AR012096A1 - N- (ARGINYL) BENZENOSULFONAMIDE-DERIVED COMPOUNDS, MEDICINES AND PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEM AND PROCEDURES FOR PREPAREDICED DERIVATIVE COMPOUNDS. - Google Patents

N- (ARGINYL) BENZENOSULFONAMIDE-DERIVED COMPOUNDS, MEDICINES AND PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEM AND PROCEDURES FOR PREPAREDICED DERIVATIVE COMPOUNDS.

Info

Publication number
AR012096A1
AR012096A1 ARP980101211A ARP980101211A AR012096A1 AR 012096 A1 AR012096 A1 AR 012096A1 AR P980101211 A ARP980101211 A AR P980101211A AR P980101211 A ARP980101211 A AR P980101211A AR 012096 A1 AR012096 A1 AR 012096A1
Authority
AR
Argentina
Prior art keywords
alkyl
compounds
arginyl
procedures
pharmaceutical compositions
Prior art date
Application number
ARP980101211A
Other languages
Spanish (es)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR012096A1 publication Critical patent/AR012096A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de N-(arginil)bencenosulfamida de formula (I), donde R, R1 y R1representan cada uno hidrogeno, (C1-C4)alquilo, (C1-C4)alcoxicarbonilo,(C2-C4)alqueniloxicarbonilo, fenil(C1-C4)alcoxicarbonilo, (C1-C4)alcanoílo, fenil(C1-C4)alquilo(C1-C4)alcanoílo, R2 representapiperidin-1-ilo, espiro[(C3-C6)cicloalcano-1,4-piperidin]-1-ilo, 1,2,3,6-tetrahidropiridin-1-ilo, hexahidro-1H-acepin-1-ilo,heptahidroazocin-1-ilo, octahidro-1H-azocin-1-ilo (II); (siendo A-B-CONR,R= H o (C1-C4)alquilo, (Q = C o N, siendo D(C1-C4)alquilo o -CH2CF3, r= 1 a3), R3 representa hidrogeno, (C1-C5)alquilo recto o ramificado, -COR5[R5(C1-C4) alquilo, -(CH2)nOCH3, CH2O(C2H4O)nCH3, -(CH2)nCF3, (CH2)nOH(n = 1 a 4]), SO2R6,CONHR6, SO2N(R6)2[R6 = (C1-C4)alquilo], R4 representa H o halogeno, A representa halogeno, fenilo, heterociclo, ciclo (C5-C8)alquilo. Medicamentos ycomposiciones farmacéuticas que los comprende y procedimientos para preparar estos compuestos. Los compuestos pueden ser utiles en todas las indicacionesclínicas relacionadas con la trombosis o en aquellas en las que podrían intervenir complicaciones tromboticas.Compounds derived from N- (arginyl) benzenesulfamide of formula (I), where R, R1 and R1 each represent hydrogen, (C1-C4) alkyl, (C1-C4) alkoxycarbonyl, (C2-C4) alkenyloxycarbonyl, phenyl (C1- C4) alkoxycarbonyl, (C1-C4) alkanoyl, phenyl (C1-C4) (C1-C4) alkyl alkanoyl, R2 represents piperidin-1-yl, spiro [(C3-C6) cycloalkane-1,4-piperidin] -1- yl, 1,2,3,6-tetrahydropyridin-1-yl, hexahydro-1H-accepin-1-yl, heptahydroazocin-1-yl, octahydro-1H-azocin-1-yl (II); (where AB-CONR, R = H or (C1-C4) alkyl, (Q = C or N, where D (C1-C4) is alkyl or -CH2CF3, r = 1 to 3), R3 represents hydrogen, (C1-C5 ) straight or branched alkyl, -COR5 [R5 (C1-C4) alkyl, - (CH2) nOCH3, CH2O (C2H4O) nCH3, - (CH2) nCF3, (CH2) nOH (n = 1 to 4]), SO2R6, CONHR6, SO2N (R6) 2 [R6 = (C1-C4) alkyl], R4 represents H or halogen, A represents halogen, phenyl, heterocycle, cyclo (C5-C8) alkyl.Compounds and pharmaceutical compositions comprising them and procedures for preparing These compounds The compounds can be useful in all clinical indications related to thrombosis or in those in which thrombotic complications could intervene.

ARP980101211A 1997-03-20 1998-03-18 N- (ARGINYL) BENZENOSULFONAMIDE-DERIVED COMPOUNDS, MEDICINES AND PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEM AND PROCEDURES FOR PREPAREDICED DERIVATIVE COMPOUNDS. AR012096A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703392A FR2761065B1 (en) 1997-03-20 1997-03-20 N- (ARGINYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR012096A1 true AR012096A1 (en) 2000-09-27

Family

ID=9505004

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101211A AR012096A1 (en) 1997-03-20 1998-03-18 N- (ARGINYL) BENZENOSULFONAMIDE-DERIVED COMPOUNDS, MEDICINES AND PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEM AND PROCEDURES FOR PREPAREDICED DERIVATIVE COMPOUNDS.

Country Status (6)

Country Link
EP (1) EP0971916A1 (en)
AR (1) AR012096A1 (en)
AU (1) AU6924398A (en)
FR (1) FR2761065B1 (en)
WO (1) WO1998042700A1 (en)
ZA (1) ZA982355B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2793418B1 (en) * 1999-05-11 2001-07-27 Synthelabo GALENIC FORMULATIONS OF ANTITHROMBOTIC AGENTS FOR SUBCUTANEOUS ADMINISTRATION
CN105707076B (en) * 2014-12-05 2018-12-14 沈阳中化农药化工研发有限公司 Herbicidal combinations and application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1131621A (en) * 1977-01-19 1982-09-14 Shosuke Okamoto N.sup.2-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
GB9505538D0 (en) * 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds
FR2735469B1 (en) * 1995-06-13 1997-07-11 Synthelabo N2- (ARYLSULFONYL) -L-ARGINYLPIPERIDIN-2-CARBOXYLATES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
WO1998042700A1 (en) 1998-10-01
ZA982355B (en) 1998-09-22
EP0971916A1 (en) 2000-01-19
FR2761065B1 (en) 2000-03-03
AU6924398A (en) 1998-10-20
FR2761065A1 (en) 1998-09-25

Similar Documents

Publication Publication Date Title
ES2011296B3 (en) DERIVATIVES OF BENZO [B] THIOFEN AND BENZO [B] FURANO CARBOXAMIDES, THEIR PREPARATION PROCEDURES AND THE DRUGS CONTAINING THEM.
YU16899A (en) Aralkyl and aralkylidene heterocyclic lactams and imides
DK0483772T3 (en) Aminocumaran derivatives, and their preparation and use
DK554288D0 (en) HETEROCYCLIC SPIRO COMPOUNDS AND PROCEDURES FOR PREPARING THEREOF
FR2619111B1 (en) (PIPERIDINYL-4) METHYL-2 TETRAHYDRO-1,2,3,4 9H-PYRIDO (3,4-B) INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CO4520230A1 (en) DERIVATIVES OF [3- (4-PHENYLPIPERACIN-1-IL) PROPYLAMINE, UNCLE AND OXYL] -PIRIDINE, PYRIMIDINE AND BENZENE AS ALPHA ANTAGONISTS 1- ADRENOCEPTORS
DE3675087D1 (en) PYRIDONE CARBONIC DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
MY101970A (en) Zwitterionic bicyclic compounds and their salts, solvates, hydrates and esters.
ZA868630B (en) New 3-oxadiazole and 3-carboxylic acid beta-carboline derivatives,their production and their use as drugs
DE69008142T2 (en) 4-substituted imidazoles for lowering intraocular pressure.
AR033996A1 (en) A 7-OXO-PYRIDOPIRIMIDINE, ITS USE, A PROCESS TO PREPARE IT, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A PROCESS TO PRODUCE A PYRIMIDINE, A PROCESS TO PRODUCE A PYRIDOPIRIMIDINE, AND PREPARED COMPOUNDS THROUGH
DE3776385D1 (en) METHOD FOR PRODUCING D - (+) - BIOTIN.
IL76175A (en) N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them
AR040140A1 (en) CAMPTOTECHINE ESTERS DERIVATIVES IN POSITION 20
AR044275A1 (en) USE OF SULFONAMID DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR PROFILAXIS AND / OR TREATMENT OF FOOD DYSFUNCTIONS
AR012096A1 (en) N- (ARGINYL) BENZENOSULFONAMIDE-DERIVED COMPOUNDS, MEDICINES AND PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THEM AND PROCEDURES FOR PREPAREDICED DERIVATIVE COMPOUNDS.
PT91555A (en) METHOD FOR PREPARING DIBENZO (2,3,6,7) - (OXEPINO OR TIEPINO) {4,5-C} (PYRIDINE OR PYRROLE) DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK178388A (en) TRICYCLIC AMINES DERIVATED BY 2,3,5,6,7,8-HEXAHYDRONAPHTHO- (2,3-B) FURAN AND 2,3,6,7,8,9-HEXAHYDRO-5H-BENZOCYCLOHEPTA- (2,3) -B) FURAN, PROCEDURES FOR THEIR MANUFACTURING AND PHARMACEUTICAL AGENTS CONTAINING THEM
ES2055717T3 (en) DERIVATIVES OF BENZO- AND TIENO-3,4-DIHIDRO-PIRIDINA, PROCEDURES FOR ITS PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS.
HUP0103020A2 (en) Heterocyclic derivatives as fkbp inhibitors, process for their preparation, their intermediates and pharmaceutical compositions containing them
ATE76408T1 (en) CARBAPENEM ANTIBIOTICS, A PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE3667789D1 (en) PIPERAZINE-1-YL ERGOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
DK471686A (en) TETRAHYDRO-BETA CARBOLINES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINE
DK290386A (en) IMIDAZOLIDE CONNECTION AND PROCEDURES FOR PRODUCING THEREOF
NO932525D0 (en) 1N-SUBSTITUTED PYRAZINE- (2,3-C) -1,2,6-THIADIAZINE-2,2-DIOXIDES AND PROCEDURES FOR THEIR PREPARATION