AR021577A1 - PREPARED WITH AN IMPROVED THERAPEUTIC EXTENSION, CONTAINING INHIBITORS OF THE SYNTHESIS OF THE NUCLEOTIDES - Google Patents
PREPARED WITH AN IMPROVED THERAPEUTIC EXTENSION, CONTAINING INHIBITORS OF THE SYNTHESIS OF THE NUCLEOTIDESInfo
- Publication number
- AR021577A1 AR021577A1 ARP990106239A ARP990106239A AR021577A1 AR 021577 A1 AR021577 A1 AR 021577A1 AR P990106239 A ARP990106239 A AR P990106239A AR P990106239 A ARP990106239 A AR P990106239A AR 021577 A1 AR021577 A1 AR 021577A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- nucleotides
- prepared
- improved therapeutic
- inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Preparado con una amplitud terapéutica mejorada, que contiene inhibidores de la síntesis de los nucleotidos. Un preparado que contiene por lo menos uncompuesto que esencialmente impide la circulacion entero-hepática de los inhibidores de la síntesisde los nucleotidos, o que, temporalmente desplazado,antagoniza el efecto de los inhibidores de la síntesis de los nucleotidos, y un inhibidor de la síntesis de los nucleotidos, tal como el Brequinar, elMicofenolatmofetil, el 2-morfolinoetil-(E)-(1,3-dihidro-4-hidroxi-6-metoxi-7-metil-3-oxoisobenzofuran-5-il)-4-metil-4-hexenoato), el Methotrexato, elMizoribine y los compuestos de las formulas (1) o (2): es adecuado para el tratamiento de enfermedades inmunologicas, del cáncer, o en transplantes.Prepared with an improved therapeutic amplitude, which contains inhibitors of nucleotide synthesis. A preparation that contains at least one compound that essentially prevents the interstate circulation of nucleotide synthesis inhibitors, or that, temporarily displaced, antagonizes the effect of nucleotide synthesis inhibitors, and a synthesis inhibitor of nucleotides, such as Brequinar, Mycophenolatemophthyl, 2-morpholinoethyl- (E) - (1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl) -4- methyl-4-hexenoate), Methotrexate, Mizoribine and the compounds of formulas (1) or (2): it is suitable for the treatment of immunological diseases, cancer, or transplants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857009A DE19857009A1 (en) | 1998-12-10 | 1998-12-10 | Preparation with improved therapeutic range, containing nucleotide synthesis inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021577A1 true AR021577A1 (en) | 2002-07-24 |
Family
ID=7890633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106239A AR021577A1 (en) | 1998-12-10 | 1999-12-07 | PREPARED WITH AN IMPROVED THERAPEUTIC EXTENSION, CONTAINING INHIBITORS OF THE SYNTHESIS OF THE NUCLEOTIDES |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1137438B1 (en) |
| JP (1) | JP2002531525A (en) |
| KR (1) | KR20010080729A (en) |
| CN (1) | CN1189214C (en) |
| AR (1) | AR021577A1 (en) |
| AT (1) | ATE218370T1 (en) |
| AU (1) | AU766810B2 (en) |
| BG (1) | BG105548A (en) |
| BR (1) | BR9916006A (en) |
| CA (1) | CA2354266A1 (en) |
| CZ (1) | CZ20012029A3 (en) |
| DE (2) | DE19857009A1 (en) |
| DK (1) | DK1137438T3 (en) |
| EA (1) | EA005136B1 (en) |
| EE (1) | EE200100305A (en) |
| ES (1) | ES2178496T3 (en) |
| HK (1) | HK1041598B (en) |
| HR (1) | HRP20010429A2 (en) |
| HU (1) | HUP0104624A3 (en) |
| IL (1) | IL143586A0 (en) |
| MX (1) | MXPA01005861A (en) |
| NO (1) | NO20012719L (en) |
| NZ (1) | NZ511882A (en) |
| PL (1) | PL349336A1 (en) |
| PT (1) | PT1137438E (en) |
| SI (1) | SI1137438T1 (en) |
| SK (1) | SK284842B6 (en) |
| WO (1) | WO2000033876A1 (en) |
| YU (1) | YU39901A (en) |
| ZA (1) | ZA200104815B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10112924A1 (en) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-butanoic acid derivatives, pharmaceutical compositions containing such derivatives and uses of such derivatives |
| EP1377291A2 (en) * | 2001-03-13 | 2004-01-07 | Protagen AG | 1-butyric acid derivatives such as carbomethoxypropionyl cyanide or leflunomide derivatives, and the therapeutic use thereof |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| WO2004012746A2 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| CA2498045A1 (en) * | 2002-09-06 | 2004-03-25 | Schebo Biotech Ag | Compounds for modulating the glycolosis enzyme complex and/or transaminase complex |
| JPWO2005060980A1 (en) * | 2003-12-24 | 2007-12-13 | 正彬 少名子 | Drugs for treating diseases and drugs for treating diabetes |
| DE102005017592A1 (en) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Dosage forms and combination preparations of pyrimidine biosynthesis inhibitors to achieve additional effects on the immune system |
| BRPI0810202A2 (en) | 2007-05-03 | 2014-10-21 | Pfizer Ltd | PYRIDINE DERIVATIVES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4127737A1 (en) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | MEDICINAL PRODUCTS FOR TREATMENT OF REPELLATION REACTIONS IN ORGAN PLANTING |
| ES2079765T3 (en) * | 1991-10-23 | 1996-01-16 | Hoechst Ag | DERIVATIVES OF N-PHENYL-2-CIANE-3-HYDROXICROTONIC ACID AMIDES AND THEIR USE AS A MEDICINE WITH IMMUNOMODULATING PROPERTY. |
| IT1254519B (en) * | 1992-03-16 | 1995-09-25 | Chiesi Farma Spa | ASSOCIATIONS OF ANTIVIRAL COMPOUNDS |
| DE19539638A1 (en) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | The use of isoxazole and crotonic acid amide derivatives for the treatment of cancer |
| AU4596097A (en) * | 1996-09-26 | 1998-04-17 | Williams, James W. | Improved therapeutic uses of 4-quinoline-carboxylic acid derivatives |
-
1998
- 1998-12-10 DE DE19857009A patent/DE19857009A1/en not_active Withdrawn
-
1999
- 1999-12-01 HU HU0104624A patent/HUP0104624A3/en unknown
- 1999-12-01 IL IL14358699A patent/IL143586A0/en unknown
- 1999-12-01 AU AU17793/00A patent/AU766810B2/en not_active Ceased
- 1999-12-01 CN CNB998142433A patent/CN1189214C/en not_active Expired - Fee Related
- 1999-12-01 WO PCT/EP1999/009380 patent/WO2000033876A1/en not_active Application Discontinuation
- 1999-12-01 SK SK788-2001A patent/SK284842B6/en unknown
- 1999-12-01 KR KR1020017007176A patent/KR20010080729A/en not_active Application Discontinuation
- 1999-12-01 BR BR9916006-4A patent/BR9916006A/en not_active IP Right Cessation
- 1999-12-01 JP JP2000586366A patent/JP2002531525A/en not_active Withdrawn
- 1999-12-01 DK DK99961041T patent/DK1137438T3/en active
- 1999-12-01 EP EP99961041A patent/EP1137438B1/en not_active Expired - Lifetime
- 1999-12-01 NZ NZ511882A patent/NZ511882A/en unknown
- 1999-12-01 CA CA002354266A patent/CA2354266A1/en not_active Abandoned
- 1999-12-01 AT AT99961041T patent/ATE218370T1/en not_active IP Right Cessation
- 1999-12-01 PT PT99961041T patent/PT1137438E/en unknown
- 1999-12-01 EE EEP200100305A patent/EE200100305A/en unknown
- 1999-12-01 MX MXPA01005861A patent/MXPA01005861A/en active IP Right Grant
- 1999-12-01 EA EA200100647A patent/EA005136B1/en not_active IP Right Cessation
- 1999-12-01 SI SI9930063T patent/SI1137438T1/en unknown
- 1999-12-01 CZ CZ20012029A patent/CZ20012029A3/en unknown
- 1999-12-01 YU YU39901A patent/YU39901A/en unknown
- 1999-12-01 PL PL99349336A patent/PL349336A1/en not_active Application Discontinuation
- 1999-12-01 ES ES99961041T patent/ES2178496T3/en not_active Expired - Lifetime
- 1999-12-01 DE DE59901681T patent/DE59901681D1/en not_active Expired - Fee Related
- 1999-12-07 AR ARP990106239A patent/AR021577A1/en not_active Application Discontinuation
-
2001
- 2001-05-30 BG BG105548A patent/BG105548A/en unknown
- 2001-06-01 NO NO20012719A patent/NO20012719L/en not_active Application Discontinuation
- 2001-06-07 HR HR20010429A patent/HRP20010429A2/en not_active Application Discontinuation
- 2001-06-13 ZA ZA200104815A patent/ZA200104815B/en unknown
-
2002
- 2002-05-02 HK HK02103282.9A patent/HK1041598B/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |