AR013342A1 - PSEUDOPEPTIDE COMPOUNDS, INTERMEDIATE COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULAS - Google Patents

PSEUDOPEPTIDE COMPOUNDS, INTERMEDIATE COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULAS

Info

Publication number
AR013342A1
AR013342A1 ARP980101644A ARP980101644A AR013342A1 AR 013342 A1 AR013342 A1 AR 013342A1 AR P980101644 A ARP980101644 A AR P980101644A AR P980101644 A ARP980101644 A AR P980101644A AR 013342 A1 AR013342 A1 AR 013342A1
Authority
AR
Argentina
Prior art keywords
group
taken
hydrogen
independently
atoms
Prior art date
Application number
ARP980101644A
Other languages
Spanish (es)
Original Assignee
Mena Campos Jesus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mena Campos Jesus filed Critical Mena Campos Jesus
Publication of AR013342A1 publication Critical patent/AR013342A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuestos con la formula general (I), donde R1 es (II), donde R5 se toma de un grupo formado por hidrogeno o metilo, X1 es -CONH-; X2 es -NR12CO-,donde R12 es hidrogeno o metilo; X3 se toma de un grupo formado por -NR12CO-, -NR12CONH-, donde R12coincide con el que se definio anteriormente; A es (III)donde B, C, D, y E, independientemente unos de otros, pueden ser CH o N; R6, R7, R8 y R9 son independientemente hidrogeno, OH o NR13R14, donde R13 y R14se toman independientemente dentro delgrupo formado por hidrogeno, metilo, ciclohexilo 4-piperidina; R2 se toma del grupo formado por (IV); R3 se tomadel grupo formado por radicales -aril, aril-alquil con un máximo de 15 átomos de carbono, mientras que el grupo -aril se toma del grupo formado porbenceno, nafteno, benzofurano e indol y posiblemente se sustituye en el anillo por uno o más átomos sustituyentes tomados independientemente en el grupoformado por halogeno, radical-alquil que contenga de 1 a 6 átomos de carbono, posiblemente sustituido por una cantidad de átomos fluor que no sea mayor a 3(por ejemplo, grupo trifluormetilo), radical oxialquil que contenga de 1 a 6 átomos de carbono, posiblemente sustituido por una cantidad de átomos fluorque no sea mayor a 3 (por ejemplo, grupo trifluormetoxilo), radical-tetrazole, -NH2, -NHR10, -N(R10)2, -OR10, -CONHR10, COR10, COOR10, R11COOR10, -OR11COOR10,-R11COR10, -CONHR10, -R11CONHR10, -NHCOR10 y radicales -nitro, donde R10 se toma del grupo formadopor radical-alquil o hidrogeno con cadenas linealeso ramificadas que contengan entre 1 y 6 átomos de carbono, y R11 es un radical alquilideno con cadena lineal o ramificada que contenga entre 1 y 6 átomos decarbono; teniendo en cuenta que: cuando una de las variables B, C, D, E es N, las otras son CH. Asimismo forman parte de la presente invencion las salesCompounds with the general formula (I), where R1 is (II), where R5 is taken from a group consisting of hydrogen or methyl, X1 is -CONH-; X2 is -NR12CO-, where R12 is hydrogen or methyl; X3 is taken from a group consisting of -NR12CO-, -NR12CONH-, where R12 matches the one defined above; A is (III) where B, C, D, and E, independently of each other, can be CH or N; R6, R7, R8 and R9 are independently hydrogen, OH or NR13R14, where R13 and R14 are independently taken within the group consisting of hydrogen, methyl, cyclohexyl 4-piperidine; R2 is taken from the group consisting of (IV); R3 is taken from the group consisting of -aryl, aryl-alkyl radicals with a maximum of 15 carbon atoms, while the -aryl group is taken from the group consisting of benzene, naphthene, benzofuran and indole and is possibly substituted in the ring by one or plus substituent atoms taken independently in the group consisting of halogen, alkyl radical containing from 1 to 6 carbon atoms, possibly substituted by a quantity of fluorine atoms not greater than 3 (for example, trifluoromethyl group), oxyalkyl radical containing 1 to 6 carbon atoms, possibly substituted by a quantity of fluorine atoms not exceeding 3 (for example, trifluormethoxy group), radical-tetrazole, -NH2, -NHR10, -N (R10) 2, -OR10, - CONHR10, COR10, COOR10, R11COOR10, -OR11COOR10, -R11COR10, -CONHR10, -R11CONHR10, -NHCOR10 and radicals -nitro, where R10 is taken from the group consisting of radical-alkyl or hydrogen with linear or branched chains containing between 1 and 6 atoms carbon, and R11 is a straight or branched chain alkylidene radical containing 1 to 6 carbon atoms; bearing in mind that: when one of the variables B, C, D, E is N, the others are CH. Also, salts are part of the present invention

ARP980101644A 1997-04-08 1998-04-08 PSEUDOPEPTIDE COMPOUNDS, INTERMEDIATE COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULAS AR013342A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97FI000072A IT1291823B1 (en) 1997-04-08 1997-04-08 PSEUDO-PEPTIDE COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS

Publications (1)

Publication Number Publication Date
AR013342A1 true AR013342A1 (en) 2000-12-27

Family

ID=11352030

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101644A AR013342A1 (en) 1997-04-08 1998-04-08 PSEUDOPEPTIDE COMPOUNDS, INTERMEDIATE COMPOUNDS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULAS

Country Status (5)

Country Link
AR (1) AR013342A1 (en)
AU (1) AU7522898A (en)
IT (1) IT1291823B1 (en)
WO (1) WO1998045262A1 (en)
ZA (1) ZA982952B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
JP4128138B2 (en) * 2001-06-20 2008-07-30 第一三共株式会社 Diamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
BR0211565A (en) * 2001-08-09 2004-06-29 Daiichi Seiyaku Co Diamine derivatives
MY130373A (en) 2001-10-29 2007-06-29 Malesci Sas Linear basic compounds having nk-2 antagonist activity and formulations thereof
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1256623B (en) * 1992-12-04 1995-12-12 Federico Arcamone TACHYCHININ ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS
JPH09504302A (en) * 1993-11-01 1997-04-28 日本チバガイギー株式会社 Endothelin receptor antagonist
IT1271462B (en) * 1993-12-03 1997-05-28 Menarini Farma Ind TACHYCHININ ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL FORMULATIONS.
ITFI940009A1 (en) * 1994-01-19 1995-07-19 Menarini Farma Ind ANTAGONISTS OF TACHYCININS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS THAT CONTAIN THEM.

Also Published As

Publication number Publication date
IT1291823B1 (en) 1999-01-21
ITFI970072A0 (en) 1997-04-08
AU7522898A (en) 1998-10-30
ITFI970072A1 (en) 1998-10-08
ZA982952B (en) 1998-10-12
WO1998045262A1 (en) 1998-10-15

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