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Application filed by Biogal GyogyszergyarfiledCriticalBiogal Gyogyszergyar
Priority to ARP990104897priorityCriticalpatent/AR021224A1/en
Publication of AR021224A1publicationCriticalpatent/AR021224A1/en
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems
(AREA)
Abstract
Procedimiento para la purificacion cromatográfica de ciclosporina A a partir de un producto crudo que contiene un complejo de ciclosporinas,utilizando una columna rellena con silicagel y aplicando una cromatografĂa en etapas multiples en una columnarellena con silicagel de fase normaly una mezcla solvente que contiene tolueno como el principal componente. Ciclosporina A de alta pureza con contenidos de las ciclosporinas L, U yD inferiores a 0,05% p/p y de ciclosporinas B y C inferiores a 0,02%p/p.Procedure for the chromatographic purification of cyclosporin A from a crude product containing a complex of cyclosporins, using a column filled with silica gel and applying a multistage chromatography on a column filled with a silica gel of a normal phase and a solvent mixture containing toluene such as main component. High purity cyclosporin A with contents of cyclosporins L, U and D below 0.05% w / w and cyclosporins B and C below 0.02% w / w.
ARP9901048971999-09-291999-09-29
PROCEDURE FOR PURIFICATION OF HIGH PURITY CYCLOSPORINE A AND HIGH PURITY CYCLOSPORINE.
AR021224A1
(en)
PHARMACEUTICAL COMPOSITIONS CONTAINING IN ASSOCIATION A SELECTIVE ANTAGONIST OF V1ADELAARGININE-VASOPRESSIN RECEPTORS AND A SELECTIVE ANTAGONIST OF V2 RECEPTORS OF ARGININ-VASOPRESIN.