |
PE20001068A1 (en) | 2000-10-18 |
AU6388499A (en) | 2000-04-10 |
WO2000017332A1 (en) | 2000-03-30 |
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