AR018408A1 - PIRROL SUBSTITUTE COMPOUND 2-INDOLINONE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, USE OF SUCH COMPOSITE IN A 'IN VIVO' METHOD AND ITS USE FOR THE PREPARATION OF SUCH COMPOSITION - Google Patents

PIRROL SUBSTITUTE COMPOUND 2-INDOLINONE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, USE OF SUCH COMPOSITE IN A 'IN VIVO' METHOD AND ITS USE FOR THE PREPARATION OF SUCH COMPOSITION

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Publication number
AR018408A1
AR018408A1 ARP990102526A ARP990102526A AR018408A1 AR 018408 A1 AR018408 A1 AR 018408A1 AR P990102526 A ARP990102526 A AR P990102526A AR P990102526 A ARP990102526 A AR P990102526A AR 018408 A1 AR018408 A1 AR 018408A1
Authority
AR
Argentina
Prior art keywords
group
carboxyl
alkyl
amido
cycloalkyl
Prior art date
Application number
ARP990102526A
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Spanish (es)
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Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of AR018408A1 publication Critical patent/AR018408A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto pirrol sustituido 2-indolinona, que tiene la estructura química de la formula (I) en la cual R1 se selecciona del grupo que consiste enhidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, arilo, oxhidrilo, alcoxilo, C-carboxilo, O-carboxilo, acetilo, C-amido, C-tioamido, sulfonilo ytrihalometanosulfonilo, R2 se selecciona del grupo que consiste en hidrogeno, halogeno, alquilo, cicloalquilo, arilo, heteroarilo y heteroalicíclico. R3, R4,R5y R6 se seleccionan independientemente delgrupo que consiste en hidrogeno, alquilo, trihaloalquilo, cicloalquilo, alquenilo, alquinilo, arilo, heteroarilo,heteroalicíclico, oxhidrilo, alcoxilo, ariloxilo, mercapto, alquiltio, ariltio, sulfinilo, sulfonilo, S-sulfonamido, N-sulfonamido, triohalometanosulfonamido,carbonilo, C-carboxilo, O-carboxilo, C-amido, N-amido, ciano, nitro, halo, O-carbamilo, N-carbamilo, O-tiocarbamilo, N-tiocarbamilo, amino NR11R12, R11 y R12se seleccionan independientemente del grupo que consiste en hidrogeno,alquilo, cicloalquilo, arilo, carbonilo, acetilo, sulfonilo, trifluorometanosulfonilo, ycuando está combinado, es un anillo heteroalicíclico de cinco o seis miembros, R3 y R4, R4 y R5 o R4 y R5 se pueden combinar para formar un anillo de seismiembros, un grupo metilendioxi o un grupo etilendioxi, R7 se selecciona del grupo que consiste en hidrogeno, alquilo, cicloalquilo, alquenilo, alquinilo,arilo, heteroarilo, heteroalicíclico, oxhidrilo, alcoxilo, ariloxilo, carbonilo, acetilo,C-amido,C-tioamido, amidino, C-carboxilo,O-carboxilo, sulfonilo ytrihalometanosulfonilo; R8,R9 y R10se seleccionan independientemente del grupo formado de H, alquilo, trihaloalquilo, cicloalquilo, alquenilo, alquinilo,arilo,heteroarilo,heterolalicíclico, oxhidrilo,alcoxilo, ariloxilo, mercapto, alquiltio, ariltio, sulfinilo, sulfonilo, S-sulfonamido, N-sulfonamido, carbonilo, C-carboxilo, O-carboxilo,ciano, nitro, halo, O-carbamilo, N-carbamilo, O-tiocarbamilo, N-tiocarbamilo, C-amido, N-amido, amino y NR11R12, con la condicion de quepor lo menos uno de R8,R9 y R10 sea un grupo que tiene la formula: (alqu1)Z en la cual Alqu1 se selecciona del grupo formado de alquilo, alquenilo, o alquiniloA substituted 2-indolinone pyrrole compound, which has the chemical structure of formula (I) in which R 1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, oxhydryl, alkoxy, C-carboxyl, O -carboxyl, acetyl, C-amido, C-thioamido, sulfonyl and ytrihalomethanesulfonyl, R2 is selected from the group consisting of hydrogen, halogen, alkyl, cycloalkyl, aryl, heteroaryl and heteroalicyclic. R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, oxhydryl, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamide , N-sulfonamido, triohalomethanesulfonamido, carbonyl, C-carboxyl, O-carboxyl, C-amido, N-amido, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, amino NR11R12, R11 and R12 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl, acetyl, sulfonyl, trifluoromethanesulfonyl, and when combined, it is a five or six membered heteroalicyclic ring, R3 and R4, R4 and R5 or R4 and R5 can be combined to form a seismic ring, a methylenedioxy group or an ethylenedioxy group, R7 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, oxhydryl, al coxyl, aryloxy, carbonyl, acetyl, C-amido, C-thioamido, amidino, C-carboxyl, O-carboxyl, sulfonyl and ytrihalomethanesulfonyl; R8, R9 and R10 are independently selected from the group consisting of H, alkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterolalicyclic, oxhydryl, alkoxy, aryloxy, mercapto, alkylthio, arylthio, sulfinyl, sulfonyl, S-sulfonamido, N -sulfonamido, carbonyl, C-carboxyl, O-carboxyl, cyano, nitro, halo, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, amino and NR11R12, with the condition where at least one of R8, R9 and R10 is a group having the formula: (alky1) Z in which Alk1 is selected from the group consisting of alkyl, alkenyl, or alkynyl

ARP990102526A 1998-05-29 1999-05-28 PIRROL SUBSTITUTE COMPOUND 2-INDOLINONE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, USE OF SUCH COMPOSITE IN A 'IN VIVO' METHOD AND ITS USE FOR THE PREPARATION OF SUCH COMPOSITION AR018408A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8731098P 1998-05-29 1998-05-29
US11610699P 1999-01-15 1999-01-15

Publications (1)

Publication Number Publication Date
AR018408A1 true AR018408A1 (en) 2001-11-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102526A AR018408A1 (en) 1998-05-29 1999-05-28 PIRROL SUBSTITUTE COMPOUND 2-INDOLINONE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, USE OF SUCH COMPOSITE IN A 'IN VIVO' METHOD AND ITS USE FOR THE PREPARATION OF SUCH COMPOSITION

Country Status (24)

Country Link
US (2) US6395734B1 (en)
EP (2) EP2020408B1 (en)
JP (1) JP4528440B2 (en)
KR (1) KR100743287B1 (en)
CN (1) CN1250526C (en)
AR (1) AR018408A1 (en)
AU (1) AU759226B2 (en)
BR (1) BR9910792A (en)
CA (1) CA2314156C (en)
CO (1) CO5031249A1 (en)
DK (1) DK2020408T3 (en)
EA (1) EA005032B1 (en)
ES (1) ES2429573T3 (en)
HK (1) HK1126770A1 (en)
HU (1) HUP0103617A2 (en)
IL (2) IL139934A0 (en)
NO (1) NO318083B1 (en)
NZ (1) NZ508815A (en)
PL (1) PL344477A1 (en)
PT (1) PT2020408E (en)
SK (1) SK287132B6 (en)
TR (1) TR200003514T2 (en)
TW (1) TWI229073B (en)
WO (1) WO1999061422A1 (en)

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