AR011136A1 - DERIVATIVE COMPOUND 4-AMINOALCOXI-1H-BENZOIMIDAZOLES, PHARMACEUTICAL COMPOSITION CONTAINING IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents

DERIVATIVE COMPOUND 4-AMINOALCOXI-1H-BENZOIMIDAZOLES, PHARMACEUTICAL COMPOSITION CONTAINING IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT

Info

Publication number
AR011136A1
AR011136A1 ARP980100617A ARP980100617A AR011136A1 AR 011136 A1 AR011136 A1 AR 011136A1 AR P980100617 A ARP980100617 A AR P980100617A AR P980100617 A ARP980100617 A AR P980100617A AR 011136 A1 AR011136 A1 AR 011136A1
Authority
AR
Argentina
Prior art keywords
hydrogen
alkyl
benzoimidazoles
manufacture
pharmaceutical composition
Prior art date
Application number
ARP980100617A
Other languages
Spanish (es)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR011136A1 publication Critical patent/AR011136A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos derivados de 4-aminoalcoxi-1H-benzoimidazoles D2 dopaminérgicos de la formula (I), en la cual: R1 es hidrogeno, trifluorometilo,pentafluoroetilo, heptafluoropropilo, un grupo alquilo de cadena recta o ramificada conhasta 6 carbonos o bencilo optativamente sustituido por uno atres sustituyentes seleccionados entre halogeno, amino, nitro, hidroxi, y alcoxi C1-C6; R2 es hidrogeno o alquilo C1-C6; R3 es hidrogeno, alquilo C1-C10de cadena recta o ramificada con hasta 10 átomos de carbono, ciclohexilmetilo, -(CH2)mAr, donde Ar es fenilo, naftalenilo, tienilo, furanilo o piridinilo,cada uno de ellos optativamente sustituido por uno o dos sustituyentes seleccionados entre alcoxi C1-C6, trifluorometilo y alquilo C1-C6; p NR2R3 es1,2,3,4-tetrahidroquinolin-1-ilo o 1,2,3,4-tetrahidroisoquinolin-1-ilo; Y = hidrogeno, halogeno, alquilo inferior, amino, o alcoxi inferior; m = 1 o 3;n = 1 - 5; o una sal farmacéuticamente aceptable del mismo. Estos compuestos D2 dopaminérgicos son utiles en el tratamiento de la esquizofrenia, laenfermedad de Parkinson, el síndrome de Tourette, y la adicion a las drogas o al alcohol. También se define una composicion farmacéutica que los contienen yel uso de dichos compuestos para la fabricacion de un medicamento.Compounds derived from 4-aminoalkoxy-1H-benzoimidazoles D2 dopaminergic of formula (I), in which: R1 is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, an alkyl group with up to 6 carbons or benzyl optionally substituted by one three substituents selected from halogen, amino, nitro, hydroxy, and C1-C6 alkoxy; R2 is hydrogen or C1-C6 alkyl; R3 is hydrogen, C1-C10 straight chain or branched alkyl with up to 10 carbon atoms, cyclohexylmethyl, - (CH2) mAr, where Ar is phenyl, naphthalenyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected from C1-C6 alkoxy, trifluoromethyl and C1-C6 alkyl; p NR2R3 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-1-yl; Y = hydrogen, halogen, lower alkyl, amino, or lower alkoxy; m = 1 or 3, n = 1-5; or a pharmaceutically acceptable salt thereof. These dopamine D2 compounds are useful in the treatment of schizophrenia, Parkinson's disease, Tourette syndrome, and drug or alcohol addiction. A pharmaceutical composition containing them is also defined and the use of said compounds for the manufacture of a medicine.

ARP980100617A 1997-02-18 1998-02-11 DERIVATIVE COMPOUND 4-AMINOALCOXI-1H-BENZOIMIDAZOLES, PHARMACEUTICAL COMPOSITION CONTAINING IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AR011136A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80127697A 1997-02-18 1997-02-18

Publications (1)

Publication Number Publication Date
AR011136A1 true AR011136A1 (en) 2000-08-02

Family

ID=25180658

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980100617A AR011136A1 (en) 1997-02-18 1998-02-11 DERIVATIVE COMPOUND 4-AMINOALCOXI-1H-BENZOIMIDAZOLES, PHARMACEUTICAL COMPOSITION CONTAINING IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT

Country Status (14)

Country Link
EP (1) EP0973749A1 (en)
JP (1) JP2001509814A (en)
KR (1) KR20000071129A (en)
CN (1) CN1252793A (en)
AR (1) AR011136A1 (en)
AU (1) AU746717B2 (en)
BR (1) BR9807701A (en)
CA (1) CA2278700A1 (en)
HU (1) HUP0001302A3 (en)
IL (1) IL131158A0 (en)
NZ (1) NZ336969A (en)
TW (1) TW513415B (en)
WO (1) WO1998035945A1 (en)
ZA (1) ZA981309B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
CN101597262A (en) * 2002-03-05 2009-12-09 特兰斯泰克制药公司 The list and the bicyclic pyrrole derivatives that suppress part and advanced glycation end product acceptor interaction
TWI517850B (en) 2009-09-30 2016-01-21 Ｖｔｖ治療有限責任公司 Substituted imidazole derivatives and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
ES2169102T3 (en) * 1994-10-14 2002-07-01 Merck Patent Gmbh (R) - (-) - 2- (5- (4-FLUORFENIL) -3-PIRIDILMETILAMINOMETIL) -CROMANO AS ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM.
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
DE69719765T2 (en) * 1996-08-27 2003-10-16 Wyeth Corp 4-AMINOETHOXY INDOLDER DERIVATIVES AS DOPAMINE D2 AGONISTS AND AS 5HT1A LIGANDS

Also Published As

Publication number Publication date
AU746717B2 (en) 2002-05-02
JP2001509814A (en) 2001-07-24
HUP0001302A3 (en) 2001-07-30
NZ336969A (en) 2001-03-30
ZA981309B (en) 1999-08-17
CN1252793A (en) 2000-05-10
TW513415B (en) 2002-12-11
CA2278700A1 (en) 1998-08-20
IL131158A0 (en) 2001-01-28
KR20000071129A (en) 2000-11-25
WO1998035945A1 (en) 1998-08-20
BR9807701A (en) 2000-05-02
HUP0001302A2 (en) 2001-05-28
EP0973749A1 (en) 2000-01-26
AU5915398A (en) 1998-09-08

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