AR011799A1 - BENZAMIDES THAT HAVE AFFINITY FOR THE D4 RECEPTOR OF DOPAMINE, PHARMACEUTICAL COMPOSITION, USE FOR THE MANUFACTURE OF MEDICINES AND PROCEDURE OF OBTAINMENT - Google Patents
BENZAMIDES THAT HAVE AFFINITY FOR THE D4 RECEPTOR OF DOPAMINE, PHARMACEUTICAL COMPOSITION, USE FOR THE MANUFACTURE OF MEDICINES AND PROCEDURE OF OBTAINMENTInfo
- Publication number
- AR011799A1 AR011799A1 ARP980100647A AR011799A1 AR 011799 A1 AR011799 A1 AR 011799A1 AR P980100647 A ARP980100647 A AR P980100647A AR 011799 A1 AR011799 A1 AR 011799A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- benzamides
- membered aromatic
- heteroaromatic ring
- receptor
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Benzamidas de formula (I), donde R1 es un anillo aromático o heteroaromático de 5 o 6 miembros, unido en la posicion meta o para del grupofenilo de la benzamida, donde dicho anillo está eventualmente substituido con 1 o 2 gruposindepe ndientemente seleccionados entre alquilo inferior, alcoxiinferior, hidroxi, halo, ciano, alquilo inferior-S-, alquilo inferior-SO-, alquilo inferior-SO2-, (alquilo inferior)2NSO2, H(O)C-, HO2C-, trifluorometilo,trifluorometoxi, H2N,alquilo infe rior-NH-, (alquilo inferior)2N- y alquilo inferior-carbonilo; R2 es seleccionado entre un anillo aromático oheteroaromático de 5 o 6 miembros eventualmente substituido y un anillo aromático o heteroaromático de 6 miembroseventualmente su bstituido fusionadoa un hetero- o carbociclo de 5 o 6 miembros; n es 1 o 2; y las sales, solvatos, estereoisomeros o hidratos de los mismos, con la condicion de que R1 no seaimidazol cuando n es 2 y R2 es fenilo. Las referidasbenzamidas se incluyen en composiciones farmacéuticas y son utiles para el tratamiento de unacondicion médica para la que está indicado un antagonistas de los receptores D4 en particular esquizofrenia.Benzamides of formula (I), where R1 is a 5- or 6-membered aromatic or heteroaromatic ring, attached at the meta or para position of the benzamide group, where said ring is optionally substituted with 1 or 2 groups independently selected from lower alkyl , lower alkoxy, hydroxy, halo, cyano, lower alkyl-S-, lower alkyl-SO-, lower alkyl-SO2-, (lower alkyl) 2NSO2, H (O) C-, HO2C-, trifluoromethyl, trifluoromethoxy, H2N, alkyl lower-NH-, (lower alkyl) 2N- and lower alkyl-carbonyl; R2 is selected from an optionally substituted 5- or 6-membered aromatic or heteroaromatic ring and a 6-membered aromatic or heteroaromatic ring eventually substituted by fused to a 5- or 6-membered hetero- or carbocycle; n is 1 or 2; and the salts, solvates, stereoisomers or hydrates thereof, with the proviso that R1 is notimidazole when n is 2 and R2 is phenyl. These benzamides are included in pharmaceutical compositions and are useful for the treatment of a medical condition for which a D4 receptor antagonist, in particular schizophrenia, is indicated.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80262197A | 1997-02-19 | 1997-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011799A1 true AR011799A1 (en) | 2000-09-13 |
Family
ID=25184244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100647 AR011799A1 (en) | 1997-02-19 | 1998-02-13 | BENZAMIDES THAT HAVE AFFINITY FOR THE D4 RECEPTOR OF DOPAMINE, PHARMACEUTICAL COMPOSITION, USE FOR THE MANUFACTURE OF MEDICINES AND PROCEDURE OF OBTAINMENT |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR011799A1 (en) |
| ZA (1) | ZA981221B (en) |
-
1998
- 1998-02-13 AR ARP980100647 patent/AR011799A1/en unknown
- 1998-02-13 ZA ZA981221A patent/ZA981221B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA981221B (en) | 1998-08-27 |
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