AR016700A1 - OMEPRAZOL SHAPES CRYSTALINE. PROCESS FOR PREPARATION, PHARMACEUTICAL FORMULATIONS CONTAINING IT, AND USE OF THE SAME - Google Patents

OMEPRAZOL SHAPES CRYSTALINE. PROCESS FOR PREPARATION, PHARMACEUTICAL FORMULATIONS CONTAINING IT, AND USE OF THE SAME

Info

Publication number
AR016700A1
AR016700A1 ARP980105984A ARP980105984A AR016700A1 AR 016700 A1 AR016700 A1 AR 016700A1 AR P980105984 A ARP980105984 A AR P980105984A AR P980105984 A ARP980105984 A AR P980105984A AR 016700 A1 AR016700 A1 AR 016700A1
Authority
AR
Argentina
Prior art keywords
methoxy
preparation
sulfinyl
benzimidazole
pyridinyl
Prior art date
Application number
ARP980105984A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE1998/002028 external-priority patent/WO1999008500A2/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR016700A1 publication Critical patent/AR016700A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a una forma cristalina nueva de 5-metoxi-2-[[(4-metoxi-3,5-dimetil-2-piridinil)metil]sulfinil]-1H-bencimidazol, que se conoce con elnombre genérico de omeprazol. Además,la presente también se refiere al uso de la formacristali na nueva de 5-metoxi-2-[[(4-metoxi-3,5-dimetil-2-piridinil)metil]sulfinil]-1H-bencimidazol para el tratamiento de trastornos gastrointestinales, composiciones farmacéuticas que lo contienen, como así también procesos para lapreparacion dela forma cr istalina nueva de 5-metoxi-2-[[(4-metoxi-3,5-dimetil-2-piridinil)metil]sulfinil]-1H-bencimidazol. El omeprazol forma A proporciona unpatron de difraccion de polvo por rayos X que exhiben sustancialmente los siguientes d-valores (TablaI), es termodin ámicamente estable y esencialmente nohigroscopico.This refers to a novel crystalline form of 5-methoxy-2 - [[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole, which is known by the generic name of omeprazole . In addition, this also refers to the use of the new 5-methoxy-2 - [[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole formalin for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it, as well as processes for the preparation of the new cr istaline form of 5-methoxy-2 - [[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfinyl] -1H -benzimidazole. Omeprazole form A provides an X-ray powder diffraction unpatron that exhibits substantially the following d-values (Table I), is thermodynamically stable and essentially nonhigroscopic.

ARP980105984A 1998-11-10 1998-11-25 OMEPRAZOL SHAPES CRYSTALINE. PROCESS FOR PREPARATION, PHARMACEUTICAL FORMULATIONS CONTAINING IT, AND USE OF THE SAME AR016700A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SE1998/002028 WO1999008500A2 (en) 1998-11-10 1998-11-10 New crystalline form of omeprazole

Publications (1)

Publication Number Publication Date
AR016700A1 true AR016700A1 (en) 2001-07-25

Family

ID=43735642

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105984A AR016700A1 (en) 1998-11-10 1998-11-25 OMEPRAZOL SHAPES CRYSTALINE. PROCESS FOR PREPARATION, PHARMACEUTICAL FORMULATIONS CONTAINING IT, AND USE OF THE SAME

Country Status (5)

Country Link
KR (1) KR100572297B1 (en)
AR (1) AR016700A1 (en)
MY (1) MY118724A (en)
SA (1) SA99190998B1 (en)
TN (1) TNSN98221A1 (en)

Also Published As

Publication number Publication date
KR20010107953A (en) 2001-12-07
TNSN98221A1 (en) 2005-03-15
MY118724A (en) 2005-01-31
KR100572297B1 (en) 2006-04-24
SA99190998B1 (en) 2006-03-25

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Legal Events

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