AR012095A1 - DIHYDROPIRAZINE [1,2-a] INDOL-1-ONA DERIVED COMPOUNDS, PROCEDURES FOR PREPARING SUCH DERIVATIVE COMPOUNDS AND MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM. - Google Patents

DIHYDROPIRAZINE [1,2-a] INDOL-1-ONA DERIVED COMPOUNDS, PROCEDURES FOR PREPARING SUCH DERIVATIVE COMPOUNDS AND MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM.

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Publication number
AR012095A1
AR012095A1 ARP980101210A ARP980101210A AR012095A1 AR 012095 A1 AR012095 A1 AR 012095A1 AR P980101210 A ARP980101210 A AR P980101210A AR P980101210 A ARP980101210 A AR P980101210A AR 012095 A1 AR012095 A1 AR 012095A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
hydroxy
hydrogen
nhcor4
Prior art date
Application number
ARP980101210A
Other languages
Spanish (es)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR012095A1 publication Critical patent/AR012095A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Compuestos derivados de dihidropirazino[1,2-a]indol-1-ona que responden a la formula I en donde: R1 y R2 representan cada uno independientemente uno deotro, hidrogeno, halogeno, o un grupo amino, hidroxi, nitro, ciano, (C1-C6)alquilo, (C1-C6)alcoxi, trifluorometilo, trifluorometoxi, -COOH, -COOR4,-CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, NHSO2R4, o un grupo -N(R4)2 (en donde R4 y R5 son cada uno (C1-C4)alquilo), R3 representa hidrogeno, o ungrupo (C1-C6)alquilo, -(CH2)pOH, -(CH2)nCH(OH)(CH2)nOH, -(CH2)pNH2, (CH2)pNHR7 (en donde R7 es -C(=NH)-NH2), -(CH2)nCOOH, -(CH2)nCOOR, -(CH2)nCN, -(CH2)n--tetrazol-5-ilo, -(CH2)nCONH2, o un grupo de formula II (en donde G es -CH2-, -CH(OH)- o -NH-), o un grupo -(CH2)nCONHR8 (endonde R8 es un grupo hidroxi,(C1-C4)alcoxi o 1-metilpiperidin-4-ilo), o un grupo -(CH2)nCONH(CH2)nR9 (en donde R9 es un grupo hidroxi o -NR4R5), (CH2)nCONAA (en donde AA es un residuode ácido aminado), -(CH2)pSH, -(CH2)nSO3H, -(CH2)nS2NH2, -(CH2)nSO2NHR4, -(CH2)nSO2NR4R5, -(CH2)nCONHR4, -(CH2)nCONR4R5, -(CH2)pNHSO2R4, -(CH2)pNHCOR4,o un grupo -(CH2)pOCOR4, en donde R4 Y R5 son cadauno un grupo (C1-C4)alquilo, n es igual a 1 a 4 y p es igual 2, 3 o 4, Q representa dos átomos de hidrogenoo un átomo de oxígeno, Z representa un nitrogeno o un -CH-, A representa un grupo (1) o un grupo (2): siendo elegido B entre oxígeno y azufre y los grupos-NH- y -N(R4)- y siendo R6 independientemente de R1 y R2 un hidrogeno, halogeno , amino,hidroxi, nitro, ciano, (C1-C6)alquilo, (C1-C6)alcoxi, trifluorometilo,trifluorometoxi, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, -NHCOR4, -NHSO2R4, o un grupo -n(R4)2 en donde R4 y R5 son cada uno ungrupo (C1-C4)alquilo, bajo la forma de racematos, enantiomeros puros o mezclas de enantiomeros, así como sus sales de adicion a los ácidos o a las basesCompounds derived from dihydropyrazino [1,2-a] indole-1-one responding to formula I wherein: R1 and R2 each independently represent one another, hydrogen, halogen, or an amino, hydroxy, nitro, cyano group, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, NHSO2R4, or a -N group ( R4) 2 (where R4 and R5 are each (C1-C4) alkyl), R3 represents hydrogen, or a group (C1-C6) alkyl, - (CH2) pOH, - (CH2) nCH (OH) (CH2) nOH, - (CH2) pNH2, (CH2) pNHR7 (where R7 is -C (= NH) -NH2), - (CH2) nCOOH, - (CH2) nCOOR, - (CH2) nCN, - (CH2) n --tetrazol-5-yl, - (CH2) nCONH2, or a group of formula II (where G is -CH2-, -CH (OH) - or -NH-), or a group - (CH2) nCONHR8 ( where R8 is a hydroxy group, (C1-C4) alkoxy or 1-methylpiperidin-4-yl), or a group - (CH2) nCONH (CH2) nR9 (where R9 is a hydroxy group or -NR4R5), (CH2 ) nCONAA (where AA is an amino acid residue), - (CH2) pSH, - (CH2) nSO3H, - (CH2) nS2NH2, - (CH2) nSO2NHR4, - (CH2) nSO2NR 4R5, - (CH2) nCONHR4, - (CH2) nCONR4R5, - (CH2) pNHSO2R4, - (CH2) pNHCOR4, or a group - (CH2) pOCOR4, where R4 and R5 are each a (C1-C4) alkyl group , n is equal to 1 to 4 and p is equal to 2, 3 or 4, Q represents two hydrogen atoms or one oxygen atom, Z represents a nitrogen or a -CH-, A represents a group (1) or a group (2 ): B being chosen from oxygen and sulfur and the groups -NH- and -N (R4) - and R6 being independently of R1 and R2 a hydrogen, halogen, amino, hydroxy, nitro, cyano, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, -NHCOR4, -NHSO2R4, or a -n (R4) 2 group wherein R4 and R5 are each a (C1-C4) alkyl group, in the form of racemates, pure enantiomers or mixtures of enantiomers, as well as their acid or base addition salts

ARP980101210A 1997-03-20 1998-03-18 DIHYDROPIRAZINE [1,2-a] INDOL-1-ONA DERIVED COMPOUNDS, PROCEDURES FOR PREPARING SUCH DERIVATIVE COMPOUNDS AND MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM. AR012095A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703389A FR2761070B1 (en) 1997-03-20 1997-03-20 DIHYDROPYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR012095A1 true AR012095A1 (en) 2000-09-27

Family

ID=9505000

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101210A AR012095A1 (en) 1997-03-20 1998-03-18 DIHYDROPIRAZINE [1,2-a] INDOL-1-ONA DERIVED COMPOUNDS, PROCEDURES FOR PREPARING SUCH DERIVATIVE COMPOUNDS AND MEDICINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM.

Country Status (6)

Country Link
EP (1) EP0971926A1 (en)
AR (1) AR012095A1 (en)
AU (1) AU6924098A (en)
FR (1) FR2761070B1 (en)
WO (1) WO1998042710A1 (en)
ZA (1) ZA982369B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2248281T3 (en) 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. USEFUL PHENOXIALQUILAMINE DERIVATIVES AS AGONISTS OF DELTA OPIOID RECEIVER.
KR102069913B1 (en) 2012-03-16 2020-01-23 비타이 파마슈티컬즈, 엘엘씨 Liver x receptor modulators
ES2598653T3 (en) 2012-03-16 2017-01-30 Vitae Pharmaceuticals, Inc. Liver X receptor modulators
EP3122353B1 (en) * 2014-03-27 2020-10-28 Vanderbilt University Substituted indole mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
CA3016182C (en) 2016-03-04 2024-02-27 Vanderbilt Universtiy Substituted indole mcl-1 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2027898A6 (en) * 1991-01-24 1992-06-16 Espanola Prod Quimicos 2-Methoxyphenylpiperazine derivatives.
EP0572863A1 (en) * 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag CNS pyrazinoindoles

Also Published As

Publication number Publication date
WO1998042710A1 (en) 1998-10-01
FR2761070A1 (en) 1998-09-25
EP0971926A1 (en) 2000-01-19
AU6924098A (en) 1998-10-20
FR2761070B1 (en) 1999-04-23
ZA982369B (en) 1998-09-23

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