AR017480A1 - PROLONGED RELEASE MICROSPHERES TO ENCAPSULATE ANALOGS OF THE LUTEINIZING HORMONE RELEASING HORMONE AND METHOD TO PREPARE THEM - Google Patents

PROLONGED RELEASE MICROSPHERES TO ENCAPSULATE ANALOGS OF THE LUTEINIZING HORMONE RELEASING HORMONE AND METHOD TO PREPARE THEM

Info

Publication number
AR017480A1
AR017480A1 ARP990101361A ARP990101361A AR017480A1 AR 017480 A1 AR017480 A1 AR 017480A1 AR P990101361 A ARP990101361 A AR P990101361A AR P990101361 A ARP990101361 A AR P990101361A AR 017480 A1 AR017480 A1 AR 017480A1
Authority
AR
Argentina
Prior art keywords
release
microsphere
hormone
luteinizing hormone
emulsion phase
Prior art date
Application number
ARP990101361A
Other languages
Spanish (es)
Original Assignee
Dong Kook Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharm Co Ltd filed Critical Dong Kook Pharm Co Ltd
Publication of AR017480A1 publication Critical patent/AR017480A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Abstract

Se describe una microesfera de liberacion prolongada que puede liberar en forma constante drogas medicinales tales como análogos de la hormonaliberadora de la hormona luteinizante y las encapsula con altas tasas de contenido. Se prepara disolviendo un copolímero de láctido y glicolido en clorurode metileno, disolviendo un análogo de la hormona liberadora de la hormona luteinizante y un material controlador de la liberacion en un solventeauxiliar, combinando las dos soluciones obtenidas entre sípara producir una fase de emulsion, dispersando la fase de emulsion en una solucion de alcoholpolivinílico en agua destilada para dar un sistema de emulsion unica, eliminando el solvente combinado de la fase de emulsion para generar unamicroesfera polimérica; secando por congelacion la microesfera polimérica. La microesfera preparada tiene una estructura interna mucho más fina, en virtud delo cual la microesfera asegura un índice de liberacion constante. El sistema de emulsion unica que simplifica la preparacion, da lugar al mantenimiento de uncontenido de fármaco de 10% o más. Los grupos cargados de los materiales controladores de la liberacion asociados con los polímeros minimizan el excesode liberacion de las drogas con cargas opuestas en una etapa inicial, por lo que cumplen una funcion importante en el mantenimiento de la velocidad deliberacion constante.A prolonged-release microsphere is described that can constantly release medicinal drugs such as luteinizing hormone hormone-releasing analogues and encapsulates them with high content rates. It is prepared by dissolving a copolymer of lactide and glycolide in methylene chloride, dissolving an analogue of the luteinizing hormone releasing hormone and a release controlling material in an auxiliary solvent, combining the two solutions obtained from each other to produce an emulsion phase, dispersing the emulsion phase in a solution of polyvinyl alcohol in distilled water to give a unique emulsion system, removing the combined solvent from the emulsion phase to generate a polymeric microsphere; freezing the polymer microsphere. The prepared microsphere has a much finer internal structure, under which the microsphere ensures a constant release rate. The unique emulsion system that simplifies the preparation, results in the maintenance of a drug content of 10% or more. The groups loaded with the release control materials associated with the polymers minimize the excess release of drugs with opposite charges at an initial stage, thus fulfilling an important function in maintaining constant deliberation speed.

ARP990101361A 1998-12-30 1999-03-26 PROLONGED RELEASE MICROSPHERES TO ENCAPSULATE ANALOGS OF THE LUTEINIZING HORMONE RELEASING HORMONE AND METHOD TO PREPARE THEM AR017480A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019980062142A KR100321854B1 (en) 1998-12-30 1998-12-30 Long-term sustained-release microspheres containing luteinizing hormone releasing hormone homologues and a method of producing the same

Publications (1)

Publication Number Publication Date
AR017480A1 true AR017480A1 (en) 2001-09-05

Family

ID=19568831

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101361A AR017480A1 (en) 1998-12-30 1999-03-26 PROLONGED RELEASE MICROSPHERES TO ENCAPSULATE ANALOGS OF THE LUTEINIZING HORMONE RELEASING HORMONE AND METHOD TO PREPARE THEM

Country Status (10)

Country Link
JP (1) JP2002534392A (en)
KR (1) KR100321854B1 (en)
CN (1) CN1348383A (en)
AR (1) AR017480A1 (en)
BR (1) BR9916945A (en)
CA (1) CA2358495A1 (en)
MX (1) MXPA01005540A (en)
TR (1) TR200101913T2 (en)
WO (1) WO2000040259A1 (en)
ZA (1) ZA992059B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
WO2003075958A1 (en) 2002-03-11 2003-09-18 Takeda Chemical Industries, Ltd. Remedies for sex hormone-dependent disease
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
DK1532985T3 (en) 2002-06-25 2016-12-05 Takeda Pharmaceuticals Co PROCEDURE FOR PREPARING A COMPOSITION WITH LONG-TERM RELEASE
CA2533314C (en) * 2003-07-18 2013-07-09 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
BR0305373A (en) * 2003-11-06 2005-06-28 Iseu Da Silva Nunes Nelson Edu Ammonium and magnesium phospholinoleate palmitoleate anhydride protein aggregate immunomodulator and process for obtaining and formulating it
TW200529890A (en) 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
KR100622996B1 (en) * 2005-03-03 2006-09-14 한국과학기술원 Nonporous microspheres including drug and manufacturing method thereof
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
WO2009150136A1 (en) * 2008-06-09 2009-12-17 Boehringer Ingelheim International Gmbh Novel embedment particles for inhalation
CN104873979A (en) 2008-08-29 2015-09-02 健赞股份有限公司 Controlled-released Peptide Formulations
KR101663560B1 (en) * 2009-02-13 2016-10-10 동국제약 주식회사 Method for manufacturing uniform delayed-release microspheres
DE102011114864A1 (en) 2011-10-05 2013-04-11 Acino Ag Process for producing a homogeneous powder mixture and method for producing an implant and implant
HUE045661T2 (en) 2011-12-14 2020-01-28 Abraxis Bioscience Llc Use of polymeric excipients for lyophilization or freezing of particles
BR112016002342A8 (en) * 2013-08-06 2018-01-23 Dong Kook Pharm Co Ltd entecavir microsphere, method for preparation of an entecavir microsphere, and pharmaceutical composition
CN109394705B (en) * 2018-12-04 2021-11-19 沈阳药科大学 Goserelin sustained-release microsphere freeze-dried powder and preparation method thereof
US11617720B2 (en) 2020-05-08 2023-04-04 M. Technique Co., Ltd. Main agent uniformly dispersed microsphere and a sustained release formulation comprising the same
KR20220163418A (en) * 2020-05-08 2022-12-09 엠. 테크닉 가부시키가이샤 Microspheres in which physiologically active substances are uniformly dispersed and sustained-release preparations containing the microspheres
KR20220163416A (en) 2020-05-08 2022-12-09 엠. 테크닉 가부시키가이샤 Microspheres in which physiologically active substances are uniformly dispersed and sustained-release preparations containing the microspheres

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
CH661206A5 (en) * 1983-09-23 1987-07-15 Debiopharm Sa PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HORMONDEPENDENT DISEASES.
CH660302A5 (en) * 1984-10-17 1987-04-15 Debiopharm Sa HETEROGENEOUS PHASE MICRO-ENCAPSULATION PROCESS OF WATER-SOLUBLE DRUG SUBSTANCES.
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
YU48420B (en) * 1991-03-25 1998-07-10 Hoechst Aktiengesellschaft PROCEDURE FOR OBTAINING BIOLOGICAL DEGRADABLE MICROPARTICLES WITH LONG TERM ACTION
FR2693905B1 (en) * 1992-07-27 1994-09-02 Rhone Merieux Process for the preparation of microspheres for the sustained release of the hormone LHRH and its analogs, microspheres and formulations obtained.

Also Published As

Publication number Publication date
JP2002534392A (en) 2002-10-15
KR100321854B1 (en) 2002-08-28
TR200101913T2 (en) 2001-11-21
CN1348383A (en) 2002-05-08
CA2358495A1 (en) 2000-07-13
BR9916945A (en) 2001-11-06
MXPA01005540A (en) 2004-06-22
ZA992059B (en) 1999-09-27
WO2000040259A1 (en) 2000-07-13
KR20000045577A (en) 2000-07-25

Similar Documents

Publication Publication Date Title
AR017480A1 (en) PROLONGED RELEASE MICROSPHERES TO ENCAPSULATE ANALOGS OF THE LUTEINIZING HORMONE RELEASING HORMONE AND METHOD TO PREPARE THEM
Ravi et al. Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system
DK169119B1 (en) Process for the preparation of a pharmaceutical composition in microcapsule form and thus prepared composition
JP3761591B2 (en) Method for producing microspheres that gradually release LHRH hormone and analogs thereof, and microspheres and formulations containing the same
ES2764971T3 (en) Emulsion-based process for preparing microparticles and working head assembly for use with it
ES2029880T3 (en) PHARMACEUTICAL PRODUCTS RELEASE DEVICE.
RU97115570A (en) APPLICATION OF INORGANIC AEROGELS IN PHARMACY
AU7479796A (en) Preparation of peptide containing biodegradable microspheres by melt process
EP0467389A2 (en) Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer
AR019114A1 (en) NEW MICRO-SPHERES BASED ON POLI (METHYLID MALONATE), ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR19990071595A (en) The present invention relates to a method for producing a morphologically uniform microcapsule and a microcapsule
DE69414046D1 (en) Morphine-containing medicinal compositions with delayed drug delivery
CU22838A3 (en) COMPOSITIONS TO CONTROL BACTERIAL COLONIZATION
CN1407888A (en) Film preparation for biphasic release of pharmacologically active or other substances
Tsai et al. Paclitaxel-loaded polymeric microparticles: quantitative relationships between in vitro drug release rate and in vivo pharmacodynamics
EP1532985B1 (en) Process for producing a sustained-release composition
US9931411B2 (en) Microparticles containing physiologically active peptide, method for preparing the same, and pharmaceutical composition comprising the same
CA2452056A1 (en) Compositions of bioactive material particles dispersed in a continuous solid encapsulating material
CN102159192B (en) Preparation method of biodegradable micro-particles containing drugs
Luan et al. Modification of the tri-phasic drug release pattern of leuprolide acetate-loaded poly (lactide-co-glycolide) microparticles
RU2005101640A (en) SHORT-TERM DEPOT COMPOSITIONS
DE60004334D1 (en) VACCINE COMPOSITION BASED ON PARTICLES
Reza Self-emulsifying drug delivery systems: a review
CN102552187A (en) Oral hydroxyl silk peptide nanoparticles and preparation method thereof
RU2219927C1 (en) Ancardin-retard as agent with prolonged anti-calcium effect