AR013347A1 - USE OF LOW MOLECULAR WEIGHT HEPARINES FOR THE PREPARATION OF MEDICINES FOR THE PREVENTION AND TREATMENT OF BRAIN EDEMAS - Google Patents
USE OF LOW MOLECULAR WEIGHT HEPARINES FOR THE PREPARATION OF MEDICINES FOR THE PREVENTION AND TREATMENT OF BRAIN EDEMASInfo
- Publication number
- AR013347A1 AR013347A1 ARP980102471A AR013347A1 AR 013347 A1 AR013347 A1 AR 013347A1 AR P980102471 A ARP980102471 A AR P980102471A AR 013347 A1 AR013347 A1 AR 013347A1
- Authority
- AR
- Argentina
- Prior art keywords
- molecular weight
- low molecular
- prevention
- treatment
- heparin
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Utilizacion de las heparinas de bajo peso molecular para el tratamiento y prevencion de edemas cerebrales mediante la preparacion de medicamentos queutilizan dichos polisacáridos sulfatados, preferentemente heparinas de bajo peso molecular, talcomo entre 1000 y 10000 daltons, particularmente entre 4000y 5000 daltons. Dichas heparinas contienen un ácido 2-0-sulfo-4- enopiranosuronico en una de sus actividades. La heparina patron es unpolisacárido sulfatado de peso molecularmedio de 12000-15000 daltons, aislado de las mucosas intestinales de la vaca, del cordero y del cerdo. La heparina esutilizada en clínica para la prevencion y el tratamiento de los desordenes tromboembolicos pero a veces provoca hemorragias. Desde hace una década, laheparina se ha reemplazado, progresivamente, por las heparinas de bajo peso molecular, que no presentan ya el inconveiniente de hacer sangrar, ounicamente lo hacen en un grado menor, y que ya no noecsitan más que una inyeccion por día, en lugar de 2 a 3 inyecciones por día en el caso de la heparinapatron. Estas heparinas de bajo peso molecular se preparan, principalmente, por fraccionamiento , despolimerizacion controlada de la heprina y por síntesisquímica.Use of low molecular weight heparins for the treatment and prevention of cerebral edema by preparing drugs that use said sulfated polysaccharides, preferably low molecular weight heparins, such as between 1,000 and 10,000 Daltons, particularly between 4,000 and 5,000 Daltons. These heparins contain a 2-0-sulfo-4-enopyranosuronic acid in one of their activities. Standard heparin is a 12,000-15,000 dalton average molecular weight sulphated polysaccharide isolated from the intestinal mucosa of cattle, lambs and pigs. Heparin is used clinically for the prevention and treatment of thromboembolic disorders but sometimes causes bleeding. For a decade, heparin has been progressively replaced by low-molecular-weight heparins, which no longer have the inconvenience of bleeding, or only do so to a lesser degree, and which no longer require more than one injection per day, instead of 2 to 3 injections per day in the case of heparinapatron. These low molecular weight heparins are mainly prepared by fractionation, controlled depolymerization of heprin and by chemical synthesis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70655197A | 1997-05-28 | 1997-05-28 | |
| FR9706551A FR2763849B1 (en) | 1997-05-28 | 1997-05-28 | USE OF LOW MOLECULAR WEIGHT HEPARINS FOR THE PREVENTION AND TREATMENT OF CEREBRAL EDEMAS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013347A1 true AR013347A1 (en) | 2000-12-27 |
Family
ID=45725213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102471 AR013347A1 (en) | 1997-05-28 | 1998-05-27 | USE OF LOW MOLECULAR WEIGHT HEPARINES FOR THE PREPARATION OF MEDICINES FOR THE PREVENTION AND TREATMENT OF BRAIN EDEMAS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR013347A1 (en) |
-
1998
- 1998-05-27 AR ARP980102471 patent/AR013347A1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |