AR012296A1 - A COMPOUND DERIVED FROM PHENOXIMETIL PIPERIDINE, ITS USE, A PROCEDURE FOR ITS PREPARATION AND A MEDICINAL PRODUCT CONTAINING ONE OR MORE COMPOUNDS DERIVED FROM PHENOXIMETIL PIPERIDINE - Google Patents
A COMPOUND DERIVED FROM PHENOXIMETIL PIPERIDINE, ITS USE, A PROCEDURE FOR ITS PREPARATION AND A MEDICINAL PRODUCT CONTAINING ONE OR MORE COMPOUNDS DERIVED FROM PHENOXIMETIL PIPERIDINEInfo
- Publication number
- AR012296A1 AR012296A1 ARP980101467A ARP980101467A AR012296A1 AR 012296 A1 AR012296 A1 AR 012296A1 AR P980101467 A ARP980101467 A AR P980101467A AR P980101467 A ARP980101467 A AR P980101467A AR 012296 A1 AR012296 A1 AR 012296A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- piperidine
- alkyl
- carbon atoms
- phenoximetil
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto derivado de la fenoximetil piperidina que responde a la formula (I), en donde: R1 es hidrogeno, alquilo de 1 a 4 átomos de carbono,-(CH2)m cicloalquilo, -(CH2)mNR7R8, o -(CH2)mNR7SO2R9; m es 1 a 3; R7 y R8 son, independientementeentre sí, hidrogeno o alquilo de 1 a 4 átomos de carbono; yR9 es alquilo de 1 a 4 átomos de carbono; R2, R3, R5 y R6 son independientemente entre sí, hidrogeno, alquilo de 1 a 4 átomos de carbono, ohalogeno; R4 es hidrogeno,alquilo de 1 a 4 átomos de carbono, hidroxilo, alquiloxilo, fluoroalquiloxilo, halogeno o fenilo o fenilo mono o disbustituidoseleccionándose los substituyentes del grupo formado por alquiloxilo, amino, nitro o acetilamino; con la condicionde que cuando R1 es hidrogeno, por lomenos dos de R2, R3, R4, R5 y R6 son distintos de hidrogeno; y además con la condicion de que cuando R1 es metilo y R2, R3, R5 y R6 son hidrogeno, R4 esdistinto de fluor; o una sal farmacéuticamente aceptableo un N-o xido de los mismos, coo isomero individual o como una mezcla de isomeros racémicos o noracémicos; su uso, un procedimiento para su preparacion y un medicamento que contiene uno o más compuestos derivados de la fenoximetil piperidina.Elcompuest o es un bloqueante de los canales de sodio, por lo que presenta propiedades farmacologicas de utilidad, incluyendo la aplicacion en eltratamiento de condiciones de dolor neuropático.A compound derived from phenoxymethyl piperidine that responds to formula (I), wherein: R1 is hydrogen, alkyl of 1 to 4 carbon atoms, - (CH2) m cycloalkyl, - (CH2) mNR7R8, or - (CH2) mNR7SO2R9; m is 1 to 3; R7 and R8 are, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms; and R9 is alkyl of 1 to 4 carbon atoms; R2, R3, R5 and R6 are independently from each other, hydrogen, alkyl of 1 to 4 carbon atoms, ohalogen; R4 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyl, alkyloxy, fluoroalkyloxy, halogen or phenyl or mono or disubstituted phenyl, the substituents being selected from the group consisting of alkyloxy, amino, nitro or acetylamino; with the proviso that when R1 is hydrogen, at least two of R2, R3, R4, R5 and R6 are different from hydrogen; and further with the proviso that when R1 is methyl and R2, R3, R5 and R6 are hydrogen, R4 is other than fluorine; or a pharmaceutically acceptable salt or N-oxide thereof, as an individual coo isomer or as a mixture of racemic or noracemic isomers; its use, a procedure for its preparation and a medicine that contains one or more compounds derived from phenoxymethyl piperidine. The compound is a blocker of sodium channels, therefore it has useful pharmacological properties, including the application in the treatment of conditions neuropathic pain.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4268197P | 1997-04-03 | 1997-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012296A1 true AR012296A1 (en) | 2000-10-18 |
Family
ID=21923206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980101467A AR012296A1 (en) | 1997-04-03 | 1998-04-04 | A COMPOUND DERIVED FROM PHENOXIMETIL PIPERIDINE, ITS USE, A PROCEDURE FOR ITS PREPARATION AND A MEDICINAL PRODUCT CONTAINING ONE OR MORE COMPOUNDS DERIVED FROM PHENOXIMETIL PIPERIDINE |
Country Status (10)
Country | Link |
---|---|
AR (1) | AR012296A1 (en) |
BR (1) | BR9801225A (en) |
CO (1) | CO4950566A1 (en) |
HR (1) | HRP980174A2 (en) |
ID (1) | ID20015A (en) |
PE (1) | PE64199A1 (en) |
TR (1) | TR199800596A2 (en) |
UY (1) | UY24947A1 (en) |
YU (1) | YU14498A (en) |
ZA (1) | ZA982618B (en) |
-
1998
- 1998-03-27 ZA ZA982618A patent/ZA982618B/en unknown
- 1998-03-27 PE PE00022998A patent/PE64199A1/en not_active Application Discontinuation
- 1998-04-01 YU YU14498A patent/YU14498A/en unknown
- 1998-04-01 TR TR1998/00596A patent/TR199800596A2/en unknown
- 1998-04-01 CO CO98018186A patent/CO4950566A1/en unknown
- 1998-04-02 UY UY24947A patent/UY24947A1/en not_active Application Discontinuation
- 1998-04-02 HR HRP980174 patent/HRP980174A2/en not_active Application Discontinuation
- 1998-04-03 BR BR9801225A patent/BR9801225A/en not_active IP Right Cessation
- 1998-04-03 ID IDP980506A patent/ID20015A/en unknown
- 1998-04-04 AR ARP980101467A patent/AR012296A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU14498A (en) | 1999-11-22 |
UY24947A1 (en) | 2001-01-31 |
TR199800596A3 (en) | 1998-10-21 |
HRP980174A2 (en) | 1999-04-30 |
TR199800596A2 (en) | 1998-10-21 |
CO4950566A1 (en) | 2000-09-01 |
ZA982618B (en) | 1998-10-05 |
ID20015A (en) | 1998-09-10 |
BR9801225A (en) | 1999-06-01 |
PE64199A1 (en) | 1999-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL315636A1 (en) | Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives | |
SE9702799D0 (en) | New compounds | |
HUP0004076A2 (en) | C-4"-substituted macrolide derivatives | |
MX9305379A (en) | NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATION CONTAINING THEM. | |
GEP20033116B (en) | New Esters Derived From Substituted Phenyl-Cyclohexyl Compounds, Methods for Their Production for Preparation Drug with Analgesic Properties | |
AR033306A1 (en) | COMPOUNDS | |
MY105328A (en) | Blocking agents of edrf effect or formation for the treatment of shock. | |
DE69637097D1 (en) | 8-AZABICYCLO (3.2.1) OCT-2EN DERIVATIVES, THEIR PREPARATION AND APPLICATION | |
IL111127A (en) | Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them | |
AR006360A1 (en) | DERIVATIVES OF 1,2,3,4-TETRAHIDRONAFTALENO SUBSTITUTED, USE OF THE SAME FOR THE PREPARATION OF MEDICINES AND PROCEDURE FOR THE PREPARATION. | |
EP0765865A4 (en) | 2-acylaminopropanol compound and medicinal composition | |
SE9703377D0 (en) | New compounds | |
NZ194528A (en) | 4-phenoxypiperidines preparation and pharmaceutical compositions containing them | |
EA199801028A1 (en) | APPLICATION OF DERIVATIVES OF P-AMINOPHENOL FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS USED IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | |
GB1086192A (en) | Phenylcyclopropane derivatives | |
BG103426A (en) | Derivatives of substituted 4-biphenyl-4-hydroxy-oil acids as inhibitors of matrix metalloproteases | |
FI964482A0 (en) | Amide derivatives and their use as drugs | |
IL112432A0 (en) | Fatty acid derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same | |
JO1622B1 (en) | Indenoindole compounds II | |
AR009374A1 (en) | NOVEL NMDA ANTAGONIST COMPOUNDS (N-METHYL-D-ASPARTATE), PHARMACEUTICAL COMPOSITION AND USES FOR MANUFACTURE OF MEDICINES. | |
AR012296A1 (en) | A COMPOUND DERIVED FROM PHENOXIMETIL PIPERIDINE, ITS USE, A PROCEDURE FOR ITS PREPARATION AND A MEDICINAL PRODUCT CONTAINING ONE OR MORE COMPOUNDS DERIVED FROM PHENOXIMETIL PIPERIDINE | |
DK0707570T3 (en) | Isoquinoline derivatives as therapeutic agents | |
AR018675A1 (en) | DERIVATIVES OF 3- (2-OXO- [1,3¿I¿] BIPIRROLIDINIL-3-ILIDENOMETIL) -CEFEM, A PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. | |
IL153784A0 (en) | Novel n-(2-phenyl-3-aminopropyl) naphthamides | |
AR037458A1 (en) | A COMPOSITE DERIVED FROM PIPERIDINE, ITS EMPLOYMENT, METHODS TO PREPARE IT AND A COMPOSITION CONTAINING IT |