AR014847A1 - 4-AMINO- (ETILAMINO) -OOPINDIN OXINDOLS OF THE DOPAMINE SELF-RECEPTOR AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS - Google Patents

4-AMINO- (ETILAMINO) -OOPINDIN OXINDOLS OF THE DOPAMINE SELF-RECEPTOR AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS

Info

Publication number
AR014847A1
AR014847A1 ARP990101678A ARP990101678A AR014847A1 AR 014847 A1 AR014847 A1 AR 014847A1 AR P990101678 A ARP990101678 A AR P990101678A AR P990101678 A ARP990101678 A AR P990101678A AR 014847 A1 AR014847 A1 AR 014847A1
Authority
AR
Argentina
Prior art keywords
amino
pharmaceutical composition
oxindols
oopindin
etilamino
Prior art date
Application number
ARP990101678A
Other languages
Spanish (es)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR014847A1 publication Critical patent/AR014847A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-Amino-(etilamino)-oxindoles agonistas del autoreceptor de dopamina, que comprende un compuesto de formula (I), donde R1 y R2 son cada uno,independientemente, hidrogeno, alquilo C1-10, o (CH2)mR4, donde R4 es fenilo o naftilo que puede sustituirse por uno o dos sustituyentes seleccionados delgrupo formado por alquilo C1-6, halogeno, alcoxido C1-6 y trifluormetilo y m es de 1 a 5; y R3 es hidrogeno o alquilo C1-6; o sales farmacéuticamente aceptablede los mismos y una composicion farmacéuticaque los comprende.4-Amino- (ethylamino) -oxyindole agonists of the dopamine autoreceptor, comprising a compound of formula (I), where R1 and R2 are each, independently, hydrogen, C1-10 alkyl, or (CH2) mR4, where R4 it is phenyl or naphthyl which can be substituted by one or two substituents selected from the group consisting of C1-6 alkyl, halogen, C1-6 alkoxy and trifluoromethyl and m is from 1 to 5; and R3 is hydrogen or C1-6 alkyl; or pharmaceutically acceptable salts thereof and a pharmaceutical composition comprising them.

ARP990101678A 1998-04-13 1999-04-12 4-AMINO- (ETILAMINO) -OOPINDIN OXINDOLS OF THE DOPAMINE SELF-RECEPTOR AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS AR014847A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5883498A 1998-04-13 1998-04-13

Publications (1)

Publication Number Publication Date
AR014847A1 true AR014847A1 (en) 2001-03-28

Family

ID=22019205

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101678A AR014847A1 (en) 1998-04-13 1999-04-12 4-AMINO- (ETILAMINO) -OOPINDIN OXINDOLS OF THE DOPAMINE SELF-RECEPTOR AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS

Country Status (8)

Country Link
EP (1) EP1073636A1 (en)
JP (1) JP2002511450A (en)
CN (1) CN1297439A (en)
AR (1) AR014847A1 (en)
AU (1) AU3555099A (en)
CA (1) CA2327477A1 (en)
WO (1) WO1999052870A1 (en)
ZA (1) ZA992670B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR032641A1 (en) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd RECEIVER SUBTIPE AGONIST 5-HT 1A.
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR033485A1 (en) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd MEDICINAL SUBSTANCE OF ARIPIPRAZOL OF LOW HYGROSCOPICITY AND PROCESS FOR THE PREPARATION OF THE SAME
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
GB8712073D0 (en) * 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
WO1993023035A2 (en) * 1992-05-18 1993-11-25 Smithkline Beecham Plc Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease
EP0923551B1 (en) * 1996-08-27 2002-06-05 American Home Products Corporation 4-aminoethoxy indolone derivatives

Also Published As

Publication number Publication date
CA2327477A1 (en) 1999-10-21
CN1297439A (en) 2001-05-30
JP2002511450A (en) 2002-04-16
WO1999052870A1 (en) 1999-10-21
ZA992670B (en) 2000-10-12
AU3555099A (en) 1999-11-01
EP1073636A1 (en) 2001-02-07

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