AR018611A1 - A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS - Google Patents

A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS

Info

Publication number
AR018611A1
AR018611A1 ARP990102331A ARP990102331A AR018611A1 AR 018611 A1 AR018611 A1 AR 018611A1 AR P990102331 A ARP990102331 A AR P990102331A AR P990102331 A ARP990102331 A AR P990102331A AR 018611 A1 AR018611 A1 AR 018611A1
Authority
AR
Argentina
Prior art keywords
administration
procedure
bisphosphonate
treatment
stage
Prior art date
Application number
ARP990102331A
Other languages
Spanish (es)
Original Assignee
Gador Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gador Sa filed Critical Gador Sa
Priority to ARP990102331A priority Critical patent/AR018611A1/en
Priority to CA002308532A priority patent/CA2308532C/en
Priority to US09/570,275 priority patent/US6864228B1/en
Priority to ES00110056T priority patent/ES2238950T3/en
Priority to EP00110056A priority patent/EP1051976B1/en
Priority to KR1020000025525A priority patent/KR20010020838A/en
Priority to AT00110056T priority patent/ATE291921T1/en
Priority to DE60019016T priority patent/DE60019016T2/en
Publication of AR018611A1 publication Critical patent/AR018611A1/en
Priority to US10/931,858 priority patent/US20050026870A1/en
Priority to US12/016,588 priority patent/US7846474B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento aplicable a preparaciones médicas de bisfosfonatos y sus formulaciones, para el tratamiento de la osteogénesis imperfecta. Esteprocedimiento (D2) comprende una primera etapa de administracion de suficiente cantidad de unapreparacion de bisfosfonato durante el tiempo necesariohasta conseguir un grado de densidad mineral volumétrica del tejido cortical de aplicacion, que esté dentro del rango normal (promedio +/- 1Ds). Luegose suspende la administracion de lapreparacion de bisfo sfonato a efectos de posibilitar el desarrollo del momento de inercia seccional. La duracionde la segunda etapa puede determinarse por medio de tomografía computada. Es decir que los períodos de administracion o no del agentemineralizanteestán defin idos o controlados por variables osteologicas precisas y por lo tanto no son fijos. Si durante la segunda etapa la densidad mineral cortical caeen un 5-10% del valor máximo antes obtenido, reanudar la administracion de lapreparacion del bisfosfonato hasta recuperar nuevamente el valormáximo ajustado que corresponda. El procedimiento (D2) propuesto de un período con bisfosfonato, seguido de otro sin el agente bisfosfonato mejorala resistencia a la fractura, siempreque esté la duracion de ambos períodos controlada por variables osteologicas definidas. En la relacion entrearquitectura osea (A) y mineralizacion (B) los resultados de aplicar el presente procedimiento (D2) se aproximan al desarrollo normal (D),por encimade los procedimientos c onocidos (D1) que son más cercanos a los valores sin tratamiento (C). Entre los compuestos activos preferidos están elpamidronato y el olpadronato.A procedure applicable to medical preparations of bisphosphonates and their formulations, for the treatment of osteogenesis imperfecta. This procedure (D2) comprises a first stage of administration of sufficient amount of a bisphosphonate preparation for the necessary time until a degree of volumetric mineral density of the cortical application tissue is achieved, which is within the normal range (average +/- 1Ds). Then suspends the administration of the preparation of bisfo sfonato in order to enable the development of the moment of sectional inertia. The duration of the second stage can be determined by computed tomography. In other words, the periods of administration or not of the mineralizing agent are defined or controlled by precise osteological variables and therefore are not fixed. If during the second stage the cortical mineral density drops 5-10% of the maximum value previously obtained, resume the administration of bisphosphonate preparation until the corresponding maximum adjusted value is recovered again. The proposed procedure (D2) of a period with bisphosphonate, followed by another without the bisphosphonate agent improves fracture resistance, provided that the duration of both periods is controlled by defined osteological variables. In the relationship between bone architecture (A) and mineralization (B) the results of applying this procedure (D2) approximate normal development (D), above the known procedures (D1) that are closer to the values without treatment (C). Among the preferred active compounds are pamidronate and olpadronate.

ARP990102331A 1999-05-11 1999-05-12 A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS AR018611A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ARP990102331A AR018611A1 (en) 1999-05-12 1999-05-12 A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS
CA002308532A CA2308532C (en) 1999-05-12 2000-05-11 Use of bisphosphonates for the treatment of osteogenesis imperfecta
US09/570,275 US6864228B1 (en) 1999-05-12 2000-05-12 Use of bisphosphonates for the treatment of osteogenesis imperfecta
ES00110056T ES2238950T3 (en) 1999-05-12 2000-05-12 USE OF BISPHOSPHONATES FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS.
EP00110056A EP1051976B1 (en) 1999-05-12 2000-05-12 Use of bisphosphate for the treatment of osteogenesis imperfecta
KR1020000025525A KR20010020838A (en) 1999-05-12 2000-05-12 Use of bisphosphonates for the treatment of osteogenesis imperfecta
AT00110056T ATE291921T1 (en) 1999-05-12 2000-05-12 USE OF BISPHOSPHONATES TO TREAT OSTEOGENESIS IMPERFECTA
DE60019016T DE60019016T2 (en) 1999-05-12 2000-05-12 Use of bisphosphonates for the treatment of osteogenesis Imperfecta
US10/931,858 US20050026870A1 (en) 1999-05-12 2004-09-01 Use of bisphosphonates for the treatment of osteogenesis imperfecta
US12/016,588 US7846474B2 (en) 1999-05-11 2008-01-18 Use of bisphosphonates for the treatment of osteogenesis imperfecta

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP990102331A AR018611A1 (en) 1999-05-12 1999-05-12 A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS

Publications (1)

Publication Number Publication Date
AR018611A1 true AR018611A1 (en) 2001-11-28

Family

ID=36202200

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102331A AR018611A1 (en) 1999-05-11 1999-05-12 A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS

Country Status (3)

Country Link
KR (1) KR20010020838A (en)
AR (1) AR018611A1 (en)
DE (1) DE60019016T2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180115979A (en) 2017-04-14 2018-10-24 연세대학교 산학협력단 Composition for treating and preventing of chronic allograft dysfuction comprising bisphosphonate

Also Published As

Publication number Publication date
DE60019016D1 (en) 2005-05-04
DE60019016T2 (en) 2006-05-04
KR20010020838A (en) 2001-03-15

Similar Documents

Publication Publication Date Title
Shabahang et al. A comparative study of root-end induction using osteogenic protein-1, calcium hydroxide, and mineral trioxide aggregate in dogs
US4297993A (en) Aid for osteosynthesis
Pradhan et al. Comparative evaluation of endodontic management of teeth with unformed apices with mineral trioxide aggregate and calcium hydroxide
ES2904826T3 (en) Biomimetic mineral-based endodontic cement composition
ES2235026T3 (en) COMPOSITION OF OSEO IMPLANT BASED ON CALCIUM PHOSPHATE / SULPHATE.
ES2199185T3 (en) MATERIAL FOR REABSORBABLE OSEO IMPLANT AND AS A PROCEDURE FOR THE PRODUCTION OF THE SAME.
Madan et al. Tooth remineralization using bio-active glass-A novel approach
SE9102778D0 (en) IMPLANT MEDICAL DEVICE
Thibodeau Case report: pulp revascularization of a necrotic, infected, immature, permanent tooth
ES2117724T3 (en) COVERING DEVICE FOR OSEA CAVITY.
ES2023947B3 (en) APPLICATOR MEMBER FOR PERMANENT ANCHORS IN BONE TISSUES
DE69633537D1 (en) Oral composition with improved absorption and retention of antibacterial compounds on the tooth surface tissues
Madfa et al. Endodontic repair filling materials: a review article.
D’Arcangelo et al. Use of MTA for orthograde obturation of nonvital teeth with open apices: report of two cases
EP4049630B1 (en) Container for bone material storage, mixing and delivery
JPS5629511A (en) Dental surgical fang filling paste
IT1196100B (en) SEMI-PLANT OF BIOINERTE MATERIAL
AR018611A1 (en) A PROCEDURE APPLICABLE TO MEDICAL PREPARATIONS OF BISPHOSPHONATES AND ITS FORMULATIONS, FOR THE TREATMENT OF IMPERFECT OSTEOGENESIS
CA2308532A1 (en) Use of bisphosphonates for the treatment of osteogenesis imperfecta
Slutzkey et al. Temperature changes of one-piece implants during the setting of acrylic resin temporary crown. The effect of implant diameter. An in vitro study
Karthikeson et al. Pulp capping agents-a review
WO2014181299A1 (en) A product for use in the therapeutic treatment of periodontitis and peri- implantitis
RU2112550C1 (en) Chonsuride as a preparation to fill postoperative osseous cavities
Neville et al. The laterally positioned odontogenic keratocyst: a case report
Galler et al. Bioceramic materials in regenerative endodontics

Legal Events

Date Code Title Description
FB Suspension of granting procedure