AR015307A1 -
CRYSTAL FORMS OF PIRAZINE MONOCLORHYDRATE, COMPOSITIONS, TREATMENT METHOD THAT USES THEM AND METHOD OF PREPARATION OF SUCH FORMS.
- Google Patents
CRYSTAL FORMS OF PIRAZINE MONOCLORHYDRATE, COMPOSITIONS, TREATMENT METHOD THAT USES THEM AND METHOD OF PREPARATION OF SUCH FORMS.
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Publication of AR015307A1publicationCriticalpatent/AR015307A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Dos formas polimorficas cristalinas de monoclorhidrato de (7S-9aS)-7-[3-cianofenoxi]metil-2-(5-fluoropirimidin-2-il)2,3,4,6,7,8,9,9a-octahidro-1-H pirido[1,2-a]pirazina son la forma A y la forma B. La composicion farmacéutica que contiene al menos uno de estos polimorfos presenta una estabilidad ventajosa paraformulaciones para tratar la ansiedad, depresion y trastornos psicoticos como son la psicosis afectiva, esquizofrenia y trastornos esquizo-afectivos. Laadministracion de esta composicion farmacéutica es oral mediante comprimidos o cápsulas preferiblemente. También se describe un procedimiento de preparacion delas formas A y B así como métodos de tratamiento que lo utilizan.Two crystalline polymorphic forms of (7S-9aS) -7- [3-cyanophenoxy] methyl-2- (5-fluoropyrimidin-2-yl) 2,3,4,6,7,8,9,9a-octahydrohydrochloride monohydrochloride -1-H pyrido [1,2-a] pyrazine are form A and form B. The pharmaceutical composition containing at least one of these polymorphs has an advantageous stability for formulations to treat anxiety, depression and psychotic disorders such as affective psychosis, schizophrenia and schizo-affective disorders. The administration of this pharmaceutical composition is oral by tablets or capsules preferably. It also describes a procedure for preparing forms A and B as well as treatment methods that use it.
ARP9901024091999-05-221999-05-20
CRYSTAL FORMS OF PIRAZINE MONOCLORHYDRATE, COMPOSITIONS, TREATMENT METHOD THAT USES THEM AND METHOD OF PREPARATION OF SUCH FORMS.
AR015307A1
(en)
OLANZAPINE POLYMORPH DIHYDRATE, PHARMACEUTICAL FORMULATIONS CONTAINING THEM AS AN ACTIVE INGREDIENT AND METHOD FOR TREATING PSYCHOTIC PATHOLOGIES, SUCH AS SCHIZOPHRENIA, ANXIETY, FUNCTIONAL INTESTINAL DISORDERS AND PSYCHOSIS APPLYING SUCH FORMULATIONS
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Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders, process for their preparation, pharmaceutical compositions containing them and their use
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COMPOUNDS DERIVED FROM OCTAHIDRO-PIRROLO [1,2-A] -PYRAZINE 2,7-SUBSTITUTES, PHARMACEUTICAL COMPOSITIONS AND USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.
COMPOUNDS DERIVED FROM 1- (2-METOXIFENIL) -4- (FENOXIALQUILEN) -PIPERAZINE; PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM; A PROCESS FOR THE PREPARATION OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AND USE OF SUCH COMPOUNDS