AR019817A1 - MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION - Google Patents
MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITIONInfo
- Publication number
- AR019817A1 AR019817A1 ARP990100666A AR019817A1 AR 019817 A1 AR019817 A1 AR 019817A1 AR P990100666 A ARP990100666 A AR P990100666A AR 019817 A1 AR019817 A1 AR 019817A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- disease
- prepare
- procedure
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos multiadherentes que tienen la formula: (L)pXq, en la cual L es un ligando que puede ser igual o diferente cada vez que ocurre; X es un ligandoque puede ser igual o diferente cada vez que ocurre; p es un numero de 2-10; y q es un numero de1-20; donde cada uno de dichos ligandos comprende un dominiode ligando que es capaz de adherirse a un sustrato de enzima transglicosilasa; o una sal farmacéuticamente aceptable del mismo; con la condicion de que cuandoL es vancomicina, p es 2 y q es1, y el enlace es [C-C], X no es -NH-Q-HN-, donde Q es (CH2)m, -(CH2)2-NH-(CH2)n-NH-(CH2)2-, o -(CH2)n-S-S-(CH2)n-, donde m esun numero de 2-12 y n es un numero de 1-3; también con la condicion de que cuando L es vancomicina, p es 2 y q es 1, y el enlace es [V-V]; X no es alquileno,alquileno interrumpido por oxígeno, o alquileno interrumpido por fenileno a 1,4-dioxifenileno. Uso de dichos compuestos, o una sal farmacéuticamente aceptabledel mismo para preparar un medicamento util para tratar mamíferos que tienen una enfermedad que es aliviada mediante tratamiento con un agente antibacteriano.Procedimiento para la preparacion de dichos compuestos y composicion farmacéutica que los contiene.Multi-stick compounds that have the formula: (L) pXq, in which L is a ligand that can be the same or different each time it occurs; X is a ligand that may be the same or different each time it occurs; p is a number of 2-10; and q is a number of 1-20; wherein each of said ligands comprises a ligand domain that is capable of adhering to a transglycosylase enzyme substrate; or a pharmaceutically acceptable salt thereof; with the proviso that when L is vancomycin, p is 2 and q is 1, and the bond is [CC], X is not -NH-Q-HN-, where Q is (CH2) m, - (CH2) 2-NH- (CH2) n-NH- (CH2) 2-, or - (CH2) nSS- (CH2) n-, where m is a number of 2-12 and n is a number of 1-3; also on the condition that when L is vancomycin, p is 2 and q is 1, and the link is [V-V]; X is not alkylene, alkylene interrupted by oxygen, or alkylene interrupted by phenylene at 1,4-dioxyphenylene. Use of said compounds, or a pharmaceutically acceptable salt thereof to prepare a medicament useful for treating mammals that have a disease that is relieved by treatment with an antibacterial agent. Procedure for the preparation of said compounds and pharmaceutical composition containing them.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7551498P | 1998-02-20 | 1998-02-20 | |
| US7890398P | 1998-03-20 | 1998-03-20 | |
| US8220998P | 1998-04-17 | 1998-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019817A1 true AR019817A1 (en) | 2002-03-20 |
Family
ID=27372700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100666 AR019817A1 (en) | 1998-02-20 | 1999-02-23 | MULTIADHERENT COMPOUNDS, USE OF SUCH COMPOUNDS TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MAMIFERS THAT HAVE A DISEASE THAT IS RELIEFED BY TREATMENT WITH AN ANTIBACTERIAL AGENT, PROCEDURE FOR THE PREPARATION OF THESE COMPOUND COMPOSITIONS AND COMPOSITION |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1060189A1 (en) |
| AR (1) | AR019817A1 (en) |
| AU (1) | AU3307399A (en) |
| CA (1) | CA2318394A1 (en) |
| FR (1) | FR2778184A1 (en) |
| IT (1) | IT1307018B1 (en) |
| WO (1) | WO1999042476A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ301184B6 (en) | 1998-12-23 | 2009-12-02 | Theravance, Inc. | Glycopeptide derivative and pharmaceutical compositions in which they are comprised |
| EP1276759B1 (en) | 2000-05-02 | 2008-07-30 | Theravance, Inc. | Reductive alkylation process on glycopeptides |
| US6656694B2 (en) | 2001-01-11 | 2003-12-02 | Theravance, Inc. | Method for identifying a ligand for a biological substrate |
| WO2003015709A2 (en) * | 2001-08-17 | 2003-02-27 | The Trustees Of Princeton University | Bifunctional glycopeptides antibiotics and combinatorial libraries thereof |
| TWI312785B (en) | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
| TWI275594B (en) | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
| TWI335332B (en) | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| ATE556088T1 (en) | 2002-05-24 | 2012-05-15 | Theravance Inc | CONJUGATE CONTAINING CEPHALOSPORIN AND GLYCOPEPTIDE ANTIBIOTIC |
| DE602004024393D1 (en) | 2003-05-23 | 2010-01-14 | Theravance Inc | CROSS-LINKED GLYCOPEPTIDE-CEPHALOSPORIN ANTIBIOTICS |
| JP4555823B2 (en) | 2003-07-11 | 2010-10-06 | セラヴァンス， インコーポレーテッド | Cross-linked glycopeptide-cephalosporin antibiotics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2441697A (en) * | 1996-04-12 | 1997-11-07 | Eli Lilly And Company | Covalently-linked glycopeptide dimers |
| WO1997038706A1 (en) * | 1996-04-12 | 1997-10-23 | Eli Lilly And Company | Glycopeptide compounds |
| US5977063A (en) * | 1997-05-20 | 1999-11-02 | Eli Lilly And Company | Alkylated hexapeptides |
-
1999
- 1999-02-22 AU AU33073/99A patent/AU3307399A/en not_active Abandoned
- 1999-02-22 IT IT99TO000134 patent/IT1307018B1/en active
- 1999-02-22 CA CA002318394A patent/CA2318394A1/en not_active Abandoned
- 1999-02-22 EP EP99934285A patent/EP1060189A1/en not_active Withdrawn
- 1999-02-22 FR FR9902172A patent/FR2778184A1/en not_active Withdrawn
- 1999-02-22 WO PCT/US1999/003850 patent/WO1999042476A1/en not_active Application Discontinuation
- 1999-02-23 AR ARP990100666 patent/AR019817A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1060189A1 (en) | 2000-12-20 |
| AU3307399A (en) | 1999-09-06 |
| ITTO990134A1 (en) | 2000-08-22 |
| FR2778184A1 (en) | 1999-11-05 |
| WO1999042476A1 (en) | 1999-08-26 |
| CA2318394A1 (en) | 1999-08-26 |
| IT1307018B1 (en) | 2001-10-23 |
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