AR020045A1 - A DELTA 5-DESATURASA OF FATTY ACID, ITS USE, AN ISOLATED OIL FROM GUESTS CELLS THAT EXPRESS SUCH DESATURASA, A MICROBIAL OIL OR FRACCIONDEL SAME PRODUCED USING SUCH DESATURASA, AND A NUTRITIONAL FORM A BABY FORMULA , A SUPPLEMENT - Google Patents
A DELTA 5-DESATURASA OF FATTY ACID, ITS USE, AN ISOLATED OIL FROM GUESTS CELLS THAT EXPRESS SUCH DESATURASA, A MICROBIAL OIL OR FRACCIONDEL SAME PRODUCED USING SUCH DESATURASA, AND A NUTRITIONAL FORM A BABY FORMULA , A SUPPLEMENTInfo
- Publication number
- AR020045A1 AR020045A1 ARP980104975A ARP980104975A AR020045A1 AR 020045 A1 AR020045 A1 AR 020045A1 AR P980104975 A ARP980104975 A AR P980104975A AR P980104975 A ARP980104975 A AR P980104975A AR 020045 A1 AR020045 A1 AR 020045A1
- Authority
- AR
- Argentina
- Prior art keywords
- fatty acid
- desaturasa
- delta
- desaturase
- cells
- Prior art date
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se describe una Delta 5 desaturasa de ácido graso capaz de catalizar la conversion del ácido dihomo-gama-linolénico a ácido araquidonico, caracterizadaporque ha sido codificada por una secunecia de nucleotidos aislada que tiene una secuencia denucle otidos seleccionada del grupo que consiste en NO ID SEC:1, 13, 17, 19, 21, 22, 23, 24, 25, 26 y 27; y porque la misma comprende un polipéptido aislado que tiene una secuencia de polipéptidos seleccionada del grupoque consiste en los NO. ID.SEC: 2, 3 , 4, 5, 6, 7, 14, 16, 18, 20, 28, 29, 30, 31, 32, 33, y 34 o un polipéptido que comprende los residuos de los aminoácidos30-38, 41-44, 171-175, 203-212 y 387-394 del NO. ID. SEC: 2, un aceite aislado a partir de células huésped queexpresan la Delta- 5-desaturasa de ácido graso;el uso de la Delta-5-desaturasa de ácidograso en un método para obtener la biosíntesis alterada del ácido graso poliinsaturado de cadena larga, el cualcomprende los pasos de: Cultivar un microbio quetiene células las cual es contienen un transgén que codifica un producto de expresion del transgén que desaturauna molécula de ácido graso en el carbono 5 del extremo del carboxilo de dicha molécula de ácido graso donde el mencionado transgén estáoperativamenteasociado co n una secuencia de control de expresion, en condiciones por las cuales se expresa el citado transgen, por lo que se altera la biosíntesis del ácidograso poliinsaturado de cadena larga en las citadas células; un aceitemicrobiano o una fraccion del mi smo, producido mediante la utilizacion de la Delta-5-desaturasa de ácido graso en el método para obtener la biosíntesis alterada de los ácidos grasos poliinsaturados de cadena larga, y una composicionfarmacéuticacaracterizada porque una formula nutr icional tal como una formula para bebés, un suplemento dietario y un sustituto dietario, un cosmético y unproducto alimenticio para consumo animal que comprende el aceite microbiano o una fraccion del mismo.A Delta 5 desaturase of fatty acid capable of catalyzing the conversion of dihomo-gamma-linolenic acid to arachidonic acid is described, characterized in that it has been encoded by an isolated nucleotide secunecy having a denucleated sequence selected from the group consisting of NO SEQ ID : 1, 13, 17, 19, 21, 22, 23, 24, 25, 26 and 27; and because it comprises an isolated polypeptide that has a polypeptide sequence selected from the group consisting of NO. ECS ID: 2, 3, 4, 5, 6, 7, 14, 16, 18, 20, 28, 29, 30, 31, 32, 33, and 34 or a polypeptide comprising amino acid residues30-38 , 41-44, 171-175, 203-212 and 387-394 of NO. ID. SEC: 2, an oil isolated from host cells expressing fatty acid Delta-5-desaturase; the use of fatty acid Delta-5-desaturase in a method to obtain the altered biosynthesis of long chain polyunsaturated fatty acid, which includes the steps of: Cultivating a microbe that has cells which is containing a transgene that encodes a transgene expression product that desaturates a carbon 5 fatty acid molecule from the carboxyl end of said fatty acid molecule where said transgene is operatively associated with an expression control sequence, under conditions under which said transgene is expressed, whereby the biosynthesis of the long chain polyunsaturated fatty acid in said cells is altered; a microbial oil or a fraction of the same, produced by the use of fatty acid Delta-5-desaturase in the method to obtain the altered biosynthesis of long chain polyunsaturated fatty acids, and a pharmaceutical composition characterized in that a nutritional formula such as a formula for babies, a dietary supplement and a dietary substitute, a cosmetic and a food product for animal consumption comprising microbial oil or a fraction thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/007422 WO1998046765A1 (en) | 1997-04-11 | 1998-04-10 | Methods and compositions for synthesis of long chain polyunsaturated fatty acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020045A1 true AR020045A1 (en) | 2002-04-10 |
Family
ID=45582091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104975A AR020045A1 (en) | 1998-04-10 | 1998-10-06 | A DELTA 5-DESATURASA OF FATTY ACID, ITS USE, AN ISOLATED OIL FROM GUESTS CELLS THAT EXPRESS SUCH DESATURASA, A MICROBIAL OIL OR FRACCIONDEL SAME PRODUCED USING SUCH DESATURASA, AND A NUTRITIONAL FORM A BABY FORMULA , A SUPPLEMENT |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR020045A1 (en) |
-
1998
- 1998-10-06 AR ARP980104975A patent/AR020045A1/en unknown
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